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288150-92-5,MFCD06411575
Catalog No.:AA002WIY

288150-92-5 | SB-408124

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$18.00   $13.00
- +
5mg
98%
in stock  
$56.00   $39.00
- +
100mg
98
in stock  
$1,022.00   $715.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002WIY
Chemical Name:
SB-408124
CAS Number:
288150-92-5
Molecular Formula:
C19H18F2N4O
Molecular Weight:
356.3692
MDL Number:
MFCD06411575
SMILES:
O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C
Properties
Properties
 
BP:
430.3±45.0 °C(Predicted)  
Form:
Solid  
Solubility:
DMSO: ~24 mg/mL  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
484  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.5  

Literature

Title: Selective orexin receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20130901

Title: Neuroendocrine regulatory peptide-1 and neuroendocrine regulatory peptide-2 influence differentially feeding and penile erection in male rats: sites of action in the brain.

Journal: Regulatory peptides 20120820

Title: The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats.

Journal: Pflugers Archiv : European journal of physiology 20120401

Title: Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.

Journal: PloS one 20120101

Title: Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

Journal: British journal of pharmacology 20110301

Title: Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes.

Journal: Pharmacological reports : PR 20110101

Title: [Cardiovascular effect of intracerebroventricular injection of orexin-1 receptor antagonist in rats].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100801

Title: Modulation of respiratory activity by hypocretin-1 (orexin A) in situ and in vitro.

Journal: Advances in experimental medicine and biology 20100101

Title: Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network.

Journal: Biological psychiatry 20090515

Title: Langmead CJ, et al. Characterisation of the binding of H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141(2):340-346.

Title: Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463(4):531-536.

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