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Title: A Redox-Sensitive and RAGE-Targeting Nanocarrier for Hepatocellular Carcinoma Therapy.
Journal: Molecular pharmaceutics 20161107
Title: Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression.
Journal: Chemico-biological interactions 20150505
Title: Interaction of oridonin with human serum albumin by isothermal titration calorimetry and spectroscopic techniques.
Journal: Chemico-biological interactions 20150505
Title: The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress.
Journal: Free radical research 20121101
Title: Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway.
Journal: Free radical research 20121001
Title: Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway.
Journal: International journal of oncology 20120901
Title: Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway.
Journal: Acta pharmacologica Sinica 20120801
Title: Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents.
Journal: Molecules (Basel, Switzerland) 20120618
Title: The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents.
Journal: European journal of medicinal chemistry 20120601
Title: [Longikaurin A induces apoptosis of multiple myeloma H929 cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20120601
Title: [Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501
Title: Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Journal: International journal of molecular medicine 20120401
Title: In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers.
Journal: International journal of biological macromolecules 20120401
Title: Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein.
Journal: Science translational medicine 20120328
Title: Study on the autophagy of prostate cancer PC-3 cells induced by oridonin.
Journal: Anatomical record (Hoboken, N.J. : 2007) 20120301
Title: Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells.
Journal: Archives of biochemistry and biophysics 20120201
Title: Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro.
Journal: Journal of biomedical nanotechnology 20120201
Title: Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells.
Journal: International journal of oncology 20120101
Title: Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1.
Journal: Acta pharmacologica Sinica 20120101
Title: RGD-modified poly(D,L-lactic acid) nanoparticles enhance tumor targeting of oridonin.
Journal: International journal of nanomedicine 20120101
Title: Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line.
Journal: International journal of nanomedicine 20120101
Title: Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens.
Journal: Phytochemical analysis : PCA 20120101
Title: Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells.
Journal: International journal of biological sciences 20120101
Title: Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin.
Journal: Biomacromolecules 20111212
Title: [Study on pharmacokinetics of oridonin in mice].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201
Title: Oridonin nanosuspension enhances anti-tumor efficacy in SMMC-7721 cells and H22 tumor bearing mice.
Journal: Colloids and surfaces. B, Biointerfaces 20111015
Title: Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells.
Journal: Acta pharmacologica Sinica 20111001
Title: Isolation and purification of oridonin from the whole plant of Isodon rubescens by high-speed counter-current chromatography.
Journal: Molecules (Basel, Switzerland) 20110914
Title: Sensitization to TRAIL-induced apoptosis in human neuroblastoma SK-N-AS cells by NF-κB inhibitors is dependent on reactive oxygen species (ROS).
Journal: Journal of neuro-oncology 20110901
Title: Oridonin induced the apoptosis of PC-3 cells and its mechanism.
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110801
Title: Stimulation of suicidal erythrocyte death by oridonin.
Journal: Archives of biochemistry and biophysics 20110701
Title: Synthesis and revision of stereochemistry of rubescensin S.
Journal: Organic & biomolecular chemistry 20110621
Title: Development and in-vivo assessment of the bioavailability of oridonin solid dispersions by the gas anti-solvent technique.
Journal: International journal of pharmaceutics 20110615
Title: Proteomic and functional analyses reveal the potential involvement of endoplasmic reticulum stress and α-CP1 in the anticancer activities of oridonin in HepG2 cells.
Journal: Integrative cancer therapies 20110601
Title: Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting.
Journal: International journal of pharmaceutics 20110516
Title: Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension.
Journal: Drug delivery 20110501
Title: Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics.
Journal: The international journal of biochemistry & cell biology 20110501
Title: Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals.
Journal: Cell biology and toxicology 20110401
Title: Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: studies in vitro and in vivo.
Journal: Journal of gastroenterology and hepatology 20110401
Title: Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110115
Title: A novel analysis method for diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry.
Journal: Analytical biochemistry 20101201
Title: [Autophagy of prostate cancer PC-3 cells under the induction of oridonin].
Journal: Zhonghua yi xue za zhi 20101116
Title: Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells.
Journal: Oncology reports 20100901
Title: Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.
Journal: Cancer letters 20100828
Title: Induction of G(2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells.
Journal: Journal of natural products 20100625
Title: Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system.
Journal: Journal of microencapsulation 20100501
Title: Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.
Journal: International journal of laboratory hematology 20100201
Title: Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB.
Journal: The Journal of pharmacology and experimental therapeutics 20100201
Title: Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line.
Journal: International journal of nanomedicine 20100101
Title: Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc.
Journal: BMC cancer 20100101
Title: [Empirical study of oridonin-induced gastric cancer cells MKN45 apoptosis].
Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20091101
Title: Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells.
Journal: Archives of biochemistry and biophysics 20091001
Title: [Preparation and characterization of oridonin submicron emulsions].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091001
Title: In vitro and in vivo antitumor activity of oridonin nanosuspension.
Journal: International journal of pharmaceutics 20090908
Title: NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.
Journal: Archives of biochemistry and biophysics 20090901
Title: Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats.
Journal: Chinese medical journal 20090620
Title: Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells.
Journal: Autophagy 20090401
Title: Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia.
Journal: International immunopharmacology 20090301
Title: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells.
Journal: The FEBS journal 20090301
Title: Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosis.
Journal: Biochemical and biophysical research communications 20090109
Title: Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin.
Journal: International journal of pharmaceutics 20090105
Title: [Study on stability of oridonin solution].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101
Title: The effect of stealth liposomes on pharmacokinetics, tissue distribution and anti-tumor activity of oridonin.
Journal: PDA journal of pharmaceutical science and technology 20090101
Title: Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.
Journal: Environmental health perspectives 20080901
Title: Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation.
Journal: Journal of pharmacological sciences 20080901
Title: [Release kinetics of oridonin self-microemulsifying drug delivery system in vitro].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901
Title: Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates.
Journal: Bioorganic & medicinal chemistry letters 20080815
Title: Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways.
Journal: Journal of pharmacological sciences 20080801
Title: Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death.
Journal: Archives of biochemistry and biophysics 20080715
Title: Oridonin-loaded poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) copolymer nanoparticles: preparation, characterization, and antitumor activity on mice with transplanted hepatoma.
Journal: Journal of drug targeting 20080701
Title: An HPLC method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615
Title: Characterization and in vivo evaluation of an inclusion complex of oridonin and 2-hydroxypropyl-beta-cyclodextrin.
Journal: Drug development and industrial pharmacy 20080601
Title: Preparation and evaluation of self-microemulsifying drug delivery system of oridonin.
Journal: International journal of pharmaceutics 20080501
Title: Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions.
Journal: International journal of pharmaceutics 20080501
Title: Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080401
Title: Down-regulation of androgen-receptor and PSA by phytochemicals.
Journal: International journal of oncology 20080201
Title: [Inhibitory effect of Oridonin injection on heterotransplanted gastric adenocarcinoma in nude mice and its mechanism].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080201
Title: Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway.
Journal: Journal of Asian natural products research 20080101
Title: Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling.
Journal: Journal of Asian natural products research 20080101
Title: Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.
Journal: Journal of pharmacological sciences 20071201
Title: Preparation and characterization of an oridonin nanosuspension for solubility and dissolution velocity enhancement.
Journal: Drug development and industrial pharmacy 20071201
Title: Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line.
Journal: Acta pharmacologica Sinica 20071101
Title: Authentication and chemical study of isodonis herba and isodonis extracts.
Journal: Chemical & pharmaceutical bulletin 20071101
Title: [Determination of oridonin and rosemarinic acid in Rabdosia rubescens by HPLC].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071101
Title: [Effects of Oridonin on proliferation in human nasopharyngeal carcinoma line CNE 2 in vitro].
Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20071001
Title: Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
Journal: Journal of pharmacological sciences 20070901
Title: Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra.
Journal: International immunopharmacology 20070701
Title: P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells.
Journal: Acta pharmacologica Sinica 20070701
Title: Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice.
Journal: Die Pharmazie 20070601
Title: Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells.
Journal: Biological & pharmaceutical bulletin 20070501
Title: Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
Journal: Blood 20070415
Title: Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo.
Journal: Cell research 20070401
Title: Effective two-dimensional counter-current chromatographic method for simultaneous isolation and purification of oridonin and ponicidin from the crude extract of Rabdosia rubescens.
Journal: Journal of chromatography. A 20070330
Title: Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells.
Journal: Cancer biology & therapy 20070201
Title: Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells.
Journal: Biological & pharmaceutical bulletin 20070201
Title: Studies on the oridonin-loaded poly(D,L-lactic acid) nanoparticles in vitro and in vivo.
Journal: International journal of biological macromolecules 20070130
Title: Determination of oridonin in rat plasma by reverse-phase high-performance liquid chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20070117
Title: Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway.
Journal: Journal of pharmacological sciences 20070101
Title: [Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070101
Title: Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma.
Journal: Acta pharmacologica Sinica 20061201
Title: Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway.
Journal: Journal of pharmacological sciences 20061101
Title: [Change of Bcl-2 expression and telomerase during apoptosis induced by oridonin on human hepatocelluar carcinoma cells].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061101
Title: Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells.
Journal: Biological & pharmaceutical bulletin 20060901
Title: A rapid HPLC/ESI-MS method for the quantitative determination of oridonin in rat plasma.
Journal: Die Pharmazie 20060901
Title: Augmentation of oridonin-induced apoptosis observed with reduced autophagy.
Journal: Journal of pharmacological sciences 20060701
Title: Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine,' is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
Journal: Cancer research 20060501
Title: Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells.
Journal: International immunopharmacology 20060201
Title: Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action.
Journal: American journal of hematology 20060201
Title: Isolation and purification of oridonin from Rabdosia rubescens using upright counter-current chromatography.
Journal: Journal of separation science 20060201
Title: The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells.
Journal: Journal of ethnopharmacology 20060116
Title: A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death.
Journal: Acta medica Okayama 20051201
Title: [Oridonin induced U937 cell apoptosis through ERK pathway].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051201
Title: Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.
Journal: Biochemical and biophysical research communications 20051111
Title: Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis.
Journal: Biological & pharmaceutical bulletin 20051101
Title: Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.
Journal: Journal of pharmacological sciences 20050801
Title: [The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050601
Title: Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
Journal: Molecular cancer therapeutics 20050401
Title: Apoptotic effect of oridonin on NB4 cells and its mechanism.
Journal: Leukemia & lymphoma 20050401
Title: The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.
Journal: International journal of oncology 20050301
Title: Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cells.
Journal: Biological & pharmaceutical bulletin 20050301
Title: Oridonin-induced apoptosis in leukemia K562 cells and its mechanism.
Journal: Neoplasma 20050101
Title: Antiproliferation effects of oridonin on HL-60 cells.
Journal: Annals of hematology 20041101
Title: [Regulation of telomerase activity and cell cycle of K562 cells by oridonin].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041101
Title: Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929.
Journal: Biological & pharmaceutical bulletin 20041001
Title: Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation.
Journal: Journal of pharmacological sciences 20041001
Title: Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome.
Journal: Journal of Asian natural products research 20040601
Title: Anti-proliferation effect of oridonin on HL-60 cells and its mechanism.
Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20040601
Title: Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway.
Journal: Acta pharmacologica Sinica 20040501
Title: Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
Journal: Journal of natural products 20040101
Title: Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action.
Journal: The Journal of international medical research 20040101
Title: Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.
Journal: International journal of oncology 20031001
Title: Taibaijaponicains C and D: two new diterpenoids from Isodon japonica.
Journal: Planta medica 20020501
Title: Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori.
Journal: Zentralblatt fur Bakteriologie : international journal of medical microbiology 19970601
Title: Song M, et al. Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0823.2017.
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