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2920-86-7,MFCD00056465
Catalog No.:AA002XLE

2920-86-7 | Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)-

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100mg
98%
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$234.00   $164.00
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500mg
98%
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$854.00   $598.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002XLE
Chemical Name:
Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)-
CAS Number:
2920-86-7
Molecular Formula:
C25H32O8
Molecular Weight:
460.5168
MDL Number:
MFCD00056465
SMILES:
OC(=O)CCC(=O)OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)C=C[C@]12C
Properties
Properties
 
Form:
Solid  
MP:
207 - 210°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
950  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
1.8  

Literature

Title: Comparison of simple Eudragit microparticles loaded with prednisolone and Eudragit-coated chitosan-succinyl-prednisolone conjugate microparticles: Part I. Particle characteristics and in vitro evaluation as a colonic delivery system.

Journal: Drug development and industrial pharmacy 20120701

Title: Prognostic evaluation of electrocochleography in idiopathic sudden sensorineural hearing loss.

Journal: Acta oto-laryngologica 20120201

Title: Intravenous immune globulin plus corticosteroids in refractory Kawasaki disease.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20111001

Title: Kinetic analysis of in vitro and in vivo release of prednisolone from the conjugate of glycol-chitosan and succinyl-prednisolone.

Journal: International journal of pharmaceutics 20110530

Title: Immediate-type hypersensitivity to succinylated corticosteroids.

Journal: International archives of allergy and immunology 20110101

Title: Effects of propranolol on the development of glucocorticoid-induced osteoporosis in male rats.

Journal: Pharmacological reports : PR 20110101

Title: A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves' orbitopathy.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20100101

Title: [Fever and back pain--a case report of spinal gout].

Journal: Deutsche medizinische Wochenschrift (1946) 20100101

Title: Vitreal kinetics of quinidine in rabbits in the presence of topically coadministered P-glycoprotein substrates/modulators.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090801

Title: Short-term etidronate treatment prevents glucocorticoid-induced bone debility of the mandible in growing rats.

Journal: Orthodontics & craniofacial research 20081101

Title: [Recognizing simple clinical signs. When is an asthma attack an emergency?].

Journal: MMW Fortschritte der Medizin 20080313

Title: Influence of glucocorticoid on bone in 3-, 6-, and 12-month-old rats as determined by bone mass and histomorphometry.

Journal: Modern rheumatology 20080101

Title: Oral steroid improves bullous pemphigoid-like clinical manifestations in non-Herlitz junctional epidermolysis bullosa with COL17A1 mutation.

Journal: The British journal of dermatology 20070901

Title: Impairment of angiogenic activity in the serum from patients with coronary aneurysms due to Kawasaki disease.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20070701

Title: [Quincke's edema: diagnosis and management of 102 patients with sudden upper airway obstruction].

Journal: Laryngo- rhino- otologie 20070601

Title: Intravitreal prednisolone sodium succinate reduces diabetic macular edema without intraocular pressure rise.

Journal: American journal of ophthalmology 20070101

Title: A multicenter prospective randomized trial of corticosteroids in primary therapy for Kawasaki disease: clinical course and coronary artery outcome.

Journal: The Journal of pediatrics 20060901

Title: Carnosine protects against the inactivation of esterase induced by glycation and a steroid.

Journal: Biochimica et biophysica acta 20050630

Title: Effects of different corticosteroids on the development of osteonecrosis in rabbits.

Journal: Rheumatology (Oxford, England) 20050301

Title: [Recurrence of a retrobulbar neuritis? Classic VEP and missing periocular pain].

Journal: Klinische Monatsblatter fur Augenheilkunde 20050101

Title: [Binaural auditory deficit during pregnancy].

Journal: HNO 20041001

Title: An alternative method of steroid-induced lens opacification in brown norway rat eyes applying systemic pulse administration.

Journal: Ophthalmic research 20040101

Title: [The different levels of prednisolone in perilymph after local and systemic treatment].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20031001

Title: The molecular chaperone, alpha-crystallin, protects against loss of antigenicity and activity of esterase caused by sugars, sugar phosphate and a steroid.

Journal: Biological chemistry 20030801

Title: [Comments on the contribution, 'Immunomodulating staged therapy of multiple sclerosis by the Multiple Sclerosis Therapy Consensus Group'].

Journal: Der Nervenarzt 20021201

Title: Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.

Journal: Journal of medicinal chemistry 20020718

Title: Is corticosteroid therapy effective for sudden-onset sensorineural hearing loss at lower frequencies?

Journal: Archives of otolaryngology--head & neck surgery 20020401

Title: The effect of modification of alpha-crystallin by prednisolone-21-hemisuccinate and fructose 6-phosphate on chaperone activity.

Journal: Developments in ophthalmology 20020101

Title: Prednisolone-appended alpha-cyclodextrin: alleviation of systemic adverse effect of prednisolone after intracolonic administration in 2,4,6-trinitrobenzenesulfonic acid-induced colitis rats.

Journal: Journal of pharmaceutical sciences 20011201

Title: Influence of steroids on microvascular perfusion injury of the bowel induced by extracorporeal circulation.

Journal: The Annals of thoracic surgery 20011001

Title: [Permeability of the round window membrane for prednisolone-21-hydrogen succinate. Prednisolone content of the perilymph after local administration vs. systemic injection].

Journal: HNO 20010701

Title: X-ray diffraction, differential scanning calorimetry and thermogravimetry combined with infrared analysis of freeze-dried prednisolone hemisuccinate.

Journal: Die Pharmazie 20010601

Title: Comparison of suppressive potency between prednisolone and prednisolone sodium succinate against mitogen-induced blastogenesis of human peripheral blood mononuclear cells in-vitro.

Journal: The Journal of pharmacy and pharmacology 20010501

Title: MR imaging findings in a dog with intravascular lymphoma in the brain.

Journal: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20010101

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Tags:2920-86-7 Molecular Formula|2920-86-7 MDL|2920-86-7 SMILES|2920-86-7 Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)-