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292634-27-6,MFCD30182318
Catalog No.:AA00BGLX

292634-27-6 | Dianicline

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10mg
≥98%(HPLC)
in stock  
$263.00   $184.00
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50mg
≥98%(HPLC)
in stock  
$913.00   $639.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BGLX
Chemical Name:
Dianicline
CAS Number:
292634-27-6
Molecular Formula:
C13H18Cl2N2O
Molecular Weight:
289.2008
MDL Number:
MFCD30182318
SMILES:
c1cnc2c(c1)O[C@@H]1[C@@]3(C2)CCN(C3)CC1.Cl.Cl
Properties
Computed Properties
 
Complexity:
296  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
1.4  

Literature

Title: Nicotine receptor partial agonists for smoking cessation.

Journal: The Cochrane database of systematic reviews 20120418

Title: Identification and subsequent removal of an interference by FAIMS in the bioanalysis of dianicline in animal plasma.

Journal: Bioanalysis 20110901

Title: Dianicline, a novel α4β2 nicotinic acetylcholine receptor partial agonist, for smoking cessation: a randomized placebo-controlled clinical trial.

Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110101

Title: Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

Journal: British journal of pharmacology 20100501

Title: Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Journal: Journal of medicinal chemistry 20050728

Title: SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.

Journal: The Journal of pharmacology and experimental therapeutics 20030701

Title: Tonstad S, et al. Dianicline, a novel α4β2 nicotinic acetylcholine receptor partial agonist, for smoking cessation: a randomized placebo-controlled clinical trial. Nicotine Tob Res. 2011 Jan;13(1):1-6.

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