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29745-04-8,MFCD00213361
Catalog No.:AA002Z7H

29745-04-8 | Norcantharidin, mixture of endo/exo

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250mg
98%
in stock  
$11.00   $8.00
- +
5g
95%
in stock  
$110.00   $77.00
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10g
95
in stock  
$208.00   $145.00
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50g
95
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002Z7H
Chemical Name:
Norcantharidin, mixture of endo/exo
CAS Number:
29745-04-8
Molecular Formula:
C8H8O4
Molecular Weight:
168.1467
MDL Number:
MFCD00213361
SMILES:
O=C1OC(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2O1
Properties
Properties
 
BP:
362.464°C at 760 mmHg  
Form:
Solid  
MP:
114-116°C  
Stability:
Moisture Sensitive  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
246  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
XLogP3:
-0.1  

Downstream Synthesis Route

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Literature

Title: Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway.

Journal: Environmental toxicology 20180301

Title: Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.

Journal: International journal of oncology 20121101

Title: Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1.

Journal: Cellular signalling 20120901

Title: Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells.

Journal: International journal of oncology 20120901

Title: Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction.

Journal: Chinese journal of integrative medicine 20120901

Title: Preparation, characterization and anticancer activity of norcantharidin-loaded poly(ethylene glycol)-poly(caprolactone) amphiphilic block copolymer micelles.

Journal: Die Pharmazie 20120901

Title: Synthesis and anticancer activity of a series of norcantharidin analogues.

Journal: European journal of medicinal chemistry 20120801

Title: Determination of norcantharidin in mouse tissues by liquid chromatography coupled to tandem mass spectrometry and its tissue distribution study.

Journal: Arzneimittel-Forschung 20120601

Title: Synthesis of optically pure norcantharidin analogue NCA-01, a highly selective protein phosphatase 2B inhibitor, and its derivatives.

Journal: Chemistry, an Asian journal 20120601

Title: Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.

Journal: International journal of oncology 20120501

Title: [Effect of norcantharidin on the expression of FN, Col IV and TGF-β1 mRNA and protein in HK-2 cells induced by high glucose].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120301

Title: [Effects of norcantharidin on lipopolysaccharide-induced hepatocyte injury in vitro].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120301

Title: Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis.

Journal: Molecular and cellular biochemistry 20120201

Title: Cantharidin and norcantharidin inhibit caprine luteal cell steroidogenesis in vitro.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120101

Title: Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/β-catenin signaling.

Journal: Journal of neuro-oncology 20120101

Title: Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.

Journal: PloS one 20120101

Title: Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer.

Journal: Asian Pacific journal of cancer prevention : APJCP 20120101

Title: Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers.

Journal: International journal of nanomedicine 20120101

Title: Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells.

Journal: PloS one 20120101

Title: Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS.

Journal: International journal of nanomedicine 20120101

Title: Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.

Journal: International journal of nanomedicine 20120101

Title: Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages.

Journal: PloS one 20120101

Title: Norcantharidin inhibits proliferation and fibronectin expression of HK-2 cells induced by albumin in vitro.

Journal: Cell biology international 20111201

Title: Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway.

Journal: Laboratory investigation; a journal of technical methods and pathology 20111201

Title: Norcantharidin induces melanoma cell apoptosis through activation of TR3 dependent pathway.

Journal: Cancer biology & therapy 20111201

Title: [Norcantharidin potentialize the chemosensitivity of adriamycin through the NF-κB/IκBα signaling pathway].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111201

Title: 3A4, a new potential target for B and myeloid lineage leukemias.

Journal: Journal of drug targeting 20111101

Title: Norcantharidin analogues: a patent review (2006 - 2010).

Journal: Expert opinion on therapeutic patents 20111101

Title: Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival.

Journal: Transplantation 20111027

Title: Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.

Journal: Bioorganic & medicinal chemistry 20110915

Title: Separation and identification of norcantharidin metabolites in vivo by GC-MS method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615

Title: Norcantharidin analogues with nematocidal activity in Haemonchus contortus.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: Norcantharidin induces apoptosis of breast cancer cells: involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401

Title: Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110201

Title: The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture.

Journal: Molecular biology reports 20110101

Title: Norcantharidin attenuates tubulointerstitial fibrosis in rat models with diabetic nephropathy.

Journal: Renal failure 20110101

Title: The antiplasmodial activity of norcantharidin analogs.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro.

Journal: Journal of drug targeting 20101101

Title: Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20101001

Title: Study on norcantharidin-induced apoptosis in SMMC-7721 cells through mitochondrial pathways.

Journal: Chinese journal of integrative medicine 20101001

Title: [Molecular mechanism of norcantharidin inducing apoptosis in liver cancer cells].

Journal: Zhonghua yi xue za zhi 20100810

Title: Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20100801

Title: [Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

Title: Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20100401

Title: Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401

Title: [Norcantharidin induces apoptosis in SMMC-7721 cells via the c-Jun-NH2-terminal kinase signaling pathways].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100201

Title: [Inhibition of the replication of HIV-1 by norcantharidin in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100201

Title: Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells.

Journal: Journal of experimental & clinical cancer research : CR 20100101

Title: Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway.

Journal: Cancer science 20091201

Title: A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells.

Journal: Chemico-biological interactions 20091030

Title: Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect.

Journal: Life sciences 20091021

Title: Synthesis, characterization, DNA-binding and antiproliferative activity of Nd(III) complexes with N-(nitrogen heterocyclic) norcantharidin acylamide acid.

Journal: Journal of fluorescence 20090901

Title: Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.

Journal: Journal of medicinal chemistry 20090813

Title: The effect of cantharidins on leukemic stem cells.

Journal: International journal of cancer 20090501

Title: Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells.

Journal: Life sciences 20090213

Title: Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Journal: ChemMedChem 20081201

Title: Formation mechanism and release behavior of poly(epsilon-caprolactone) microspheres containing disodium norcantharidate.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801

Title: [Preparation of the immunotoxin 2E8-norcantharidin and its targeting killing effect in vitro].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20080701

Title: Disodium norcantharidate-loaded poly(epsilon-caprolactone) microspheres II. Modification of morphology and release behavior.

Journal: International journal of pharmaceutics 20080402

Title: Disodium norcantharidate loaded poly(epsilon-caprolactone) microspheres I. Preparation and evaluation.

Journal: International journal of pharmaceutics 20080227

Title: [Synthesis and anticancer activity of norcantharidin-galactose derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080201

Title: Determination and pharmacokinetic study of norcantharidin in human serum by HPLC-MS/MS method.

Journal: Biomedical chromatography : BMC 20080101

Title: Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells.

Journal: Anti-cancer drugs 20080101

Title: Norcantharidin ameliorates proteinuria, associated tubulointerstitial inflammation and fibrosis in protein overload nephropathy.

Journal: American journal of nephrology 20080101

Title: Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070901

Title: Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.

Journal: Bioorganic & medicinal chemistry letters 20070615

Title: [Pharmacokinetics and biodistribution of 3H-norcantharidin in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070501

Title: [Effect of norcantharidin's derivative Nd3 on proliferation of human ovarian cancer cell line SKOV3 and its possible mechanisms].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20070401

Title: Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20070201

Title: [Comparison of acute toxicity of two preparations of norcantharidin in mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101

Title: Novel polymeric microspheres containing norcantharidin for chemoembolization.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20061101

Title: A less irritant norcantharidin lipid microspheres: formulation and drug distribution.

Journal: International journal of pharmaceutics 20061012

Title: [In vitro and in vivo assesemet of sodium norcantharidin lipid microsphere].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801

Title: [Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060701

Title: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20060501

Title: [Effects of norcantharidin on angiogenesis of human gallbladder carcinoma and its anti-angiogenic mechanisms].

Journal: Zhonghua yi xue za zhi 20060314

Title: Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells.

Journal: Anti-cancer drugs 20060301

Title: Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells.

Journal: World journal of gastroenterology 20050428

Title: Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells.

Journal: Anti-cancer drugs 20050301

Title: Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C.

Journal: Chinese medical journal 20050205

Title: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio.

Journal: Cancer letters 20050110

Title: In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin.

Journal: Basic & clinical pharmacology & toxicology 20050101

Title: An investigation on liver-targeting microemulsions of norcantharidin.

Journal: Drug delivery 20050101

Title: Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK, and mitochondrial pathways.

Journal: Acta pharmacologica Sinica 20041101

Title: Influence of norcantharidin on proliferation, proliferation-related gene proteins proliferating cell nuclear antigen and Ki-67 of human gallbladder carcinoma GBC-SD cells.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20041101

Title: Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways.

Journal: Journal of Korean medical science 20040801

Title: [Studies on the liver targeting of norcantharindin microemulsion].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801

Title: [The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040501

Title: Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Journal: Bioorganic & medicinal chemistry letters 20040419

Title: Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells.

Journal: British journal of pharmacology 20031001

Title: [Advances in the study of Cantharidin and its derivatives].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030601

Title: Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes.

Journal: Oral oncology 20030101

Title: Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.

Journal: International journal of cancer 20020710

Title: Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand.

Journal: Journal of cancer research and clinical oncology 20020401

Title: Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

Journal: Journal of medicinal chemistry 20020314

Title: Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

Journal: Bioorganic & medicinal chemistry letters 20011119

Title: Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety.

Journal: Journal of medicinal chemistry 20010621

Title: Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells.

Journal: The American journal of Chinese medicine 20010101

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Tags:29745-04-8 Molecular Formula|29745-04-8 MDL|29745-04-8 SMILES|29745-04-8 Norcantharidin, mixture of endo/exo