[1]ChemicalandPharmaceuticalBulletin,1991,vol.39,p.2288-2300
[2]BioorganicandMedicinalChemistryLetters,1997,vol.7,p.1833-1836
[3]JournaloftheAmericanChemicalSociety,2003,vol.125,p.9740-9749
[4]Lettersindrugdesignanddiscovery,2011,vol.8,p.568-574
[5]RSCAdvances,2014,vol.4,p.56743-56748
[6]SyntheticCommunications,2011,vol.41,p.2769-2793
[7]GreenChemistry,2013,vol.15,p.1318-1325
[8]DaltonTransactions,2016,vol.45,p.7737-7747
[9]Patent:CN111253415,2020,A.Locationinpatent:Paragraph0043-0045
[10]Patent:CN111303179,2020,A.Locationinpatent:Paragraph0038-0039
[11]Patent:CN111362962,2020,A.Locationinpatent:Paragraph0042-0043
[12]OrganicPreparationsandProceduresInternational,1999,vol.31,p.220-222
[13]JournalofOrganicChemistry,1982,vol.47,p.3953-3959
[14]MedicinalChemistry,2014,vol.10,p.376-381
[15]Molecules,2014,vol.19,p.6911-6928
[16]Patent:JP2016/98200,2016,A.Locationinpatent:Paragraph0064;0066
[17]Patent:TW2016/18771,2016,A.Locationinpatent:Paragraph0069-0072;0078;0079
[18]AdvancedSynthesisandCatalysis,2003,vol.345,p.996-1004
[19]MedicinalChemistryResearch,2018,vol.27,p.406-411
[20]Patent:CN109575051,2019,A.Locationinpatent:Paragraph0022;0025;0026
[21]NewJournalofChemistry,2008,vol.32,p.28-36
[22]ZhurnalObshcheiKhimii,1956,vol.26,p.213,216;engl.Ausg.S.227,230
[23]JournaloftheChemicalSociety.PerkintransactionsI,1990,p.3209-3210
[24]JournalofOrganicChemistry,1998,vol.63,p.1190-1197
[25]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.1687-1690
[26]OrganicLetters,2001,vol.3,p.545-548
[27]JournalofOrganicChemistry,2000,vol.65,p.6984-6991
[28]JournalofOrganicChemistry,2008,vol.73,p.151-156
[29]TetrahedronLetters,2011,vol.52,p.1583-1586
[30]BioorganicandMedicinalChemistry,2011,vol.19,p.5734-5741
[31]EuropeanJournalofMedicinalChemistry,2012,vol.54,p.573-581
[32]BioorganicandMedicinalChemistryLetters,2015,vol.25,p.363-366
[33]Patent:CN110862403,2020,A.Locationinpatent:Paragraph0029-0031
[1]Patent:CN109867661,2019,A.Locationinpatent:Paragraph0284;0286
[2]BioorganicandMedicinalChemistry,2007,vol.15,p.6126-6134
[3]ZhurnalObshcheiKhimii,1959,vol.29,p.1358,1362;engl.Ausg.S.1334,1337
[4]JournalofMedicinalChemistry,1963,vol.6,p.802-805
[1]JournaloftheChemicalSociety.PerkintransactionsI,1990,p.3209-3210
[2]CanadianJournalofChemistry,1984,vol.62,p.2578-2582
[3]JournaloftheChemicalSociety,1960,p.1541-1547
[4]OrganicLetters,2001,vol.3,p.545-548
[5]AnnalesdeChimie(Cachan,France),1960,vol.<13>5,p.1165,1187 ComptesRendusHebdomadairesdesSeancesdel'AcademiedesSciences,1956,vol.243,p.2085
[6]Patent:US2020/17461,2020,A1.Locationinpatent:Paragraph1881-1882
[1]BioorganicandMedicinalChemistry,2007,vol.15,p.6126-6134
[2]SyntheticCommunications,2000,vol.30,p.3527-3533
[3]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.3277-3281
[4]BioorganicandMedicinalChemistry,2011,vol.19,p.5734-5741
[5]JournaloftheAmericanChemicalSociety,2005,vol.127,p.2966-2973
[6]JournalofMedicinalChemistry,1963,vol.6,p.802-805
[1]Mantovani,Giuseppe;Lecolley,Francois;Tao,Lei;Haddleton,DavidM.;Clerx,Joost;Cornelissen,JeroenJ.L.M.;Velonia,Kelly[JournaloftheAmericanChemicalSociety,2005,vol.127,#9,p.2966-2973]
[2]Jones,J.Bryan;Francis,ChristopherJ.[CanadianJournalofChemistry,1984,vol.62,p.2578-2582]
[3]Stewart,ScottG.;Hill,TimothyA.;Gilbert,Jayne;Ackland,StephenP.;Sakoff,JennetteA.;McCluskey,Adam[BioorganicandMedicinalChemistry,2007,vol.15,#23,p.7301-7310]
[4]Locationinpatent:schemeortableTarleton,Mark;Bernhardt,PaulV.;McCluskey,Adam[JournalofChemicalCrystallography,2012,vol.42,#6,p.639-644]
[5]CurrentPatentAssignee:SHAOXINGUNIVERSITY-CN103554123,2016,BLocationinpatent:Paragraph0018;0036
[6]CurrentPatentAssignee:SHAOXINGUNIVERSITY-CN106083966,2016,ALocationinpatent:Paragraph0028;0029
[7]CurrentPatentAssignee:SHAOXINGUNIVERSITY-CN106008634,2016,ALocationinpatent:Paragraph0032;0033;0034
Title: Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway.
Journal: Environmental toxicology 20180301
Title: Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.
Journal: International journal of oncology 20121101
Title: Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1.
Journal: Cellular signalling 20120901
Title: Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells.
Journal: International journal of oncology 20120901
Title: Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction.
Journal: Chinese journal of integrative medicine 20120901
Title: Preparation, characterization and anticancer activity of norcantharidin-loaded poly(ethylene glycol)-poly(caprolactone) amphiphilic block copolymer micelles.
Journal: Die Pharmazie 20120901
Title: Synthesis and anticancer activity of a series of norcantharidin analogues.
Journal: European journal of medicinal chemistry 20120801
Title: Determination of norcantharidin in mouse tissues by liquid chromatography coupled to tandem mass spectrometry and its tissue distribution study.
Journal: Arzneimittel-Forschung 20120601
Title: Synthesis of optically pure norcantharidin analogue NCA-01, a highly selective protein phosphatase 2B inhibitor, and its derivatives.
Journal: Chemistry, an Asian journal 20120601
Title: Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.
Journal: International journal of oncology 20120501
Title: [Effect of norcantharidin on the expression of FN, Col IV and TGF-β1 mRNA and protein in HK-2 cells induced by high glucose].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120301
Title: [Effects of norcantharidin on lipopolysaccharide-induced hepatocyte injury in vitro].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120301
Title: Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis.
Journal: Molecular and cellular biochemistry 20120201
Title: Cantharidin and norcantharidin inhibit caprine luteal cell steroidogenesis in vitro.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120101
Title: Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/β-catenin signaling.
Journal: Journal of neuro-oncology 20120101
Title: Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.
Journal: PloS one 20120101
Title: Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers.
Journal: International journal of nanomedicine 20120101
Title: Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells.
Journal: PloS one 20120101
Title: Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS.
Journal: International journal of nanomedicine 20120101
Title: Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.
Journal: International journal of nanomedicine 20120101
Title: Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages.
Journal: PloS one 20120101
Title: Norcantharidin inhibits proliferation and fibronectin expression of HK-2 cells induced by albumin in vitro.
Journal: Cell biology international 20111201
Title: Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway.
Journal: Laboratory investigation; a journal of technical methods and pathology 20111201
Title: Norcantharidin induces melanoma cell apoptosis through activation of TR3 dependent pathway.
Journal: Cancer biology & therapy 20111201
Title: [Norcantharidin potentialize the chemosensitivity of adriamycin through the NF-κB/IκBα signaling pathway].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111201
Title: 3A4, a new potential target for B and myeloid lineage leukemias.
Journal: Journal of drug targeting 20111101
Title: Norcantharidin analogues: a patent review (2006 - 2010).
Journal: Expert opinion on therapeutic patents 20111101
Title: Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival.
Journal: Transplantation 20111027
Title: Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.
Journal: Bioorganic & medicinal chemistry 20110915
Title: Separation and identification of norcantharidin metabolites in vivo by GC-MS method.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615
Title: Norcantharidin analogues with nematocidal activity in Haemonchus contortus.
Journal: Bioorganic & medicinal chemistry letters 20110601
Title: Norcantharidin induces apoptosis of breast cancer cells: involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401
Title: Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110201
Title: The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture.
Journal: Molecular biology reports 20110101
Title: Norcantharidin attenuates tubulointerstitial fibrosis in rat models with diabetic nephropathy.
Journal: Renal failure 20110101
Title: The antiplasmodial activity of norcantharidin analogs.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro.
Journal: Journal of drug targeting 20101101
Title: Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20101001
Title: Study on norcantharidin-induced apoptosis in SMMC-7721 cells through mitochondrial pathways.
Journal: Chinese journal of integrative medicine 20101001
Title: [Molecular mechanism of norcantharidin inducing apoptosis in liver cancer cells].
Journal: Zhonghua yi xue za zhi 20100810
Title: Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo.
Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20100801
Title: [Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801
Title: Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery.
Journal: Nanomedicine : nanotechnology, biology, and medicine 20100401
Title: Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401
Title: [Norcantharidin induces apoptosis in SMMC-7721 cells via the c-Jun-NH2-terminal kinase signaling pathways].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100201
Title: [Inhibition of the replication of HIV-1 by norcantharidin in vitro].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100201
Title: Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells.
Journal: Journal of experimental & clinical cancer research : CR 20100101
Title: Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway.
Journal: Cancer science 20091201
Title: A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells.
Journal: Chemico-biological interactions 20091030
Title: Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect.
Journal: Life sciences 20091021
Title: Synthesis, characterization, DNA-binding and antiproliferative activity of Nd(III) complexes with N-(nitrogen heterocyclic) norcantharidin acylamide acid.
Journal: Journal of fluorescence 20090901
Title: Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.
Journal: Journal of medicinal chemistry 20090813
Title: The effect of cantharidins on leukemic stem cells.
Journal: International journal of cancer 20090501
Title: Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells.
Journal: Life sciences 20090213
Title: Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.
Journal: ChemMedChem 20081201
Title: Formation mechanism and release behavior of poly(epsilon-caprolactone) microspheres containing disodium norcantharidate.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801
Title: [Preparation of the immunotoxin 2E8-norcantharidin and its targeting killing effect in vitro].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20080701
Title: Disodium norcantharidate-loaded poly(epsilon-caprolactone) microspheres II. Modification of morphology and release behavior.
Journal: International journal of pharmaceutics 20080402
Title: Disodium norcantharidate loaded poly(epsilon-caprolactone) microspheres I. Preparation and evaluation.
Journal: International journal of pharmaceutics 20080227
Title: [Synthesis and anticancer activity of norcantharidin-galactose derivatives].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080201
Title: Determination and pharmacokinetic study of norcantharidin in human serum by HPLC-MS/MS method.
Journal: Biomedical chromatography : BMC 20080101
Title: Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells.
Journal: Anti-cancer drugs 20080101
Title: Norcantharidin ameliorates proteinuria, associated tubulointerstitial inflammation and fibrosis in protein overload nephropathy.
Journal: American journal of nephrology 20080101
Title: Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.
Journal: Bioorganic & medicinal chemistry 20071201
Title: Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.
Journal: Bioorganic & medicinal chemistry 20070915
Title: Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070901
Title: Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.
Journal: Bioorganic & medicinal chemistry letters 20070615
Title: [Pharmacokinetics and biodistribution of 3H-norcantharidin in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070501
Title: [Effect of norcantharidin's derivative Nd3 on proliferation of human ovarian cancer cell line SKOV3 and its possible mechanisms].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20070401
Title: Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro.
Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20070201
Title: [Comparison of acute toxicity of two preparations of norcantharidin in mice].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101
Title: Novel polymeric microspheres containing norcantharidin for chemoembolization.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20061101
Title: A less irritant norcantharidin lipid microspheres: formulation and drug distribution.
Journal: International journal of pharmaceutics 20061012
Title: [In vitro and in vivo assesemet of sodium norcantharidin lipid microsphere].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801
Title: [Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060701
Title: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo].
Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20060501
Title: [Effects of norcantharidin on angiogenesis of human gallbladder carcinoma and its anti-angiogenic mechanisms].
Journal: Zhonghua yi xue za zhi 20060314
Title: Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells.
Journal: Anti-cancer drugs 20060301
Title: Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells.
Journal: World journal of gastroenterology 20050428
Title: Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells.
Journal: Anti-cancer drugs 20050301
Title: Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C.
Journal: Chinese medical journal 20050205
Title: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio.
Journal: Cancer letters 20050110
Title: In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin.
Journal: Basic & clinical pharmacology & toxicology 20050101
Title: An investigation on liver-targeting microemulsions of norcantharidin.
Journal: Drug delivery 20050101
Title: Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK, and mitochondrial pathways.
Journal: Acta pharmacologica Sinica 20041101
Title: Influence of norcantharidin on proliferation, proliferation-related gene proteins proliferating cell nuclear antigen and Ki-67 of human gallbladder carcinoma GBC-SD cells.
Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20041101
Title: Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways.
Journal: Journal of Korean medical science 20040801
Title: [Studies on the liver targeting of norcantharindin microemulsion].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801
Title: [The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040501
Title: Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.
Journal: Bioorganic & medicinal chemistry letters 20040419
Title: Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells.
Journal: British journal of pharmacology 20031001
Title: [Advances in the study of Cantharidin and its derivatives].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030601
Title: Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes.
Journal: Oral oncology 20030101
Title: Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.
Journal: International journal of cancer 20020710
Title: Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand.
Journal: Journal of cancer research and clinical oncology 20020401
Title: Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.
Journal: Journal of medicinal chemistry 20020314
Title: Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.
Journal: Bioorganic & medicinal chemistry letters 20011119
Title: Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety.
Journal: Journal of medicinal chemistry 20010621
Title: Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells.
Journal: The American journal of Chinese medicine 20010101