29767-20-2,MFCD00866516
Catalog No.:AA00I5FJ

29767-20-2 | 5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
10mg
98%(HPLC)
in stock  
$42.00   $29.00
- +
25mg
98%(HPLC)
in stock  
$58.00   $40.00
- +
50mg
98%(HPLC)
in stock  
$83.00   $58.00
- +
100mg
98%(HPLC)
in stock  
$150.00   $105.00
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1g
98%
in stock  
$656.00   $459.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00I5FJ
Chemical Name:
5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
CAS Number:
29767-20-2
Molecular Formula:
C32H32O13S
Molecular Weight:
656.6537
MDL Number:
MFCD00866516
SMILES:
COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)O[C@@H]1O[C@@H]2CO[C@H](O[C@H]2[C@@H]([C@H]1O)O)c1cccs1
Properties
Computed Properties
 
Complexity:
1090  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.2  

Downstream Synthesis Route
20898-85-5    29767-20-2   
9-(4,6-O-(thien-2-ylmethylidene-Β-D-glucopyranosyl)oxy)-5,8,9a,9-tetrahydro-5-(4-(5-nitrothien-2-yl)methoxy)3,5-dimethoxyphenylfuro3',4':6,7naphtha2,3-d-1,3-dioxol-6(5aH)-one 

[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn26

74786-64-4    29767-20-2   
9-(4,6-O-(thien-2-ylmethylidene-Β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-(1-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo3',4':6,7naphtha2,3-d-1,3-dioxol-6(5aH)-one 

[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn27

9-(4,6-O-(thien-2-ylmethylidene-Β-D-glucopyranosyl)oxy)-5,8,9a,9-tetrahydro-5-(4-(5-nitrothien-2-yl)methoxy)3,5-dimethoxyphenylfuro3',4':6,7naphtha2,3-d-1,3-dioxol-6(5aH)-one 
  29767-20-2 

[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn20-21

C9H6FNO2S2 
  29767-20-2   
C41H36FNO14S3 
 
C41H36FNO14S3 

[1]JournalofMedicinalChemistry,2020,vol.63,p.2877-2893

C9H6FNO2S2 
  29767-20-2   
C50H40F2N2O15S5 

[1]JournalofMedicinalChemistry,2020,vol.63,p.2877-2893

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Tags:29767-20-2 Molecular Formula|29767-20-2 MDL|29767-20-2 SMILES|29767-20-2 5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Catalog No.: AA00I5FJ
29767-20-2,MFCD00866516
29767-20-2 | 5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Pack Size: 1mg
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 10mg
Purity: 98%(HPLC)
in stock
$42.00 $29.00
Pack Size: 25mg
Purity: 98%(HPLC)
in stock
$58.00 $40.00
Pack Size: 50mg
Purity: 98%(HPLC)
in stock
$83.00 $58.00
Pack Size: 100mg
Purity: 98%(HPLC)
in stock
$150.00 $105.00
Pack Size: 1g
Purity: 98%
in stock
$656.00 $459.00
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Technical Information
Catalog Number: AA00I5FJ
Chemical Name: 5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
CAS Number: 29767-20-2
Molecular Formula: C32H32O13S
Molecular Weight: 656.6537
MDL Number: MFCD00866516
SMILES: COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)O[C@@H]1O[C@@H]2CO[C@H](O[C@H]2[C@@H]([C@H]1O)O)c1cccs1
Properties
Complexity: 1090  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 10  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 46  
Hydrogen Bond Acceptor Count: 14  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.2  
Downstream Synthesis Route
20898-85-5    29767-20-2   
9-(4,6-O-(thien-2-ylmethylidene-Β-D-glucopyranosyl)oxy)-5,8,9a,9-tetrahydro-5-(4-(5-nitrothien-2-yl)methoxy)3,5-dimethoxyphenylfuro3',4':6,7naphtha2,3-d-1,3-dioxol-6(5aH)-one 

[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn26

74786-64-4    29767-20-2   
9-(4,6-O-(thien-2-ylmethylidene-Β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-(1-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo3',4':6,7naphtha2,3-d-1,3-dioxol-6(5aH)-one 

[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn27

9-(4,6-O-(thien-2-ylmethylidene-Β-D-glucopyranosyl)oxy)-5,8,9a,9-tetrahydro-5-(4-(5-nitrothien-2-yl)methoxy)3,5-dimethoxyphenylfuro3',4':6,7naphtha2,3-d-1,3-dioxol-6(5aH)-one 
  29767-20-2 

[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn20-21

C9H6FNO2S2 
  29767-20-2   
C41H36FNO14S3 
 
C41H36FNO14S3 

[1]JournalofMedicinalChemistry,2020,vol.63,p.2877-2893

C9H6FNO2S2 
  29767-20-2   
C50H40F2N2O15S5 

[1]JournalofMedicinalChemistry,2020,vol.63,p.2877-2893

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Title: Identification of potential surrogate end points in randomized clinical trials of aggressive and indolent non-Hodgkin's lymphoma: correlation of complete response, time-to-event and overall survival end points.

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Title: [Review on biosynthesis of podophyllotoxin].

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Title: Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness.

Journal: Molecular pharmacology20110401

Title: Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy.

Journal: Medical oncology (Northwood, London, England)20110301

Title: miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines.

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Title: Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells.

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Title: [Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].

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Title: Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

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Title: Andrographolide: a new plant-derived antineoplastic entity on horizon.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Cytogenetic instability in childhood acute lymphoblastic leukemia survivors.

Journal: Journal of biomedicine & biotechnology20110101

Title: A novel paclitaxel microemulsion containing a reduced amount of Cremophor EL: pharmacokinetics, biodistribution, and in vivo antitumor efficacy and safety.

Journal: Journal of biomedicine & biotechnology20110101

Title: The use of endophytes to obtain bioactive compounds and their application in biotransformation process.

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Title: Thermoreversible Pluronic F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies.

Journal: International journal of nanomedicine20110101

Title: Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees.

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Title: Management of provoked seizure.

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Title: Antiproliferation and cell apoptosis inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines.

Journal: Cell division20110101

Title: Promising molecular targeted therapies in breast cancer.

Journal: Indian journal of pharmacology20110101

Title: Treatment of HIV-related primary central nervous system lymphoma with AZT high dose, HAART, interleukin-2 and foscarnet in three patients.

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Title: Novel molecular markers of malignancy in histologically normal and benign breast.

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Title: Synthetic and application perspectives of azapodophyllotoxins: alternative scaffolds of podophyllotoxin.

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Title: Effect of imatinib on the biochemical parameters of the reproductive function in male Swiss albino mice.

Journal: Indian journal of pharmacology20110101

Title: An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II.

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Title: Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations.

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Title: Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia.

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Title: Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.

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Title: Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS.

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Title: Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.

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Title: CCND1 as a predictive biomarker of neoadjuvant chemotherapy in patients with locally advanced head and neck squamous cell carcinoma.

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Title: Small cell carcinoma of the renal pelvis: a case report and review of the literature.

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Title: Therapy-related myeloid malignancies in myeloma.

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Title: Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons.

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Title: Study on the proliferation and drug-resistance of human brain tumor stem-like cells.

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Title: Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.

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Title: The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, reexposure, and desensitization.

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Title: A QSAR study on the cytotoxicity of podophyllotoxin analogues against various cancer cell lines.

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Title: Treatment options for small cell lung cancer - do we have more choice?

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Title: Predictive value of (18)F-FDG hybrid PET/CT for the clinical outcome in patients with non-Hodgkin's lymphoma prior to and after autologous stem cell transplantation.

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Title: The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline.

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Title: The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline.

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Title: Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index.

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Title: Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

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Title: Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.

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Title: Decreasing expression of the interleukin-13 receptor IL-13Ralpha2 in treated recurrent malignant gliomas.

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Title: Temozolomide in malignant glioma.

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Title: Production of podophyllotoxin in Linum linearifolium in vitro cultures.

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Title: Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone.

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Title: Ayurveda and cancer.

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Title: Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.

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Title: 4-Des-oxy-4β-(4-methoxy-carbonyl-1,2,3-triazol-1-yl)podophyllotoxin dichloro-methane solvate.

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Title: Determination of teniposide in rat plasma by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry after intravenous administration.

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Title: MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme.

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Title: Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy.

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Title: Chemical stability of teniposide in aqueous and parenteral lipid emulsions.

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Title: Cytogenetic and molecular analysis of MLL rearrangements in acute lymphoblastic leukaemia survivors.

Journal: Mutagenesis20090301

Title: Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability.

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Title: A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer.

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Title: [Microsurgical strategies of glioma located in lateral fissure area].

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Title: A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.

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Title: Nimustine (ACNU) plus teniposide (VM26) in recurrent glioblastoma.

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Title: The role of biotechnology in the production of the anticancer compound podophyllotoxin.

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Title: Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

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Title: DNA-AP sites generation by etoposide in whole blood cells.

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Title: The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target.

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Title: Drug-induced hematologic syndromes.

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Title: Chenopodium album prevents progression of cell growth and enhances cell toxicity in human breast cancer cell lines.

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Title: Rituximab in the treatment of non-Hodgkin's lymphoma.

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Title: Adult Burkitt lymphoma: advances in diagnosis and treatment.

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Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

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Title: Quality of life in brain metastases radiation trials: a literature review.

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Title: Impact of rituximab and/or high-dose therapy with autotransplant at time of relapse in patients with follicular lymphoma: a GELA study.

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Title: CYP450 pharmacogenetics for personalizing cancer therapy.

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Title: Prophylactic G-CSF and antibiotics enable a significant dose-escalation of triplet-chemotherapy in non-small cell lung cancer.

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Title: [Treatment outcome of primary central nervous system germ cell tumors after combined therapy: a report of 23 cases].

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Title: Absent immunoglobulins in HIV-related Burkitt lymphoma/leukaemia.

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Title: The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats.

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Title: A systematic review of quality of life associated with standard chemotherapy regimens for advanced non-small cell lung cancer.

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Title: Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.

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Title: Non-Hodgkin's lymphoma in the elderly. Part 2: treatment of diffuse aggressive lymphomas.

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Title: GAMEC--a new intensive protocol for untreated poor prognosis and relapsed or refractory germ cell tumours.

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Title: Single nucleotide polymorphisms and expression of ERCC1 and ERCC2 vis-à-vis chemotherapy drug cytotoxicity in human glioma.

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Title: Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors.

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Title: Retinoblastoma in children older than 5 years of age.

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Title: Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.

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Title: The decatenation checkpoint.

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Title: Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life.

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Title: The altered apoptotic pathways in cisplatin and etoposide-resistant melanoma cells are drug specific.

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Title: Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.

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Title: Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma.

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Title: A case of fusariosis in an immunocompromised patient successfully treated with liposomal amphotericin B.

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Title: Glioblastoma multiforme with oligodendroglial component (GBMO): favorable outcome after post-operative radiotherapy and chemotherapy with nimustine (ACNU) and teniposide (VM26).

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Title: Natural microbial polysaccharide sulphoethyl glucan as antigenotoxic and cancer preventing agent.

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Title: Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta.

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Title: Front-line paclitaxel and irinotecan combination chemotherapy in advanced non-small-cell lung cancer: a phase I-II trial.

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Title: Plant-based anticancer molecules: a chemical and biological profile of some important leads.

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Title: Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia.

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Title: Second primary malignancies after treatment for malignant lymphoma.

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Title: Stage 4 neuroblastoma: sequential hemi-body irradiation or high-dose chemotherapy plus autologous haemopoietic stem cell transplantation to consolidate primary treatment.

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Title: High-dose therapy followed by autologous purged stem-cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by GOELAMS.

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Title: [VPC regimen combined with whole-brain radiotherapy in the treatment of small cell lung cancer with brain metastasis].

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Title: Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.

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Title: Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response.

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Title: Gemcitabine twice weekly as a radiosensitiser for the treatment of brain metastases in patients with carcinoma: a phase I study.

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Title: Chemotherapy for retinoblastoma.

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Title: Toxicity of the topoisomerase II inhibitors.

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Title: Clinical practice guideline on the optimal radiotherapeutic management of brain metastases.

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Title: Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.

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Title: Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma.

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Title: ATP-binding cassette (ABC) transporters in normal and pathological lung.

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Title: Cardiotoxicity of cancer chemotherapy: implications for children.

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Title: ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.

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Title: Inhibition of DNA topoisomerase II in living cells stimulates illegitimate recombination.

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Title: [Glioblastoma multiforme of the optic nerve].

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Title: Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.

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Title: Bone marrow transplantation for therapy-related acute myeloid leukemia in congenital retinoblastoma associated with 13q deletion syndrome.

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Title: Regulation of DNaseY activity by actinin-alpha4 during apoptosis.

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Title: [Primary central nervous system lymphoma: a report of 28 patients].

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Title: [Chemotherapy with higher or lower dose of teniposide combined with cisplatin and pingyangmycin for oral squamous cell carcinoma].

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Title: Autologous stem cell transplantation following induction therapy with an anthracycline-based regimen including interferon-alpha for low-grade non-Hodgkin's lymphoma.

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Title: Long-term efficacy of the CHVmP/BV regimen used for aggressive non-Hodgkin's lymphoma in three randomised EORTC trials.

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Title: Cognitive status and quality of life after treatment for primary CNS lymphoma.

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Title: Vincristine, cisplatin, teniposide, and cyclophosphamide combination in the treatment of recurrent or metastatic adrenocortical cancer.

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Title: Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells.

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Title: Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities.

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Title: Preradiation chemotherapy with VM-26 and CCNU in patients with glioblastoma multiforme.

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Title: High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962.

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Title: Carboplatin and teniposide as third-line chemotherapy in patients with recurrent oligodendroglioma or oligoastrocytoma: a phase II study.

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Title: [Evaluation of efficacy of treatment for 30 children with neuroblastoma].

Journal: Ai zheng = Aizheng = Chinese journal of cancer20031201

Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

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Title: [Chemosensitivity testing of oral squamous cell carcinomas with teniposide].

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology20031101

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Title: Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20031001

Title: P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.

Journal: Brain pathology (Zurich, Switzerland)20031001

Title: Extraocular retinoblastoma: a 13-year experience.

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Title: Effect of Aplidin in acute lymphoblastic leukaemia cells.

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Title: Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide.

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Title: Interactions between antiepileptic and chemotherapeutic drugs.

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Title: DNA sequence specificity for topoisomerase II poisoning by the quinoxaline anticancer drugs XK469 and CQS.

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Title: Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.

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Title: Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20030315

Title: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein.

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Title: [Chemosensitivity testing of oral and maxillofacial cancer with biopsy specimens].

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology20021101

Title: The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells.

Journal: Brain research. Molecular brain research20021015

Title: Platinum drugs in the treatment of non-small-cell lung cancer.

Journal: British journal of cancer20021007

Title: Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis.

Journal: Cancer20020901

Title: Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study (E1588).

Journal: Lung cancer (Amsterdam, Netherlands)20020901

Title: The case for the introduction of new chemotherapy agents in the treatment of advanced non small cell lung cancer in the wake of the findings of The National Institute of Clinical Excellence (NICE).

Journal: British journal of cancer20020827

Title: Application of pharmacokinetic modelling to the routine therapeutic drug monitoring of anticancer drugs.

Journal: Fundamental & clinical pharmacology20020801

Title: Quantitation of gene-specific DNA damage by competitive PCR.

Journal: Analytical biochemistry20020715

Title: Effect of the DNA topoisomerase II inhibitor VP-16 on illegitimate recombination in yeast chromosomes.

Journal: Gene20020529

Title: Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.

Journal: British journal of cancer20020506

Title: DNA damage and apoptosis in the mussel Mytilus galloprovincialis.

Journal: Marine environmental research20020401

Title: Evaluation of Podophyllum peltatum accessions for podophyllotoxin production.

Journal: Planta medica20020401

Title: DNA topoisomerase II is essential for preimplantation mouse development.

Journal: Molecular reproduction and development20020301

Title: [Chemotherapy combined with radiosurgery in the treatment of non-small cell lung cancer patients with brain metastasis].

Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer20020220

Title: Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin.

Journal: British journal of cancer20020201

Title: No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study.

Journal: Journal of pediatric hematology/oncology20020201

Title: In vitro thermo- and thermochemo-sensitivity of retinoblastoma cells from surgical specimens.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group20020101

Title: Toxoplasmic encephalitis in a non-HIV patient with follicular lymphoma.

Journal: International journal of hematology20020101

Title: BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells.

Journal: Journal of neuro-oncology20020101

Title: Assessment of drug activity and proliferation ex vivo for prediction of outcome in aggressive non-Hodgkin's lymphomas.

Journal: Acta oncologica (Stockholm, Sweden)20020101

Title: Active, but not inactive, human centromeres display topoisomerase II activity in vivo.

Journal: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology20020101

Title: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

Journal: The Journal of biological chemistry20011207

Title: Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.

Journal: International journal of clinical pharmacology and therapeutics20011201

Title: Consolidation therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of cytosine arabinoside, epipodophyllotoxins and cyclophosphamide.

Journal: Cancer treatment reviews20011201

Title: 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes.

Journal: The Journal of biological chemistry20011102

Title: Primary breast lymphoma: a report of 20 cases.

Journal: British journal of haematology20011101

Title: [Palliative irradiation combined with chemotherapy for lung cancer with brain metastasis].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology]20011101

Title: Diva/Boo is a negative regulator of cell death in human glioma cells.

Journal: FEBS letters20010907

Title: Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells.

Journal: British journal of haematology20010901

Title: Aryltetralin lignans: chemistry, pharmacology and biotransformations.

Journal: Current medicinal chemistry20010901

Title: Chemotherapy as treatment of primary and recurrent small cell lung cancer.

Journal: Lung cancer (Amsterdam, Netherlands)20010901

Title: Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells.

Journal: Biochemical pharmacology20010901

Title: Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS20010701

Title: Evaluation of teniposide (VM-26)-induced toxicity on mouse spermatogenesis by flow cytometry.

Journal: Toxicology20010621

Title: Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.

Journal: Biochemical pharmacology20010601

Title: Altered DNA-cleavage activity of topoisomerase II from WEHI-3B leukemia cells with specific resistance to ciprofloxacin.

Journal: Anti-cancer drugs20010601

Title: [Controversial treatment of brain metastases of small-cell lung cancer. Randomized comparison of chemotherapy alone and radiochemotherapy].

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]20010601

Title: Atp-bound topoisomerase ii as a target for antitumor drugs.

Journal: The Journal of biological chemistry20010511

Title: Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.

Journal: Lung cancer (Amsterdam, Netherlands)20010501

Title: Leukemias related to treatment with DNA topoisomerase II inhibitors.

Journal: Medical and pediatric oncology20010501

Title: Superiority of high-dose platinum (cisplatin and carboplatin) compared to carboplatin alone in combination chemotherapy for small-cell lung carcinoma: a prospective randomised trial of 280 consecutive patients.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010501

Title: APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis.

Journal: Cell death and differentiation20010401

Title: [Hypercalcemia due to adult T-cell lymphoma in a man from Surinam].

Journal: Nederlands tijdschrift voor geneeskunde20010224

Title: Caspase-dependent chemotherapy-induced death of glioma cells requires mitochondrial cytochrome c release.

Journal: Biochemical and biophysical research communications20010223

Title: Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death.

Journal: Cancer research20010201

Title: Cost-Effectiveness of interferon alfa-2b added to chemotherapy for high-tumor-burden follicular non-Hodgkin's lymphoma.

Journal: Leukemia & lymphoma20010201

Title: Standard chemotherapy with or without high-dose chemotherapy for aggressive non-Hodgkin's lymphoma: randomized phase III EORTC study.

Journal: Journal of the National Cancer Institute20010103

Title: ICE bioassay. Isolating in vivo complexes of enzyme to DNA.

Journal: Methods in molecular biology (Clifton, N.J.)20010101

Title: Concomitant cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy plus highly active antiretroviral therapy in patients with human immunodeficiency virus-related, non-Hodgkin lymphoma.

Journal: Cancer20010101

Title: Lung cancer: therapeutic options for stage IV and recurrent NSCLC.

Journal: Cancer treatment and research20010101

Title: Impact of intravesical chemotherapy on recurrence rate of recurrent superficial transitional cell carcinoma of the bladder: results of a meta-analysis.

Journal: Anticancer research20010101

Title: Effectiveness of interferon-alfa and mid-cycle chemotherapy added to an anthracycline-based regimen in the treatment of aggressive non-Hodgkin's lymphoma.

Journal: Leukemia & lymphoma20010101

Title: Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line.

Journal: Breast cancer research : BCR20010101

Title: Appearance of aberrant mitosis in murine leukemia cells upon combined treatment with low concentrations of cisplatin and teniposide.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20010101

Title: Controversies in the management of brain metastases: the role of chemotherapy.

Journal: Forum (Genoa, Italy)20010101

Title: Paclitaxel: a pharmacoeconomic review of its use in non-small cell lung cancer.

Journal: PharmacoEconomics20010101

Title: Induction of apoptosis by dexrazoxane (ICRF-187) through caspases in the absence of c-jun expression and c-Jun NH2-terminal kinase 1 (JNK1) activation in VM-26-resistant CEM cells.

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Title: Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method.

Journal: FEMS microbiology letters19990915

Title: Discovery of podophyllotoxins.

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Title: Double knockout of the MRP gene leads to increased drug sensitivity in vitro.

Journal: Cancer research19961201

Title: O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

Journal: Molecular pharmacology19940201

Title: Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.

Journal: Antimicrobial agents and chemotherapy19930701

Title: Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.

Journal: Toxicology letters19930401

Title: Inhibitors of human immunodeficiency virus integrase.

Journal: Proceedings of the National Academy of Sciences of the United States of America19930315

Title: Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

Journal: Biochemistry19891003

Title: Involvement of von Willebrand factor in thrombosis following asparaginase-prednisone-vincristine therapy for leukemia.

Journal: American journal of hematology19870701

Title: Vincristine neurotoxicity enhanced in combination chemotherapy including both teniposide and vincristine.

Journal: Cancer treatment reports19860401

Title: Combined VM-26 and cytosine arabinoside in treatment of refractory childhood lymphocytic leukemia.

Journal: Cancer19800315

Title: 4'-demethyl-epipodophyllotoxin-beta-D-thenylidene glucoside (VM-26)--a brief review.

Journal: European journal of cancer19730701

Title: Attia SM, et al. Molecular cytogenetic evaluation of the aneugenic effects of teniposide in somatic and germinal cells of male mice. Mutagenesis. 2012 Jan;27(1):31-9.

Title: Li J, et al. Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma. World J Surg Oncol. 2006 Jul 6;4:41.

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