[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn26
[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn27
[1]Patent:WO2006/32908,2006,A1.Locationinpatent:Page/Pagecolumn20-21
[1]JournalofMedicinalChemistry,2020,vol.63,p.2877-2893
[1]JournalofMedicinalChemistry,2020,vol.63,p.2877-2893
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Title: The Risk of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia in Hodgkin Lymphoma has Substantially Decreased in the ABVD Era Abolishing Mechlorethamine and Procarbazine and Limiting Volumes and Doses of Radiotherapy.
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Title: 4-Des-oxy-4β-(4-methoxy-carbonyl-1,2,3-triazol-1-yl)podophyllotoxin dichloro-methane solvate.
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Title: Retinoblastoma in children older than 5 years of age.
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Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20031101
Title: [Concomitant whole brain radiotherapy and FUDR+VM-26+DDP chemotherapy in brain metastasis of non-small cell lung cancer: a report of short term efficacy].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20031020
Title: Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031001
Title: P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Journal: Brain pathology (Zurich, Switzerland) 20031001
Title: Extraocular retinoblastoma: a 13-year experience.
Journal: Cancer 20030915
Title: Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030901
Title: Effect of Aplidin in acute lymphoblastic leukaemia cells.
Journal: British journal of cancer 20030818
Title: Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide.
Journal: Biochemical pharmacology 20030801
Title: Interactions between antiepileptic and chemotherapeutic drugs.
Journal: The Lancet. Neurology 20030701
Title: DNA sequence specificity for topoisomerase II poisoning by the quinoxaline anticancer drugs XK469 and CQS.
Journal: Molecular pharmacology 20030601
Title: Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Journal: Journal of medicinal chemistry 20030522
Title: [Treatment of malignant non-Hodgkin's lymphoma. Economic impact of rituximab (Mabthera) versus conventional chemotherapy].
Journal: Annales de medecine interne 20030501
Title: Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.
Journal: Bioorganic & medicinal chemistry 20030417
Title: Disseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030415
Title: Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315
Title: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein.
Journal: Cancer research 20030315
Title: Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia.
Journal: British journal of cancer 20030310
Title: Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme.
Journal: British journal of cancer 20030224
Title: Feasibility of combination chemotherapy with cisplatin and etoposide for haemodialysis patients with lung cancer.
Journal: British journal of cancer 20030113
Title: Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia.
Journal: Leukemia research 20030101
Title: Recent advances in traditional plant drugs and orchids.
Journal: Acta pharmacologica Sinica 20030101
Title: Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments.
Journal: Cancer investigation 20030101
Title: Enhanced production of podophyllotoxin by Podophyllum hexandrum using in situ cell retention bioreactor.
Journal: Biotechnology progress 20030101
Title: Successful paternity with microassisted fertilization after total body irradiation-based conditioning for autologous bone marrow transplantation.
Journal: The hematology journal : the official journal of the European Haematology Association 20030101
Title: Chemotherapy induced gastrointestinal toxicity in rats: involvement of mitochondrial DNA, gastrointestinal permeability and cyclooxygenase -2.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20030101
Title: [Teniposide and cisplatin compared with etoposide and cisplatin for treatment of small cell lung cancer].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20021201
Title: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6).
Journal: Cancer research 20021101
Title: [Chemosensitivity testing of oral and maxillofacial cancer with biopsy specimens].
Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20021101
Title: The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells.
Journal: Brain research. Molecular brain research 20021015
Title: Platinum drugs in the treatment of non-small-cell lung cancer.
Journal: British journal of cancer 20021007
Title: Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis.
Journal: Cancer 20020901
Title: Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study (E1588).
Journal: Lung cancer (Amsterdam, Netherlands) 20020901
Title: The case for the introduction of new chemotherapy agents in the treatment of advanced non small cell lung cancer in the wake of the findings of The National Institute of Clinical Excellence (NICE).
Journal: British journal of cancer 20020827
Title: Application of pharmacokinetic modelling to the routine therapeutic drug monitoring of anticancer drugs.
Journal: Fundamental & clinical pharmacology 20020801
Title: Quantitation of gene-specific DNA damage by competitive PCR.
Journal: Analytical biochemistry 20020715
Title: Effect of the DNA topoisomerase II inhibitor VP-16 on illegitimate recombination in yeast chromosomes.
Journal: Gene 20020529
Title: Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.
Journal: British journal of cancer 20020506
Title: DNA damage and apoptosis in the mussel Mytilus galloprovincialis.
Journal: Marine environmental research 20020401
Title: Evaluation of Podophyllum peltatum accessions for podophyllotoxin production.
Journal: Planta medica 20020401
Title: DNA topoisomerase II is essential for preimplantation mouse development.
Journal: Molecular reproduction and development 20020301
Title: [Chemotherapy combined with radiosurgery in the treatment of non-small cell lung cancer patients with brain metastasis].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20020220
Title: Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin.
Journal: British journal of cancer 20020201
Title: No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study.
Journal: Journal of pediatric hematology/oncology 20020201
Title: In vitro thermo- and thermochemo-sensitivity of retinoblastoma cells from surgical specimens.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101
Title: Toxoplasmic encephalitis in a non-HIV patient with follicular lymphoma.
Journal: International journal of hematology 20020101
Title: BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells.
Journal: Journal of neuro-oncology 20020101
Title: Assessment of drug activity and proliferation ex vivo for prediction of outcome in aggressive non-Hodgkin's lymphomas.
Journal: Acta oncologica (Stockholm, Sweden) 20020101
Title: Active, but not inactive, human centromeres display topoisomerase II activity in vivo.
Journal: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 20020101
Title: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).
Journal: The Journal of biological chemistry 20011207
Title: Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.
Journal: International journal of clinical pharmacology and therapeutics 20011201
Title: Consolidation therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of cytosine arabinoside, epipodophyllotoxins and cyclophosphamide.
Journal: Cancer treatment reviews 20011201
Title: 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes.
Journal: The Journal of biological chemistry 20011102
Title: Primary breast lymphoma: a report of 20 cases.
Journal: British journal of haematology 20011101
Title: [Palliative irradiation combined with chemotherapy for lung cancer with brain metastasis].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20011101
Title: Diva/Boo is a negative regulator of cell death in human glioma cells.
Journal: FEBS letters 20010907
Title: Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells.
Journal: British journal of haematology 20010901
Title: Aryltetralin lignans: chemistry, pharmacology and biotransformations.
Journal: Current medicinal chemistry 20010901
Title: Chemotherapy as treatment of primary and recurrent small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20010901
Title: Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells.
Journal: Biochemical pharmacology 20010901
Title: Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry.
Journal: Journal of mass spectrometry : JMS 20010701
Title: Evaluation of teniposide (VM-26)-induced toxicity on mouse spermatogenesis by flow cytometry.
Journal: Toxicology 20010621
Title: Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Journal: Biochemical pharmacology 20010601
Title: Altered DNA-cleavage activity of topoisomerase II from WEHI-3B leukemia cells with specific resistance to ciprofloxacin.
Journal: Anti-cancer drugs 20010601
Title: [Controversial treatment of brain metastases of small-cell lung cancer. Randomized comparison of chemotherapy alone and radiochemotherapy].
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20010601
Title: Atp-bound topoisomerase ii as a target for antitumor drugs.
Journal: The Journal of biological chemistry 20010511
Title: Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20010501
Title: Leukemias related to treatment with DNA topoisomerase II inhibitors.
Journal: Medical and pediatric oncology 20010501
Title: Superiority of high-dose platinum (cisplatin and carboplatin) compared to carboplatin alone in combination chemotherapy for small-cell lung carcinoma: a prospective randomised trial of 280 consecutive patients.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010501
Title: APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis.
Journal: Cell death and differentiation 20010401
Title: [Hypercalcemia due to adult T-cell lymphoma in a man from Surinam].
Journal: Nederlands tijdschrift voor geneeskunde 20010224
Title: Caspase-dependent chemotherapy-induced death of glioma cells requires mitochondrial cytochrome c release.
Journal: Biochemical and biophysical research communications 20010223
Title: Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death.
Journal: Cancer research 20010201
Title: Cost-Effectiveness of interferon alfa-2b added to chemotherapy for high-tumor-burden follicular non-Hodgkin's lymphoma.
Journal: Leukemia & lymphoma 20010201
Title: Standard chemotherapy with or without high-dose chemotherapy for aggressive non-Hodgkin's lymphoma: randomized phase III EORTC study.
Journal: Journal of the National Cancer Institute 20010103
Title: ICE bioassay. Isolating in vivo complexes of enzyme to DNA.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: Concomitant cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy plus highly active antiretroviral therapy in patients with human immunodeficiency virus-related, non-Hodgkin lymphoma.
Journal: Cancer 20010101
Title: Lung cancer: therapeutic options for stage IV and recurrent NSCLC.
Journal: Cancer treatment and research 20010101
Title: Impact of intravesical chemotherapy on recurrence rate of recurrent superficial transitional cell carcinoma of the bladder: results of a meta-analysis.
Journal: Anticancer research 20010101
Title: Effectiveness of interferon-alfa and mid-cycle chemotherapy added to an anthracycline-based regimen in the treatment of aggressive non-Hodgkin's lymphoma.
Journal: Leukemia & lymphoma 20010101
Title: Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line.
Journal: Breast cancer research : BCR 20010101
Title: Appearance of aberrant mitosis in murine leukemia cells upon combined treatment with low concentrations of cisplatin and teniposide.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101
Title: Controversies in the management of brain metastases: the role of chemotherapy.
Journal: Forum (Genoa, Italy) 20010101
Title: Paclitaxel: a pharmacoeconomic review of its use in non-small cell lung cancer.
Journal: PharmacoEconomics 20010101
Title: Induction of apoptosis by dexrazoxane (ICRF-187) through caspases in the absence of c-jun expression and c-Jun NH2-terminal kinase 1 (JNK1) activation in VM-26-resistant CEM cells.
Journal: Biochemical pharmacology 19991015
Title: Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method.
Journal: FEMS microbiology letters 19990915
Title: Discovery of podophyllotoxins.
Journal: Biochimie 19980301
Title: Double knockout of the MRP gene leads to increased drug sensitivity in vitro.
Journal: Cancer research 19961201
Title: O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.
Journal: Molecular pharmacology 19940201
Title: Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.
Journal: Antimicrobial agents and chemotherapy 19930701
Title: Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
Journal: Toxicology letters 19930401
Title: Inhibitors of human immunodeficiency virus integrase.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930315
Title: Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.
Journal: Biochemistry 19891003
Title: Involvement of von Willebrand factor in thrombosis following asparaginase-prednisone-vincristine therapy for leukemia.
Journal: American journal of hematology 19870701
Title: Vincristine neurotoxicity enhanced in combination chemotherapy including both teniposide and vincristine.
Journal: Cancer treatment reports 19860401
Title: Combined VM-26 and cytosine arabinoside in treatment of refractory childhood lymphocytic leukemia.
Journal: Cancer 19800315
Title: 4'-demethyl-epipodophyllotoxin-beta-D-thenylidene glucoside (VM-26)--a brief review.
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