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Home Thiazoles 300352-96-9
300352-96-9,MFCD10565926
Catalog No.:AA00BJVQ

300352-96-9 | 3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE

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10mg
98%
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$303.00   $212.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BJVQ
Chemical Name:
3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE
CAS Number:
300352-96-9
Molecular Formula:
C18H22N2O3S2
Molecular Weight:
378.5089
MDL Number:
MFCD10565926
SMILES:
CS(=O)(=O)C1=CC=C(C=C1)C(CC2CCCC2)C(=O)NC3=NC=CS3
Properties
Computed Properties
 
Complexity:
547  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.9  

Literature

Title: Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.

Journal: Journal of medicinal chemistry 20120823

Title: Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken.

Journal: General and comparative endocrinology 20101201

Title: Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).

Journal: Journal of medicinal chemistry 20100513

Title: Medicinal chemistry approaches for glucokinase activation to treat type 2 diabetes.

Journal: Current medicinal chemistry 20090101

Title: [Advances in the study of glucokinase and small molecule glucokinase activators].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060501

Title: Anglo-Swedish Medicinal Chemistry - second symposium.

Journal: IDrugs : the investigational drugs journal 20050501

Title: Glucokinase-activating ureas.

Journal: Bioorganic & medicinal chemistry letters 20050301

Title: Allosteric activators of glucokinase: potential role in diabetes therapy.

Journal: Science (New York, N.Y.) 20030718

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SDS
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Tags:300352-96-9 Molecular Formula|300352-96-9 MDL|300352-96-9 SMILES|300352-96-9 3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE