[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US6465493,2002,B1
[2]Callahan,JamesF.;Burgess,JoelleL.;Fornwald,JamesA.;Gaster,LaramieM.;Harling,JohnD.;Harrington,FrankP.;Heer,Jag;Kwon,Chet;Lehr,Ruth;Mathur;Olson,BarbaraA.;Weinstock,Joseph;Laping,NicholasJ.[JournalofMedicinalChemistry,2002,vol.45,#5,p.999-1001]
[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US6465493,2002,B1
[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US6465493,2002,B1
[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US6465493,2002,B1
Title: MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis.
Journal: Archives of toxicology 20180901
Title: The role of TGFβ receptor 1-smad3 signaling in regulating the osteoclastic mode affected by fluoride.
Journal: Toxicology 20180115
Title: Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Journal: Archives of toxicology 20180101
Title: Inhibition of the transforming growth factor-β/SMAD cascade mitigates the anti-neurogenic effects of the carbamate pesticide carbofuran.
Journal: The Journal of biological chemistry 20171124
Title: Substance P promotes hepatic stellate cell proliferation and activation via the TGF-β1/Smad-3 signaling pathway.
Journal: Toxicology and applied pharmacology 20170815
Title: Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests.
Journal: Archives of toxicology 20170101
Title: Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion.
Journal: Toxicology 20160729
Title: Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells.
Journal: PloS one 20160101
Title: Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts.
Journal: The Journal of biological chemistry 20150403
Title: TGF-β1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-β1/Smad pathway.
Journal: Toxicology and applied pharmacology 20141015
Title: A high-throughput screen for teratogens using human pluripotent stem cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: PDGF-D expression is down-regulated by TGFβ in fibroblasts.
Journal: PloS one 20140101
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Smad3 mediates cigarette smoke extract (CSE) induction of VEGF release by human fetal lung fibroblasts.
Journal: Toxicology letters 20130704
Title: Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.
Journal: Biochimica et biophysica acta 20130601
Title: The Akt-FoxO3a-manganese superoxide dismutase pathway is involved in the regulation of oxidative stress in diabetic nephropathy.
Journal: Experimental physiology 20130401
Title: Aberrant regulation of the BST2 (Tetherin) promoter enhances cell proliferation and apoptosis evasion in high grade breast cancer cells.
Journal: PloS one 20130101
Title: Lumican binds ALK5 to promote epithelium wound healing.
Journal: PloS one 20130101
Title: Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.
Journal: Journal of medicinal chemistry 20121126
Title: Heparan sulfate proteoglycans regulate responses to oocyte paracrine signals in ovarian follicle morphogenesis.
Journal: Endocrinology 20120901
Title: SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.
Journal: The Journal of biological chemistry 20120817
Title: The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
Journal: Journal of cellular physiology 20120801
Title: Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells.
Journal: Stem cells and development 20120720
Title: Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling.
Journal: Journal of cellular biochemistry 20120701
Title: Simultaneous suppression of TGF-β and ERK signaling contributes to the highly efficient and reproducible generation of mouse embryonic stem cells from previously considered refractory and non-permissive strains.
Journal: Stem cell reviews 20120601
Title: CREB coactivator CRTC2/TORC2 and its regulator calcineurin crucially mediate follicle-stimulating hormone and transforming growth factor β1 upregulation of steroidogenesis.
Journal: Journal of cellular physiology 20120601
Title: Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.
Journal: European journal of clinical pharmacology 20120601
Title: GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120601
Title: The regenerative capacity of the zebrafish heart is dependent on TGFβ signaling.
Journal: Development (Cambridge, England) 20120601
Title: Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.
Journal: Cellular signalling 20120501
Title: A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells.
Journal: Oncotarget 20120501
Title: Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells.
Journal: Cellular signalling 20120401
Title: Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules.
Journal: Cellular reprogramming 20120401
Title: Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
Journal: Molecular human reproduction 20120301
Title: Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition.
Journal: The Journal of pathology 20120301
Title: Inhibition of Mycobacterium tuberculosis-induced signalling by transforming growth factor-β in human mononuclear phagocytes.
Journal: Scandinavian journal of immunology 20120301
Title: Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation.
Journal: Stem cells (Dayton, Ohio) 20120301
Title: BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo.
Journal: Developmental biology 20120301
Title: Helicobacter infection induces podosome assembly in primary hepatocytes in vitro.
Journal: European journal of cell biology 20120301
Title: Structural basis for specificity of TGFβ family receptor small molecule inhibitors.
Journal: Cellular signalling 20120201
Title: Inhibin removes the inhibitory effects of activin on steroid enzyme expression and androgen production by normal ovarian thecal cells.
Journal: Journal of molecular endocrinology 20120201
Title: Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.
Journal: Cryobiology 20120201
Title: TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy.
Journal: Cell research 20120101
Title: Bone marrow osteoblast damage by chemotherapeutic agents.
Journal: PloS one 20120101
Title: Premature senescence and increased TGFβ signaling in the absence of Tgif1.
Journal: PloS one 20120101
Title: Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition.
Journal: International journal of radiation oncology, biology, physics 20111201
Title: Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells.
Journal: Angewandte Chemie (International ed. in English) 20111118
Title: Isolation and characterization of node/notochord-like cells from mouse embryonic stem cells.
Journal: Stem cells and development 20111101
Title: Treatment with IP-10 induces host-protective immune response by regulating the T regulatory cell functioning in Leishmania donovani-infected mice.
Journal: Medical microbiology and immunology 20111101
Title: Activin A stimulates mouse macrophages to express APRIL via the Smad3 and ERK/CREB pathways.
Journal: Immunology letters 20111030
Title: Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells.
Journal: Translational research : the journal of laboratory and clinical medicine 20111001
Title: Expression and functional role of CRIPTO-1 in cutaneous melanoma.
Journal: British journal of cancer 20110927
Title: Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells.
Journal: Diabetologia 20110901
Title: Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling.
Journal: Peptides 20110901
Title: The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system.
Journal: Breast cancer research and treatment 20110801
Title: Inhibition of Nodal suppresses angiogenesis and growth of human gliomas.
Journal: Journal of neuro-oncology 20110801
Title: Steroidogenic factor-1 is required for TGF-beta3-mediated 17beta-estradiol synthesis in mouse ovarian granulosa cells.
Journal: Endocrinology 20110801
Title: High-risk endometrial carcinoma profiling identifies TGF-β1 as a key factor in the initiation of tumor invasion.
Journal: Molecular cancer therapeutics 20110801
Title: A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells.
Journal: Cancer biology & therapy 20110801
Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Journal: European journal of medicinal chemistry 20110601
Title: Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.
Journal: Molecular reproduction and development 20110601
Title: Pharmacologic inhibition of ALK5 causes selective induction of terminal differentiation in mouse keratinocytes expressing oncogenic HRAS.
Journal: Molecular cancer research : MCR 20110601
Title: Novel population of embryonic secondary mesenchyme cells in the keyhole sand dollar Astriclypeus manni.
Journal: Development, growth & differentiation 20110601
Title: Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions.
Journal: PLoS genetics 20110601
Title: Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip.
Journal: Lab on a chip 20110521
Title: MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN.
Journal: Journal of cellular physiology 20110501
Title: Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis.
Journal: American journal of physiology. Lung cellular and molecular physiology 20110501
Title: TGF-β1 promotes motility and invasiveness of glioma cells through activation of ADAM17.
Journal: Oncology reports 20110501
Title: The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors.
Journal: Current cancer drug targets 20110501
Title: A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells.
Journal: Glycobiology 20110401
Title: Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier.
Journal: The Journal of pharmacology and experimental therapeutics 20110301
Title: Transforming growth factor β1 down-regulates Runx-2 and alkaline phosphatase activity of human dental pulp cells via ALK5/Smad2/3 signaling.
Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110301
Title: Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage.
Journal: Osteoarthritis and cartilage 20110201
Title: Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.
Journal: Journal of neuroscience research 20110201
Title: Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.
Journal: Stem cells (Dayton, Ohio) 20110201
Title: Involvement of Delta and Nodal signals in the specification process of five types of secondary mesenchyme cells in embryo of the sea urchin, Hemicentrotus pulcherrimus.
Journal: Development, growth & differentiation 20110101
Title: Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation.
Journal: Mechanisms of development 20110101
Title: The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.
Journal: PloS one 20110101
Title: TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Title: Evolution of the TGF-β signaling pathway and its potential role in the ctenophore, Mnemiopsis leidyi.
Journal: PloS one 20110101
Title: The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.
Journal: PloS one 20110101
Title: Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds.
Journal: PloS one 20110101
Title: Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression.
Journal: Carcinogenesis 20101201
Title: Albumin activates the canonical TGF receptor-smad signaling pathway but this is not required for activation of astrocytes.
Journal: Experimental neurology 20101201
Title: ALK5 inhibition blocks TGFß-induced CCN2 expression in gingival fibroblasts.
Journal: Journal of dental research 20101201
Title: Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity.
Journal: Oncology reports 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor.
Journal: Journal of cellular physiology 20101001
Title: Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-[beta] type I receptor.
Journal: Journal of cardiovascular pharmacology 20101001
Title: A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats.
Journal: American journal of physiology. Renal physiology 20101001
Title: Dynamic regulation of pituitary mRNAs for bone morphogenetic protein (BMP) 4, BMP receptors, and activin/inhibin subunits in the ewe during the estrous cycle and in cultured pituitary cells.
Journal: The Journal of endocrinology 20101001
Title: Transforming growth factor beta1 produced in autocrine/paracrine manner affects the morphology and function of mesothelial cells and promotes peritoneal carcinomatosis.
Journal: International journal of molecular medicine 20100901
Title: Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor.
Journal: The Journal of biological chemistry 20100827
Title: Activin A regulates trophoblast cell adhesive properties: implications for implantation failure in women with endometriosis-associated infertility.
Journal: Human reproduction (Oxford, England) 20100701
Title: Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells.
Journal: The Journal of biological chemistry 20100625
Title: Inhibition of transforming growth factor-beta signalling attenuates interleukin (IL)-18 plus IL-2-induced interstitial lung disease in mice.
Journal: Clinical and experimental immunology 20100601
Title: BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway.
Journal: Journal of cellular physiology 20100601
Title: Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.
Journal: Carcinogenesis 20100601
Title: Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/activin/nodal signaling using SB-431542.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601
Title: Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.
Journal: Molecular endocrinology (Baltimore, Md.) 20100601
Title: SB431542 treatment promotes the hypertrophy of skeletal muscle fibers but decreases specific force.
Journal: Muscle & nerve 20100501
Title: Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development.
Journal: Hepatology (Baltimore, Md.) 20100501
Title: Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100301
Title: Interleukin 11 and activin A synergise to regulate progesterone-induced but not cAMP-induced decidualization.
Journal: Journal of reproductive immunology 20100301
Title: Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cells.
Journal: European journal of cancer (Oxford, England : 1990) 20100301
Title: Fuzheng Huayu recipe and vitamin E reverse renal interstitial fibrosis through counteracting TGF-beta1-induced epithelial-to-mesenchymal transition.
Journal: Journal of ethnopharmacology 20100217
Title: Biphasic effects of selective inhibition of transforming growth factor beta1 activin receptor-like kinase on LPS-induced lung injury.
Journal: Shock (Augusta, Ga.) 20100201
Title: Pyrazolone based TGFbetaR1 kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100101
Title: Characterization of an lhx1a transgenic reporter in zebrafish.
Journal: The International journal of developmental biology 20100101
Title: TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5.
Journal: Journal of neuroinflammation 20100101
Title: Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics.
Journal: BMC musculoskeletal disorders 20100101
Title: TGF-β1 as possible link between loss of bone mineral density and chronic inflammation.
Journal: PloS one 20100101
Title: Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.
Journal: PloS one 20100101
Title: Differential effects of TGFbeta and vitreous on the transformation of retinal pigment epithelial cells.
Journal: Investigative ophthalmology & visual science 20091201
Title: Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection.
Journal: Memorias do Instituto Oswaldo Cruz 20091201
Title: A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.
Journal: Cell stem cell 20091106
Title: Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.
Journal: Cell stem cell 20091106
Title: Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells.
Journal: Stem cells (Dayton, Ohio) 20091101
Title: A chemical platform for improved induction of human iPSCs.
Journal: Nature methods 20091101
Title: [Impacts of PSK and TbetaR inhibitor on immune response in immunosuppressive status associated with cancer].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20091101
Title: Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha.
Journal: Immunology 20091101
Title: Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activation.
Journal: Stem cells (Dayton, Ohio) 20091001
Title: VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression.
Journal: Journal of cell science 20090915
Title: Desmoid cell motility is induced in vitro by rhEGF.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20090901
Title: Extra-ovarian expression and activity of growth differentiation factor 9.
Journal: The Journal of endocrinology 20090901
Title: Platelet-derived growth factor and transforming growth factor-beta modulate the expression of matrix metalloproteinases and migratory function of human airway smooth muscle cells.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090901
Title: Diabetes-relevant regulation of cultured blood outgrowth endothelial cells.
Journal: Microvascular research 20090901
Title: In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction.
Journal: Journal of cell science 20090901
Title: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures.
Journal: Cloning and stem cells 20090901
Title: Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5).
Journal: Bioorganic & medicinal chemistry letters 20090815
Title: Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090715
Title: Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.
Journal: American journal of physiology. Cell physiology 20090601
Title: Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue.
Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20090601
Title: Disruption of bidirectional oocyte-cumulus paracrine signaling during in vitro maturation reduces subsequent mouse oocyte developmental competence.
Journal: Biology of reproduction 20090501
Title: Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity.
Journal: Journal of cellular physiology 20090401
Title: p38-Mitogen-activated protein kinase stimulated steroidogenesis in granulosa cell-oocyte cocultures: role of bone morphogenetic proteins 2 and 4.
Journal: Endocrinology 20090401
Title: SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.
Journal: Investigative ophthalmology & visual science 20090401
Title: The core-aldehyde 9-oxononanoyl cholesterol increases the level of transforming growth factor beta1-specific receptors on promonocytic U937 cell membranes.
Journal: Aging cell 20090401
Title: Overexpression of manganese superoxide dismutase in human dermal fibroblasts enhances the contraction of free floating collagen lattice: implications for ageing and hyperplastic scar formation.
Journal: Archives of dermatological research 20090401
Title: TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation.
Journal: Oncogene 20090219
Title: Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta.
Journal: Neuroscience 20090218
Title: Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors.
Journal: European journal of medicinal chemistry 20090201
Title: TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.
Journal: The EMBO journal 20090121
Title: Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.
Journal: PloS one 20090101
Title: TGF-beta inhibits CYP17 transcription in H295R cells acting via activin receptor-like kinase 5.
Journal: Endocrine research 20090101
Title: Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
Journal: PloS one 20090101
Title: Neurokinin-A inhibits cell cycle activators in K562 cells and activates Smad 4 through a non-canonical pathway: a novel method in neural-hematopoietic axis.
Journal: Journal of neuroimmunology 20081115
Title: Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma.
Journal: Biochemical and biophysical research communications 20080919
Title: TGFbeta and SMADs talk to NANOG in human embryonic stem cells.
Journal: Cell stem cell 20080807
Title: NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs.
Journal: Cell stem cell 20080807
Title: TGF-beta inhibits prolactin-induced expression of beta-casein by a Smad3-dependent mechanism.
Journal: Journal of cellular biochemistry 20080801
Title: FK506 can activate transforming growth factor-beta signalling in vascular smooth muscle cells and promote proliferation.
Journal: Cardiovascular research 20080801
Title: Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.
Journal: The American journal of pathology 20080801
Title: Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta.
Journal: Carcinogenesis 20080501
Title: Improvement of the breaking strength of wound by combined treatment with recombinant human G-CSF, recombinant human M-CSF, and a TGF-beta1 receptor kinase inhibitor in rat skin.
Journal: Cancer science 20080501
Title: Transforming growth factor-beta1 regulates the fate of cultured spinal cord-derived neural progenitor cells.
Journal: Cell proliferation 20080401
Title: Transforming growth factor beta2 regulates growth and differentiation of pulp cells via ALK5/Smad2/3.
Journal: Journal of endodontics 20080401
Title: Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-beta type1 receptor kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20080315
Title: TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
Journal: Developmental biology 20080301
Title: Gamma-irradiation enhances RECK protein levels in Panc-1 pancreatic cancer cells.
Journal: Molecules and cells 20080227
Title: Activin induces long-lasting N-methyl-D-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1.
Journal: Neuroscience 20080219
Title: Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.
Journal: American journal of respiratory and critical care medicine 20080201
Title: Activin signaling limits the competence for retinal regeneration from the pigmented epithelium.
Journal: Mechanisms of development 20080101
Title: A quantitative analysis of kinase inhibitor selectivity.
Journal: Nature biotechnology 20080101
Title: TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI.
Journal: Journal of receptor and signal transduction research 20080101
Title: The type III TGF-beta receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation.
Journal: Carcinogenesis 20071201
Title: The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway.
Journal: Biochemical pharmacology 20071101
Title: Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta.
Journal: The Journal of pathology 20071101
Title: [Molecular mechanism of ciglitazone inhibiting the expression of extracellular matrix in human hepatic stellate cells].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20071101
Title: Involvement of signaling of VEGF and TGF-beta in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells.
Journal: Cell and tissue research 20070801
Title: In vitro analysis of transforming growth factor-beta1 inhibition in novel transgenic SBE-luciferase mice.
Journal: Annals of plastic surgery 20070801
Title: Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
Journal: The Biochemical journal 20070715
Title: Inhibition of human neutrophil degranulation by transforming growth factor-beta1.
Journal: Clinical and experimental immunology 20070701
Title: Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors.
Journal: Journal of medicinal chemistry 20070628
Title: Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.
Journal: Biology of reproduction 20070501
Title: ALK-5 mediates endogenous and TGF-beta1-induced expression of connective tissue growth factor in embryonic lung.
Journal: American journal of respiratory cell and molecular biology 20070501
Title: Pioglitazone induces apoptosis in human vascular smooth muscle cells from diabetic patients involving the transforming growth factor-beta/activin receptor-like kinase-4/5/7/Smad2 signaling pathway.
Journal: The Journal of pharmacology and experimental therapeutics 20070501
Title: Oocytes determine cumulus cell lineage in mouse ovarian follicles.
Journal: Journal of cell science 20070415
Title: Alpha-smooth muscle actin expression enhances cell traction force.
Journal: Cell motility and the cytoskeleton 20070401
Title: Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.
Journal: Experimental eye research 20070301
Title: Role of TGF-beta1 in vascular smooth muscle cell apoptosis induced by angiotensin II.
Journal: European journal of pharmacology 20070205
Title: Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.
Journal: Stem cells (Dayton, Ohio) 20070201
Title: Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells.
Journal: Journal of cell science 20070101
Title: Vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells.
Journal: Molecular vision 20070101
Title: Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish.
Journal: BMC developmental biology 20070101
Title: Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells.
Journal: The international journal of biochemistry & cell biology 20070101
Title: Transforming growth factor: beta signaling is essential for limb regeneration in axolotls.
Journal: PloS one 20070101
Title: PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
Journal: Biochemical and biophysical research communications 20061117
Title: ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cells.
Journal: Translational research : the journal of laboratory and clinical medicine 20061001
Title: Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte-fibroblast coculture contributes to keloid pathogenesis.
Journal: Journal of cellular physiology 20060801
Title: Identification of tocopherol-associated protein as an activin/TGF-beta-inducible gene in mast cells.
Journal: Biochimica et biophysica acta 20060801
Title: Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.
Journal: Developmental biology 20060715
Title: The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells.
Journal: Biochemical and biophysical research communications 20060714
Title: Activation and roles of ALK4/ALK7-mediated maternal TGFbeta signals in zebrafish embryo.
Journal: Biochemical and biophysical research communications 20060630
Title: In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats.
Journal: Transplantation 20060615
Title: Human NK cell IFN-gamma production is regulated by endogenous TGF-beta.
Journal: International immunopharmacology 20060601
Title: Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1.
Journal: International immunopharmacology 20060601
Title: Transforming growth factor-beta signaling enhances transdifferentiation of macrophages into smooth muscle-like cells.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20060401
Title: TGF-beta signaling in embryonic stem cell-derived endothelial cells.
Journal: Methods in molecular biology (Clifton, N.J.) 20060101
Title: Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions.
Journal: The Journal of pathology 20051001
Title: Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
Journal: Journal of cell science 20051001
Title: Antagonism of transforming growth factor-Beta signaling inhibits fibrosis-related genes.
Journal: Biotechnology letters 20051001
Title: ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability.
Journal: FEBS letters 20050718
Title: SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts.
Journal: Journal of dermatological science 20050701
Title: Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
Journal: The Journal of biological chemistry 20050610
Title: A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.
Journal: Neoplasia (New York, N.Y.) 20050501
Title: Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.
Journal: Brain research 20050321
Title: TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
Journal: Development (Cambridge, England) 20050301
Title: Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.
Journal: Arthritis and rheumatism 20041201
Title: A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation.
Journal: Cell death and differentiation 20041001
Title: SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.
Journal: Molecular cancer therapeutics 20040601
Title: SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
Journal: Molecular pharmacology 20040301
Title: Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells.
Journal: The EMBO journal 20040211
Title: SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
Journal: Cancer research 20031115
Title: Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes.
Journal: Kidney international 20020901
Title: Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
Journal: Molecular pharmacology 20020701
Title: SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Journal: Molecular pharmacology 20020701
Title: Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).
Journal: Journal of medicinal chemistry 20020227
Title: MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.
Journal: Molecular endocrinology (Baltimore, Md.)
Title: N. J. Laping, et al. Inhibition of Transforming Growth Factor (TGF)-β1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542.
Title: Inman GJ, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol, 2002, 62(1), 65-74.
Title: Halder SK, et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia, 2005, 7(5), 509-521.
Title: Matsuyama S, et al. SB-431542 inhibits transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res, 2003, 63(22), 7791-7798.
Title: Sato M, et al. Differential Proteome Analysis Identifies TGF-β-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model. PLoS One. 2015 May 18;10(5):e0126483.
Title: Ma J, et al. Growth differentiation factor 11 improves neurobehavioral recovery and stimulates angiogenesis in rats subjected to cerebral ischemia/reperfusion. Brain Res Bull. 2018 Feb 9;139:38-47
