+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 303162-79-0
303162-79-0,MFCD17012805
Catalog No.:AA002ZNA

303162-79-0 | Tak-715

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥99%
in stock  
$100.00   $70.00
- +
5mg
≥95%
in stock  
$116.00   $81.00
- +
10mg
≥95%
in stock  
$218.00   $152.00
- +
25mg
≥95%
in stock  
$509.00   $356.00
- +
50mg
≥95%
in stock  
$903.00   $632.00
- +
100mg
≥99%
in stock  
$1,295.00   $907.00
- +
500mg
98% by HPLC
in stock  
$5,515.00   $3,861.00
- +
1000mg
98% by HPLC
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002ZNA
Chemical Name:
Tak-715
CAS Number:
303162-79-0
Molecular Formula:
C24H21N3OS
Molecular Weight:
399.5080
MDL Number:
MFCD17012805
SMILES:
CCc1nc(c(s1)c1ccnc(c1)NC(=O)c1ccccc1)c1cccc(c1)C
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
538  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
5.6  

Downstream Synthesis Route
303162-79-0   
N-benzyl-N-4-2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl-pyridin-2-ylamine 

[1]JournalofMedicinalChemistry,2005,vol.48,p.5966-5979

[2]Patent:EP1180518,2002,A1.Locationinpatent:Example19

<i>N</i>-benzoyl-<i>N</i>-4-(2-ethyl-4-<i>m</i>-tolyl-thiazol-5-yl)-pyridin-2-yl-benzamide 
  303162-79-0 

[1]JournalofMedicinalChemistry,2005,vol.48,p.5966-5979

303162-79-0    74-88-4   
<i>N</i>-4-(2-ethyl-4-<i>m</i>-tolyl-thiazol-5-yl)-pyridin-2-yl-<i>N</i>-methyl-benzamide 

[1]JournalofMedicinalChemistry,2005,vol.48,p.5966-5979

[1]JournalofMedicinalChemistry,2005,vol.48,p.5966-5979

[1]JournalofMedicinalChemistry,2005,vol.48,p.5966-5979

Literature

Title: The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.

Journal: BMC neuroscience 20080101

Title: Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Journal: Journal of medicinal chemistry 20050922

Title: Miwatashi S, et al. Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N---ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl-2-pyridylbenzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J Med Chem, 2005, 48(19), 5966-5979.

Title: Verkaar F, et al. Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ. Chem Biol, 2011, 18(4), 485-494.

Title: Huiwen Ren, et al. Inhibition of α1-adrenoceptor reduces TGF-β1-induced epithelial-to-mesenchymal transition and attenuates UUO-induced renal fibrosis in mice. FASEB J. 2020 Nov;34(11):14892-14904.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 303162-79-0
303162-70-1

303162-70-1
Building Blocks
More >
Tags:303162-79-0 Molecular Formula|303162-79-0 MDL|303162-79-0 SMILES|303162-79-0 Tak-715