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304462-19-9,MFCD27992063
Catalog No.:AA00BEZG

304462-19-9 | Ave 0991

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$73.00   $51.00
- +
5mg
≥98%
in stock  
$309.00   $216.00
- +
10mg
≥98%
in stock  
$543.00   $380.00
- +
25mg
≥98%
in stock  
$993.00   $695.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BEZG
Chemical Name:
Ave 0991
CAS Number:
304462-19-9
Molecular Formula:
C29H32N4O5S2
Molecular Weight:
580.7182
MDL Number:
MFCD27992063
SMILES:
CCNC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(nc(c1C=O)OC)c1ccccc1)CC(C)C
Properties
Computed Properties
 
Complexity:
931  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
11  
XLogP3:
5.6  

Literature

Title: Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis.

Journal: British journal of pharmacology 20171101

Title: Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.

Journal: Blood 20150122

Title: Possible mechanism of the cardio-renal protective effects of AVE-0991, a non-peptide Mas-receptor agonist, in diabetic rats.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120901

Title: Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20120201

Title: The effect of AVE 0991, nebivolol and doxycycline on inflammatory mediators in an apoE-knockout mouse model of atherosclerosis.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats.

Journal: European journal of pharmacology 20080820

Title: Evidence for Mas-mediated bradykinin potentiation by the angiotensin-(1-7) nonpeptide mimic AVE 0991 in normotensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20071001

Title: Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991.

Journal: Life sciences 20070823

Title: Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20051001

Title: The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice.

Journal: Journal of cardiovascular pharmacology 20050901

Title: Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney.

Journal: Hypertension (Dallas, Tex. : 1979) 20041001

Title: 14C-labeled and large-scale synthesis of the angiotensin-(1-7)-receptor agonist AVE 0991 by cross-coupling reactions.

Journal: The Journal of organic chemistry 20030627

Title: Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension. 2002 Dec;40(6):847-52.

Title: Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6.

Title: Ferreira AJ, et al. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1113-9.

Title: Mo J, et al. AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2018 Sep 28;20:75-86.

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