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30651-60-6,MFCD00082807
Catalog No.:AA0030OX

30651-60-6 | 1-Amino piperazine

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0030OX
Chemical Name:
1-Amino piperazine
CAS Number:
30651-60-6
Molecular Formula:
C4H11N3
Molecular Weight:
101.1502
MDL Number:
MFCD00082807
SMILES:
NN1CCNCC1
Properties
Properties
 
BP:
163.1°C at 760 mmHg  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
48.9  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
XLogP3:
-1.1  

Literature

Title: Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101

Title: Evaluation of (99m)Tc(i)-tricarbonyl complexes of fluoroquinolones for targeting bacterial infection.

Journal: Metallomics : integrated biometal science 20121101

Title: Studies on the antimicrobial properties of N-acylated ciprofloxacins.

Journal: Bioorganic & medicinal chemistry letters 20121015

Title: Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.

Journal: Journal of medicinal chemistry 20120510

Title: Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.

Journal: Journal of medicinal chemistry 20120112

Title: Redox-controlled interconversion between trigonal prismatic and octahedral geometries in a monodithiolene tetracarbonyl complex of tungsten.

Journal: Inorganic chemistry 20120102

Title: Simultaneous determination of a novel diphenylpiperazine calcium channel blocker and its four metabolites in rat liver microsomes by liquid chromatography tandem mass spectrometry.

Journal: Pharmacology 20120101

Title: Piperazine-1,4-diium bis-(pyridine-2,6-dicarboxyl-ato-κO,N,O)cobaltate(II) tetra-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.

Journal: Journal of medicinal chemistry 20110414

Title: Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy.

Journal: Gut pathogens 20110101

Title: Tetra-imidazolium piperazinediium bis-(benzene-1,3,5-tricarboxyl-ate) dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20100915

Title: (3R,8aS)-3-Ethyl-perhydro-pyrrolo[1,2-a]pyrazine-1,4-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Redetermination of 2-[4-(2-hydroxy-ethyl)piperazin-1-ium-1-yl]ethanesul-fonate at 100 K.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Quinolones: action and resistance updated.

Journal: Current topics in medicinal chemistry 20090801

Title: Triprotic acid-base microequilibria and pharmacokinetic sequelae of cetirizine.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628

Title: Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Journal: Journal of medicinal chemistry 20090611

Title: Robust self-assembled monolayers of Ru(II) and Os(II) polypyridines on gold surfaces: exploring new potentials.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090602

Title: Direct intramolecular gas-phase transfer reactions during fragmentation of sildenafil and thiosildenafil analogs in electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20090301

Title: Isolation and identification of hydroxythiohomosildenafil in herbal dietary supplements sold as sexual performance enhancement products.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090201

Title: Anthracycline extravasation injuries: management with dexrazoxane.

Journal: Therapeutics and clinical risk management 20090101

Title: Novel fluorescent pH sensor based on coumarin with piperazine and imidazole substituents.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081201

Title: catena-Poly[[[(dimethyl-malonato-κO:O')(perchlorato-κO)copper(II)]-μ-bis-(3-pyridylmeth-yl)piperazinediium-κN:N] perchlorate dihydrate].

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: 8-Chloro-5-(4-phenethylpiperazin-1--yl)pyrido[2,3-b][1,5]benzoxazepine.

Journal: Acta crystallographica. Section E, Structure reports online 20081001

Title: Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements.

Journal: Journal of pharmaceutical and biomedical analysis 20080609

Title: Synthesis and biological characterization of novel 2-quinolinecarboxamide ligands of the peripheral benzodiazepine receptors bearing technetium-99m or rhenium.

Journal: Bioconjugate chemistry 20080601

Title: Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.

Journal: The AAPS journal 20080301

Title: Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070601

Title: 4-Amino derivatives of the Hsp90 inhibitor CCT018159.

Journal: Bioorganic & medicinal chemistry letters 20060501

Title: Solid-phase S-3CR generates N-substituted alpha-aminonitriles for the synthesis of alpha-phenyl-alpha-(1-piperazinyl) substituted amino acids.

Journal: Amino acids 20060501

Title: Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: Solution and solid state 13C NMR and X-ray studies of genistein complexes with amines. Potential biological function of the C-7, C-5, and C4'-OH groups.

Journal: Organic & biomolecular chemistry 20031021

Title: Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.

Journal: Journal of medicinal chemistry 20030410

Title: Functional group interactions of a 5-HT3R antagonist.

Journal: BMC biochemistry 20020101

Title: Application of LC-MS analysis to the characterisation of the in vitro and in vivo metabolite profiles of RGH-1756 in the rat.

Journal: Journal of pharmaceutical and biomedical analysis 20010301

Title: Synthesis and stereoselective kappa-receptor binding of methylated analogues of GR-89.696.

Journal: European journal of medicinal chemistry 20010201

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