Name: Name:Gw1100
Brand: AABLOCKS
SKU: AA00BE8D
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BE8D

Chemical Name: Gw1100

CAS Number: 306974-70-9

Molecular Formula: C27H25FN4O4S

Molecular Weight: 520.5752

MDL Number: MFCD09953714

SMILES: CCOc1ncc(cn1)Cc1cn(c2ccc(cc2)C(=O)OCC)c(nc1=O)SCc1ccc(cc1)F

Properties

Complexity: 832

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 37

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 11

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.7

Literature fold

Title: Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.

Journal: Molecular pharmacology20070401

Title: Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.

Journal: British journal of pharmacology20060701

Title: Stoddart LA, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-5Sthio)triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71(

Title: Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28.

Title: Manosalva C, et al. Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. PLoS One. 2015 Mar 19;10(3):e0119715.

Title: Nakamoto K, et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatorychronic pain. PLoS One. 2013 Dec 12;8(12):e81563.

306974-70-9 | Gw1100