Home Amines 30827-99-7
30827-99-7,MFCD00132962
Catalog No.:AA0031CL

30827-99-7 | 4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl

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1mg
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100mg
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250mg
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1g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0031CL
Chemical Name:
4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl
CAS Number:
30827-99-7
Molecular Formula:
C8H11ClFNO2S
Molecular Weight:
239.6948
MDL Number:
MFCD00132962
SMILES:
NCCc1ccc(cc1)S(=O)(=O)F.Cl
NSC Number:
727364
Properties
Properties
 
BP:
337°C at 760 mmHg  
Form:
Solid  
MP:
175-177 °C  
Solubility:
H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)  
Stability:
Moisture Sensitive  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
239  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Downstream Synthesis Route
(1'R,2'S,4'S,5'S)-4-{2-(hydroxycarbonyl)-1-pentynyl-6-methylaminopurin-9-yl}-1-(phosphato)-methyl-2-(phosphato)-bicyclo3.1.0hexane 
  5204-74-0    30827-99-7   
(x)C6H15N*C27H33FN6O11P2S 

[1]Patent:WO2009/152431,2009,A1.Locationinpatent:Page/Pagecolumn2;26;3/6

(1'R,2'S,4'S,5'S)-4-{2-5-(hydroxycarbonyl)-1-pentynyl-6-methylaminopurin-9-yl}-1-(phosphato)methyl-2-(phosphato)bicyclo3.1.0hexanetriethylammoniumsalt 
  5204-74-0    30827-99-7   
(1'R,2'S,4'S,5'S)-4-{2-6-(4-(fluorosulfonyl)phenethylamino)-6-oxohex-1-ynyl-6-methylaminopurin-9-yl}-1-(phosphato)methyl-2-(phosphato)bicyclo3.1.0hexanetriethylammoniumsalt 

[1]BioconjugateChemistry,2010,vol.21,p.1190-1205

2-(1-carboxymethyl-1<i>H</i>-quinolin-4-ylidenemethyl)-3-methyl-benzothiazol-3-ium 
  30827-99-7   
C28H25FN3O3S2(1+) 

[1]ChemicalCommunications,2015,vol.51,p.16197-16200

1-(2-amino-6-methylaminopyrimidin-yl)-piperidine-4-carboxylicacid 
  30827-99-7   
4-(2-((1-(2-amino-6-methylamino-pyrimidin-4-yl)-piperidine-4-carbonyl)amino)ethyl)benzenesulfonylfluoride 

[1]Patent:WO2016/128140,2016,A1.Locationinpatent:Page/Pagecolumn85

145013-05-4    30827-99-7   
4-(2-N',N''-diboc-guanidinoethyl)benzenesulfonylfluoride 

[1]Tetrahedron,2017,vol.73,p.4896-4900

Literature

Title: Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production.

Journal: Journal of biochemical and molecular toxicology 20170601

Title: Crystal structures of BapA complexes with β-lactam-derived inhibitors illustrate substrate specificity and enantioselectivity of β-aminopeptidases.

Journal: Chembiochem : a European journal of chemical biology 20120924

Title: Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.

Journal: Journal of medicinal chemistry 20120913

Title: Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction.

Journal: Free radical biology & medicine 20120901

Title: Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells.

Journal: Cancer science 20120601

Title: Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin.

Journal: The Journal of investigative dermatology 20120501

Title: Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay.

Journal: Clinical biochemistry 20120101

Title: A model to evaluate toxic factors influencing islets during collagenase digestion: the role of serine protease inhibitor in the protection of islets.

Journal: Cell transplantation 20120101

Title: Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.

Journal: PloS one 20120101

Title: Serine protease inhibitor, 4-(2-aminoethyl)-benzene sulfonyl fluoride, impairs IL-12-induced activation of pSTAT4β, NFκB, and select pro-inflammatory mediators from estrogen-treated mice.

Journal: Immunobiology 20111201

Title: Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro.

Journal: Contraception 20111201

Title: Development of a fluorescence resonance energy transfer peptide library technology for detection of protease contaminants in protein-based raw materials used in diagnostic assays.

Journal: Assay and drug development technologies 20111001

Title: Fluoride does not inhibit enamel protease activity.

Journal: Journal of dental research 20110401

Title: A practical guide for the stabilization of acylghrelin in human blood collections.

Journal: Clinical endocrinology 20110301

Title: Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization.

Journal: The Journal of biological chemistry 20110121

Title: A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa.

Journal: Veterinary research 20110101

Title: Peptidases of pinworms Syphacia muris and Passalurus ambiguus.

Journal: Experimental parasitology 20101001

Title: Comparative pharmacology of chemically distinct NADPH oxidase inhibitors.

Journal: British journal of pharmacology 20101001

Title: Serine proteases in histone deacetylase inhibitor-induced apoptosis.

Journal: Molecular cancer therapeutics 20100801

Title: Multiple protective functions of catalase against intercellular apoptosis-inducing ROS signaling of human tumor cells.

Journal: Biological chemistry 20100601

Title: Ontogeny of acylated ghrelin degradation in the rat.

Journal: Peptides 20100201

Title: Carboxymethyl-starch excipients for gastrointestinal stable oral protein formulations containing protease inhibitors.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

Title: Serine protease inhibitors suppress pancreatic endogenous proteases and modulate bacterial neutral proteases.

Journal: Islets 20100101

Title: HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients.

Journal: Biochimie 20090901

Title: Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.

Journal: Molecular and cellular endocrinology 20090813

Title: Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3.

Journal: Clinical and experimental immunology 20090501

Title: Shedding of gACE from residual body membrane of rat sperm.

Journal: Legal medicine (Tokyo, Japan) 20090401

Title: The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.

Journal: Acta biochimica et biophysica Sinica 20090301

Title: Comparison of trypsin inhibitors in preservation solution for islet isolation.

Journal: Cell transplantation 20090101

Title: Potential role of proprotein convertase SKI-1 in the mineralization of primary bone.

Journal: Cells, tissues, organs 20081201

Title: Modification of amyloid-beta(1-40) by a protease inhibitor creates risk of error in mass spectrometric quantitation of amyloid-beta(1-42).

Journal: Analytical biochemistry 20081115

Title: Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis.

Journal: Cell death and differentiation 20081101

Title: A method for quantifying melanosome transfer efficacy from melanocytes to keratinocytes in vitro.

Journal: Pigment cell & melanoma research 20081001

Title: Treatment of cells with n-alpha-tosyl-L-phenylalanine-chloromethyl ketone induces the proteolytic loss of STAT6 transcription factor.

Journal: Molecular immunology 20080901

Title: Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation.

Journal: Biochemistry 20080805

Title: Human laminin-332 degradation by Candida proteinases.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20080701

Title: GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.

Journal: Journal of cellular physiology 20080601

Title: Sulphur and nitrogen regulation of the protease-encoding ACP1 gene in the fungus Botrytis cinerea: correlation with a phospholipase D activity.

Journal: Microbiology (Reading, England) 20080501

Title: Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20080301

Title: Endogenous pancreatic protease activity and methods for impeding their function.

Journal: Transplantation proceedings 20080301

Title: Relationship between carbachol hyperstimulation-induced pancreatic intracellular trypsinogen and NF-kappa B activation in rats in vitro.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080201

Title: Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells.

Journal: International archives of allergy and immunology 20080101

Title: Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells.

Journal: Neurotoxicology 20071101

Title: Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis.

Journal: Journal of lipid research 20071101

Title: The role of fungal proteinases in pathophysiology of Stachybotrys chartarum.

Journal: Mycopathologia 20071001

Title: Association of specific proteolytic processing of bone sialoprotein and bone acidic glycoprotein-75 with mineralization within biomineralization foci.

Journal: The Journal of biological chemistry 20070907

Title: A single intrauterine injection of the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride reversibly inhibits embryo implantation in mice.

Journal: Contraception 20070901

Title: A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves.

Journal: Physiologia plantarum 20070901

Title: PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070701

Title: Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats.

Journal: Vascular pharmacology 20070601

Title: Endoplasmic reticulum stress-induced cell death mediated by the proteasome.

Journal: Cell death and differentiation 20070601

Title: A Bax/Bak-independent mechanism of cytochrome c release.

Journal: The Journal of biological chemistry 20070601

Title: Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease.

Journal: Cell research 20070201

Title: Adjustment of digestion enzyme composition improves islet isolation outcome from marginal grade human donor pancreata.

Journal: Cell and tissue banking 20070101

Title: Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2.

Journal: The international journal of biochemistry & cell biology 20070101

Title: Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells.

Journal: Mediators of inflammation 20070101

Title: Cleavage of misfolded nuclear receptor corepressor confers resistance to unfolded protein response-induced apoptosis.

Journal: Cancer research 20061015

Title: Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.

Journal: Gastroenterology 20061001

Title: Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases - a possible route for neutrophilic inflammation in chronic rhinosinusitis.

Journal: Clinical and experimental immunology 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The influence of fibrin polymerization and platelet-mediated contractile forces on citrated whole blood thromboelastography profile.

Journal: Thrombosis and haemostasis 20060501

Title: Platelet-activating factor-acetylhydrolase can monodeacylate and inactivate lipoteichoic acid.

Journal: Clinical and vaccine immunology : CVI 20060401

Title: Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization.

Journal: Oncogene 20060309

Title: Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

Journal: Journal of molecular biology 20060127

Title: Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox.

Journal: Free radical biology & medicine 20051115

Title: Shedding of the germinal angiotensin I-converting enzyme (gACE) involves a serine protease and is activated by epididymal fluid.

Journal: Biology of reproduction 20051101

Title: Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition.

Journal: Clinical and experimental immunology 20051101

Title: Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.

Journal: The Journal of biological chemistry 20050826

Title: Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids.

Journal: FEBS letters 20050815

Title: Coupling of size-exclusion chromatography to a continuous assay for subtilisin using a fluorescence resonance energy transfer peptide substrate: testing of two standard inhibitors.

Journal: Journal of chromatography. A 20050722

Title: Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes.

Journal: The Journal of biological chemistry 20050610

Title: The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease.

Journal: Biochemistry 20050308

Title: Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity.

Journal: European journal of pharmacology 20050307

Title: c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050201

Title: Pro- and anti-apoptotic effects of an inhibitor of chymotrypsin-like serine proteases.

Journal: Cell cycle (Georgetown, Tex.) 20041201

Title: Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma.

Journal: Haematologica 20041201

Title: The N-terminal extension of plant mitochondrial carrier proteins is removed by two-step processing: the first cleavage is by the mitochondrial processing peptidase.

Journal: Journal of molecular biology 20041119

Title: NADPH oxidase-dependent acid production in airway epithelial cells.

Journal: The Journal of biological chemistry 20040827

Title: Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1.

Journal: FEBS letters 20040827

Title: Antioxidants inhibit angiogenesis in vivo through down-regulation of nitric oxide synthase expression and activity.

Journal: Free radical research 20040501

Title: Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.

Journal: Biological chemistry 20031201

Title: Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.

Journal: Cell death and differentiation 20031001

Title: A serine protease is involved in the initiation of DNA damage-induced apoptosis.

Journal: Cell death and differentiation 20031001

Title: A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

Journal: The Journal of biological chemistry 20030815

Title: Reelin promotes peripheral synapse elimination and maturation.

Journal: Science (New York, N.Y.) 20030801

Title: Identification and partial characterization of two inducible gelatin-cleavage activities localized to the sea urchin extraembryonic matrix, the hyaline layer.

Journal: Biochimica et biophysica acta 20030407

Title: Characterization of a serine protease activity in Sarcocystis neurona merozoites.

Journal: The Journal of parasitology 20030401

Title: Evaluation of Pefabloc as a serine protease inhibitor during human-islet isolation.

Journal: Transplantation 20030227

Title: CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

Journal: Genes & development 20030201

Title: Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.

Journal: Molecular pharmacology 20030101

Title: Improved islet yields from Macaca nemestrina and marginal human pancreata after two-layer method preservation and endogenous trypsin inhibition.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030101

Title: Gibberellin-mediated proteasome-dependent degradation of the barley DELLA protein SLN1 repressor.

Journal: The Plant cell 20021201

Title: Effect of pefabloc on islet isolation from cold preserved rat pancreas.

Journal: Transplantation proceedings 20021101

Title: Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis.

Journal: Circulation research 20020614

Title: Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis.

Journal: The Journal of antimicrobial chemotherapy 20020501

Title: Oxidative stress increased respiration and generation of reactive oxygen species, resulting in ATP depletion, opening of mitochondrial permeability transition, and programmed cell death.

Journal: Plant physiology 20020401

Title: Phospholipase D contributes to transmural pressure control of prorenin processing in juxtaglomerular cell.

Journal: Hypertension (Dallas, Tex. : 1979) 20020201

Title: Inhibition of NADH/NADPH oxidase affects signal transduction by growth factor receptors in normal fibroblasts.

Journal: Archives of biochemistry and biophysics 20020115

Title: The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood.

Journal: Journal of endotoxin research 20020101

Title: Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules.

Journal: Digestion 20020101

Title: Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

Journal: FEBS letters 20010921

Title: Islet isolation: simple modifications can still yield big improvements.

Journal: Transplantation 20010827

Title: Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia.

Journal: Transplantation 20010827

Title: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis is dependent on activation of cysteine and serine proteases.

Journal: Cytokine 20010807

Title: Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib.

Journal: The Journal of biological chemistry 20010615

Title: Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid.

Journal: Oncogene 20010607

Title: Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini.

Journal: Gastroenterology 20010601

Title: Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line.

Journal: International journal of oncology 20010501

Title: Characterization of a protease responsible for truncated actin increase in neutrophils of patients with Behçet's disease.

Journal: Biological & pharmaceutical bulletin 20010201

Title: Studies on digestive proteases from midgut glands of a shrimp, Penaeus indicus, and a lobster, Nephrops norvegicus: Part 1. Proteolytic activity.

Journal: Applied biochemistry and biotechnology 20010201

Title: Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction.

Journal: Neuroscience 20010101

Title: A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells.

Journal: Experimental cell research 20000410

Title: Citron M, et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17(1):171-9

Title: Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60(3):328-36.

Title: Buitrago-Rey R, et al. Evaluation of two inhibitors of invasion: LY311727 -(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid and AEBSF -(2-aminoethyl)-benzenesulphonyl fluoride in acute murine toxoplasmosis. J Antimicrob Chemother.

Title: Jiang YH, et al. Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec;84(6):642-8.

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Tags:30827-99-7 Molecular Formula|30827-99-7 MDL|30827-99-7 SMILES|30827-99-7 4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl