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3093-35-4,MFCD00866006
Catalog No.:AA00I5Q0

3093-35-4 | (1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one

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Price(USD)
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10mg
≥98%
in stock  
$46.00   $32.00
- +
25mg
≥98%
in stock  
$100.00   $70.00
- +
50mg
≥98%
in stock  
$166.00   $116.00
- +
250mg
98%
in stock  
$304.00   $213.00
- +
5g
98%
in stock  
$1,974.00   $1,382.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I5Q0
Chemical Name:
(1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one
CAS Number:
3093-35-4
Molecular Formula:
C24H32ClFO5
Molecular Weight:
454.9593
MDL Number:
MFCD00866006
SMILES:
ClCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1CCC1=CC(=O)CC[C@]21C)F)(C)C
Properties
Computed Properties
 
Complexity:
887  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.6  

Literature

Title: Demonstration of the biphasic release of 0.1% halcinonide cream.

Journal: Journal of drugs in dermatology : JDD 20150101

Title: Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.

Journal: PloS one 20150101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies.

Journal: Contact dermatitis 20090501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Dead Sea extract sold under-the-counter.

Journal: The British journal of dermatology 20030701

Title: Tropical application of halcinonide cream reduces the severity and incidence of intraperitoneal adhesions in a rat model.

Journal: American journal of surgery 20020701

Title: Clobetasol propionate cream versus halcinonide cream in psoriasis.

Journal: International journal of dermatology 19860601

Title: A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis.

Journal: Cutis 19840801

Title: A controlled comparison of amcinonide cream 0.1 percent and halcinonide cream 0.1 percent in the treatment of eczematous dermatitis.

Journal: Cutis 19811001

Title: Pujos E, et al. Comparison of the analysis of corticosteroids using different techniques. Anal Bioanal Chem. 2005 Jan;381(1):244-54.

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Tags:3093-35-4 Molecular Formula|3093-35-4 MDL|3093-35-4 SMILES|3093-35-4 (1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one