Home Other Building Blocks 312752-85-5
312752-85-5,MFCD18633309
Catalog No.:AA01EOF7

312752-85-5 | YM758

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$144.00   $101.00
- +
5mg
95%
1 week  
$318.00   $223.00
- +
10mg
95%
1 week  
$483.00   $338.00
- +
25mg
95%
1 week  
$760.00   $532.00
- +
50mg
95%
1 week  
$1,051.00   $736.00
- +
100mg
95%
1 week  
$1,395.00   $976.00
- +
500mg
95%
1 week  
$2,743.00   $1,920.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOF7
Chemical Name:
YM758
CAS Number:
312752-85-5
Molecular Formula:
C26H32FN3O4
Molecular Weight:
469.5484
MDL Number:
MFCD18633309
SMILES:
COc1cc2CN(CCc2cc1OC)C(=O)[C@@H]1CCCN(C1)CCNC(=O)c1ccc(cc1)F
Properties

Literature

Title: Umehara K, et al. Hepatic uptake and excretion of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidinoethyl}-4-fluorobenzamide (YM758), a novel if channel inhibitor, in rats and humans. Drug Metab Dispos. 2008 Jun;36(6):1030-8.

Title: Umehara K, et al. Relationship between exposure of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidinoethyl}-4-fluorobenzamide (YM758), a "funny" if current channel inhibitor, and heart rate reduction in tachycardia-induced beagle dogs. Drug Metab Dispos. 2009 Jul;37(7):1427-33.

Title: Umehara K, et al. Investigation of long-term retention of unchanged (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidinoethyl}-4-fluorobenzamide, a novel "funny" If current channel inhibitor, and its metabolites in the eyeball and thoracic aorta of rats. Drug Metab Dispos. 2009 Nov;37(11):2137-44.

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