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Catalog No.:AA00I5T5

31282-04-9 | Hygromycin B solution from Biological Fermentation

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I5T5
Chemical Name:
Hygromycin B solution from Biological Fermentation
CAS Number:
31282-04-9
Molecular Formula:
C20H37N3O13
Molecular Weight:
527.5201
MDL Number:
MFCD06795480
SMILES:
OC[C@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](N)C[C@@H]([C@H]2O)NC)[C@@H]2[C@H]([C@H]1O)OC1(O2)O[C@H]([C@H](CO)N)[C@@H]([C@@H]([C@H]1O)O)O
UN Number:
3462
Properties
Computed Properties
 
Complexity:
756  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
15  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
11  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-6.6  

Literature

Title: Capreomycin and hygromycin B modulate the catalytic activity of the delta ribozyme in a manner that depends on the protonation and complexation with Cu2+ ions of these antibiotics.

Journal: Dalton transactions (Cambridge, England : 2003) 20120828

Title: Synthesis of the aminocyclitol units of (-)-hygromycin A and methoxyhygromycin from myo-inositol.

Journal: The Journal of organic chemistry 20120706

Title: Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei.

Journal: Molecular and biochemical parasitology 20120501

Title: Characterization of a compensatory mutant of Leishmania major that lacks ether lipids but exhibits normal growth, and G418 and hygromycin resistance.

Journal: Experimental parasitology 20120301

Title: Improved production of transgenic Dioscorea zingiberensis (Dioscoreaceae) by Agrobacterium tumefaciens-mediated transformation.

Journal: Genetics and molecular research : GMR 20120203

Title: Expression of rice thaumatin-like protein gene in transgenic banana plants enhances resistance to fusarium wilt.

Journal: Applied biochemistry and biotechnology 20120201

Title: Characterization and isolation of mutants producing increased amounts of isoamyl acetate derived from hygromycin B-resistant sake yeast.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Generation of astaxanthin mutants in Xanthophyllomyces dendrorhous using a double recombination method based on hygromycin resistance.

Journal: Methods in molecular biology (Clifton, N.J.) 20120101

Title: Efficient embryogenic suspension culturing and rapid transformation of a range of elite genotypes of sweet potato (Ipomoea batatas [L.] Lam.).

Journal: Plant science : an international journal of experimental plant biology 20111201

Title: Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe.

Journal: Cell cycle (Georgetown, Tex.) 20111015

Title: Plant-specific cation/H+ exchanger 17 and its homologs are endomembrane K+ transporters with roles in protein sorting.

Journal: The Journal of biological chemistry 20110930

Title: Drug-resistant cassettes for the efficient transformation of Candida guilliermondii wild-type strains.

Journal: FEMS yeast research 20110901

Title: A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae.

Journal: Eukaryotic cell 20110901

Title: A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.

Journal: Journal of molecular biology 20110715

Title: A novel light-dependent selection marker system in plants.

Journal: Plant biotechnology journal 20110401

Title: The characterization of transaldolase gene tal from Pichia stipitis and its heterologous expression in Fusarium oxysporum.

Journal: Molecular biology reports 20110301

Title: Highly efficient Agrobacterium-mediated transformation of banana cv. Rasthali (AAB) via sonication and vacuum infiltration.

Journal: Plant cell reports 20110301

Title: Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.

Journal: The Journal of biological chemistry 20110121

Title: The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: A GFP-based assay to quantify the impact of effectors on the ex planta development of the slowly growing barley pathogen Rhynchosporium commune.

Journal: Mycologia 20110101

Title: Agrobacterium-mediated genetic transformation of Coffea arabica (L.) is greatly enhanced by using established embryogenic callus cultures.

Journal: BMC plant biology 20110101

Title: Golgi apparatus-localized synaptotagmin 2 is required for unconventional secretion in Arabidopsis.

Journal: PloS one 20110101

Title: Transformation of Candida albicans with a synthetic hygromycin B resistance gene.

Journal: Yeast (Chichester, England) 20101201

Title: Coordination pattern, solution structure and DNA damage studies of the copper(II) complex with the unusual aminoglycoside antibiotic hygromycin B.

Journal: Dalton transactions (Cambridge, England : 2003) 20101107

Title: Towards β-globin gene-targeting with integrase-defective lentiviral vectors.

Journal: Biotechnology letters 20101101

Title: An embryogenic suspension cell culture system for Agrobacterium-mediated transformation of citrus.

Journal: Plant cell reports 20101101

Title: Disruption of gap junctions attenuates aminoglycoside-elicited renal tubular cell injury.

Journal: British journal of pharmacology 20100801

Title: Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system.

Journal: Journal of biotechnology 20100517

Title: ATP-binding cassette transporters as pitfalls in selection of transgenic cells.

Journal: Analytical biochemistry 20100415

Title: Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae.

Journal: Current genetics 20100401

Title: A Simplified and efficient method for transformation and gene tagging of Ustilago maydis using frozen cells.

Journal: Fungal genetics and biology : FG & B 20100401

Title: A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

Journal: The Journal of biological chemistry 20100305

Title: Arabidopsis sensitivity to protein synthesis inhibitors depends on 26S proteasome activity.

Journal: Plant cell reports 20100301

Title: Selection system and co-cultivation medium are important determinants of Agrobacterium-mediated transformation of sugarcane.

Journal: Plant cell reports 20100201

Title: Efficient repair of DNA double-strand breaks in malignant cells with structural instability.

Journal: Mutation research 20100105

Title: Agrobacterium-tumefaciens-mediated transformation of antifungal-lipopeptide-producing fungus Coleophoma empetri F-11899.

Journal: Current genetics 20091201

Title: Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388.

Journal: Chemistry & biology 20091125

Title: Investigating dominant selection markers for Coprinopsis cinerea: a carboxin resistance system and re-evaluation of hygromycin and phleomycin resistance vectors.

Journal: Current genetics 20091001

Title: GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20091001

Title: Auto-excision of selectable marker genes from transgenic tobacco via a stress inducible FLP/FRT site-specific recombination system.

Journal: Transgenic research 20090601

Title: Efficient gene disruption in the high-ploidy yeast Candida utilis using the Cre-loxP system.

Journal: Bioscience, biotechnology, and biochemistry 20090423

Title: The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin.

Journal: The Journal of biological chemistry 20090313

Title: PET imaging of T cells derived from umbilical cord blood.

Journal: Leukemia 20090301

Title: Genetic transformation and regeneration of Sesbania drummondii using cotyledonary nodes.

Journal: Plant cell reports 20090101

Title: Production of destomycin-A antibiotic by Streptomyces sp. using rice straw as fermented substrate.

Journal: Communications in agricultural and applied biological sciences 20090101

Title: Ribosome-small-subunit-dependent GTPase interacts with tRNA-binding sites on the ribosome.

Journal: Journal of molecular biology 20080829

Title: Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites.

Journal: The Journal of antibiotics 20080601

Title: The effect of co-cultivation and selection parameters on Agrobacterium-mediated transformation of Chinese soybean varieties.

Journal: Plant cell reports 20080301

Title: Usefulness of heterologous promoters in the Pseudozyma flocculosa gene expression system.

Journal: Bioscience, biotechnology, and biochemistry 20080201

Title: High efficiency poplar transformation.

Journal: Plant cell reports 20070901

Title: Agrobacterium tumefaciens-mediated transformation of Narcissus tazzeta var. chinensis.

Journal: Plant cell reports 20070901

Title: Prokaryotic expression and allergenicity assessment of hygromycin B phosphotransferase protein derived from genetically modified plants.

Journal: Journal of food science 20070901

Title: Chlamydomonas reinhardtii, a model system for functional validation of abiotic stress responsive genes.

Journal: Planta 20070801

Title: Transformation of taxol-producing endophytic fungi by restriction enzyme-mediated integration (REMI).

Journal: FEMS microbiology letters 20070801

Title: Crystallization and preliminary crystallographic analysis of hygromycin B phosphotransferase from Escherichia coli.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20070801

Title: Agrobacterium-mediated transformation of protocorm-like bodies in Cymbidium.

Journal: Plant cell reports 20070601

Title: Okadaic acid and trifluoperazine enhance Agrobacterium-mediated transformation in eastern white pine.

Journal: Plant cell reports 20070501

Title: Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.

Journal: Genetics 20070501

Title: [Protoplast transformation of Mortierella isabellina with hygromycin B resistance plasmid PD4].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20070501

Title: Elevated copy number of L-A virus in yeast mutant strains defective in ribosomal stalk.

Journal: Biochemical and biophysical research communications 20070406

Title: Plant native tryptophan synthase beta 1 gene is a non-antibiotic selection marker for plant transformation.

Journal: Planta 20070301

Title: Agrobacterium-mediated transformation (AMT) of Trichoderma reesei as an efficient tool for random insertional mutagenesis.

Journal: Applied microbiology and biotechnology 20070101

Title: Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.

Journal: Microbiology (Reading, England) 20061101

Title: Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking.

Journal: The Biochemical journal 20060815

Title: Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster.

Journal: Chemistry & biology 20060701

Title: Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.

Journal: Yeast (Chichester, England) 20060415

Title: Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA.

Journal: American journal of physiology. Renal physiology 20060301

Title: Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis.

Journal: The Biochemical journal 20060215

Title: [Study on factors influencing Agrobacterium-mediated transformation of Jatropha curcas].

Journal: Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20060201

Title: System of centromeric, episomal, and integrative vectors based on drug resistance markers for Saccharomyces cerevisiae.

Journal: BioTechniques 20060101

Title: Viroporin activity of SARS-CoV E protein.

Journal: Advances in experimental medicine and biology 20060101

Title: [Establishment of a stable and regulable 293 cell line expressing mycoplasma hyorhinis protein P37].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20051218

Title: Arabitol dehydrogenase as a selectable marker for rice.

Journal: Plant cell reports 20051201

Title: In vitro plant regeneration and genetic transformation of Dichanthium annulatum.

Journal: DNA and cell biology 20051101

Title: The Candida albicans vacuole is required for differentiation and efficient macrophage killing.

Journal: Eukaryotic cell 20051001

Title: ALBINO AND PALE GREEN 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana.

Journal: Plant & cell physiology 20050701

Title: Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence.

Journal: The Journal of biological chemistry 20050617

Title: Concise and enantioselective synthesis of the aminocyclitol core of hygromycin A.

Journal: Organic letters 20050331

Title: Stable genetic transformation of castor (Ricinus communis L.) via Agrobacterium tumefaciens-mediated gene transfer using embryo axes from mature seeds.

Journal: Plant cell reports 20050301

Title: [Effects of carnitine acetyltransferase gene knockout on long chain dicarboxylic acid production and metabolism of Candida tropicalis].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20050201

Title: A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport.

Journal: FEBS letters 20050117

Title: Human safety and genetically modified plants: a review of antibiotic resistance markers and future transformation selection technologies.

Journal: Journal of applied microbiology 20050101

Title: Overproduction of recombinant laccase using a homologous expression system in Coriolus versicolor.

Journal: Applied microbiology and biotechnology 20041201

Title: Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5p abolishes pre-rRNA processing at site A(2) without reducing the production of functional 40S subunits.

Journal: Eukaryotic cell 20041201

Title: [Construction and functional analysis of the pepB gene disruptant in Aspergillus niger].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20041201

Title: The yeast rRNA biosynthesis factor Ebp2p is also required for efficient nuclear division.

Journal: Yeast (Chichester, England) 20041030

Title: TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis.

Journal: The Journal of biological chemistry 20040716

Title: The yeast genes, ARL1 and CCZ1, interact to control membrane traffic and ion homeostasis.

Journal: Biochemical and biophysical research communications 20040702

Title: The Aspergillus nidulans amdS gene as a marker for the identification of multicopy T-DNA integration events in Agrobacterium-mediated transformation of Aspergillus awamori.

Journal: Current genetics 20040601

Title: After chitin docking, toxicity of Kluyveromyces lactis zymocin requires Saccharomyces cerevisiae plasma membrane H+-ATPase.

Journal: Cellular microbiology 20040601

Title: The mitochondrial ribosome of the protozoan Acanthamoeba castellanii is the target for macrolide antibiotics.

Journal: Molecular and biochemical parasitology 20040601

Title: Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy.

Journal: FEMS microbiology letters 20040601

Title: Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication.

Journal: The Journal of biological chemistry 20040507

Title: High-frequency transformation of Lobelia erinus L. by Agrobacterium-mediated gene transfer.

Journal: Plant cell reports 20040501

Title: Yeast ARL1 encodes a regulator of K+ influx.

Journal: Journal of cell science 20040501

Title: Iodide kinetics and dosimetry in vivo after transfer of the human sodium iodide symporter gene in rat thyroid carcinoma cells.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040501

Title: Cdk inhibitor ste9p/srw1p is involved in response to protein synthesis inhibition in fission yeast.

Journal: Biochemical and biophysical research communications 20040319

Title: Stable transformation of rice (Oryza sativa L.) via microprojectile bombardment of highly regenerative, green tissues derived from mature seed.

Journal: Plant cell reports 20040201

Title: Development of a non-lethal selection system by using the aadA marker gene for efficient recovery of transgenic rice (Oryza sativa L.).

Journal: Plant cell reports 20040201

Title: Development of highly regenerable callus lines and biolistic transformation of turf-type common bermudagrass [Cynodon dactylon (L.) Pers.].

Journal: Plant cell reports 20040101

Title: Agrobacterium-mediated transformation of polyploid cereals. The efficiency of selection and transgene expression in wheat.

Journal: Cellular & molecular biology letters 20040101

Title: Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.

Journal: International journal of oncology 20031001

Title: Sfp1 plays a key role in yeast ribosome biogenesis.

Journal: Eukaryotic cell 20031001

Title: Biosynthetic origin of hygromycin A.

Journal: Antimicrobial agents and chemotherapy 20030701

Title: [Optimization of T-dNA insertional mutagenesis and analysis of mutants of Magnaporthe grisea].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20030701

Title: Endogenous oxidoreductase expression is induced by aminoglycosides.

Journal: Archives of biochemistry and biophysics 20030601

Title: Isolation of the MNN9 gene of Yarrowia lipolytica (YlMNN9) and phenotype analysis of a mutant ylmnn9 Delta strain.

Journal: Yeast (Chichester, England) 20030501

Title: Binary transformation systems based on 'shooter' mutants of Agrobacterium tumefaciens: a simple, efficient and universal gene transfer technology that permits marker gene elimination.

Journal: Plant cell reports 20030401

Title: Transgene expression in broccoli (Brassica oleracea var. italica) clones propagated in vitro via leaf explants.

Journal: Plant cell reports 20030401

Title: Inhibition of DNA methylation and reactivation of silenced genes by zebularine.

Journal: Journal of the National Cancer Institute 20030305

Title: Efficient soybean transformation using hygromycin B selection in the cotyledonary-node method.

Journal: Planta 20030301

Title: A bleaching herbicidal activity of methoxyhygromycin (MHM) produced by an actinomycete strain Streptomyces sp. 8E-12.

Journal: Letters in applied microbiology 20030101

Title: Agrobacterium tumefaciens-mediated transformation of Festuca arundinacea (Schreb.) and Lolium multiflorum (Lam.).

Journal: Plant cell reports 20030101

Title: Agrobacterium tumefaciens integrates transfer DNA into single chromosomal sites of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast.

Journal: Eukaryotic cell 20021201

Title: Transgenics of an elite indica rice variety Pusa Basmati 1 harbouring the codA gene are highly tolerant to salt stress.

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 20021201

Title: Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae.

Journal: Current genetics 20021101

Title: Activation of delta-isoform of protein kinase C is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epithelia.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Genotoxicity associated with NO production in macrophages and co-cultured target cells.

Journal: Free radical biology & medicine 20020701

Title: Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.

Journal: The Prostate 20020601

Title: Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sites.

Journal: Molecular and biochemical parasitology 20020409

Title: A low-background inducible promoter system in Leishmania donovani.

Journal: Molecular and biochemical parasitology 20020201

Title: Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020104

Title: Integration of the gene for carboxin resistance does not impact the Ustilago maydis-maize interaction.

Journal: Current microbiology 20020101

Title: Stable genetic transformation of garlic plants using particle bombardment.

Journal: Cellular & molecular biology letters 20020101

Title: A transformation system for the biocontrol yeast, Candida oleophila, based on hygromycin B resistance.

Journal: Current genetics 20011201

Title: Novel and convenient methods for Candida tropicalis gene disruption using a mutated hygromycin B resistance gene.

Journal: Archives of microbiology 20011101

Title: Bicistronic expression of ecdysone-inducible receptors in mammalian cells.

Journal: BioTechniques 20010901

Title: Stable transformation of Pleurotus ostreatus to hygromycin B resistance using Lentinus edodes GPD expression signals.

Journal: Applied microbiology and biotechnology 20010901

Title: Molecular characterization of the actin-encoding gene and the use of its promoter for a dominant selection system in the methylotrophic yeast Hansenula polymorpha.

Journal: Applied microbiology and biotechnology 20010601

Title: Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus.

Journal: Bioscience, biotechnology, and biochemistry 20010501

Title: Generation of fusion genes carrying drug resistance, green fluorescent protein, and herpes simplex virus thymidine kinase genes in a single cistron.

Journal: Molecules and cells 20010430

Title: Asymmetric induction of conduritols via AAA reactions: synthesis of the aminocyclohexitol of hygromycin A.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010417

Title: Targeted gene deletion in Zygosaccharomyces bailii.

Journal: Yeast (Chichester, England) 20010130

Title: Transposition of autonomous and engineered impala transposons in Fusarium oxysporum and a related species.

Journal: Molecular & general genetics : MGG 20010101

Title: Transformation of Curvularia lunata IM 2901 with pAN7-1 influences selected physiological properties of the fungus.

Journal: Microbios 20010101

Title: Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays.

Journal: BMC genetics 20010101

Title: Modulation of translation termination mechanisms by cis- and trans-acting factors.

Journal: Cold Spring Harbor symposia on quantitative biology 20010101

Title: Inhibition of HIV type 1 production by hygromycin B.

Journal: AIDS research and human retroviruses 19980701

Title: Pardo JM, et al. Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism. J Gen Microbiol. 1985 Jun;131(6):1289-98.

Title: González A, et al. Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochim Biophys Acta. 1978 Dec 21;521(2):459-69.

Title: Pfister P, et al. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B. Antimicrob Agents Chemother. 2003 May;47(5):1496-502.

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Tags:31282-04-9 Molecular Formula|31282-04-9 MDL|31282-04-9 SMILES|31282-04-9 Hygromycin B solution from Biological Fermentation