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315183-21-2,MFCD03302441
Catalog No.:AA007J1L

315183-21-2 | Pac-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
5mg
98%
in stock  
$11.00   $8.00
- +
10mg
98%
in stock  
$15.00   $11.00
- +
50mg
98%
in stock  
$41.00   $29.00
- +
250mg
98%
in stock  
$119.00   $83.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007J1L
Chemical Name:
Pac-1
CAS Number:
315183-21-2
Molecular Formula:
C23H28N4O2
Molecular Weight:
392.4940
MDL Number:
MFCD03302441
SMILES:
C=CCc1cccc(c1O)/C=N/NC(=O)CN1CCN(CC1)Cc1ccccc1
NSC Number:
743444
Properties
Computed Properties
 
Complexity:
539  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
3.3  

Literature

Title: Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.

Journal: Nature chemical biology 20061001

Title: Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52.

Title: Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013 Dec 19;4:e968.

Title: Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.

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Tags:315183-21-2 Molecular Formula|315183-21-2 MDL|315183-21-2 SMILES|315183-21-2 Pac-1