Home Other Building Blocks 315703-52-7
315703-52-7,MFCD01044465
Catalog No.:AA00CHKK

315703-52-7 | JK184

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$9.00   $7.00
- +
5mg
95%
in stock  
$22.00   $15.00
- +
10mg
95%
in stock  
$32.00   $22.00
- +
25mg
95%
in stock  
$52.00   $36.00
- +
50mg
95%
in stock  
$86.00   $61.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CHKK
Chemical Name:
JK184
CAS Number:
315703-52-7
Molecular Formula:
C19H18N4OS
Molecular Weight:
350.4374
MDL Number:
MFCD01044465
SMILES:
CCOc1ccc(cc1)Nc1scc(n1)c1c(C)nc2n1cccc2
Properties
Properties
 
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
432  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
5.1  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

Journal: Angewandte Chemie (International ed. in English) 20090101

Title: A small-molecule antagonist of the hedgehog signaling pathway.

Journal: Chembiochem : a European journal of chemical biology 20071105

Title: Zhang N, et al. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. Nanoscale. 2015 Feb 14;7(6):2609-24.

Title: Colavito SA, et al. Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway. Breast Cancer Res. 2014 Sep 25;16(5):444.

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