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Home Other Building Blocks 315706-13-9
315706-13-9,MFCD02330020
Catalog No.:AA007IWH

315706-13-9 | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$63.00   $44.00
- +
5mg
≥95%
in stock  
$186.00   $130.00
- +
10mg
≥95%
in stock  
$306.00   $214.00
- +
25mg
≥95%
in stock  
$535.00   $374.00
- +
50mg
98%
in stock  
$874.00   $612.00
- +
100mg
98%
in stock  
$1,363.00   $954.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007IWH
Chemical Name:
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
CAS Number:
315706-13-9
Molecular Formula:
C18H16Cl2N4O4S
Molecular Weight:
455.3150
MDL Number:
MFCD02330020
SMILES:
OC(=O)C(=NNC1=NC(CS1)c1ccc(c(c1)Cl)Cl)Cc1ccccc1N(O)O
Properties
Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
6.1  

Literature

Title: Moerke NJ, et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26;128(2):257-67.

Title: Yi T, et al. 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget. 2014 Aug 15;5(15):6028-37.

Title: Wu M, et al. Anti-Cancer Effect of Cap-Translation Inhibitor 4EGI-1 in Human Glioma U87 Cells: Involvement of Mitochondrial Dysfunction and ER Stress. Cell Physiol Biochem. 2016;40(5):1013-1028. Epub 2016 Dec 12.

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Tags:315706-13-9 Molecular Formula|315706-13-9 MDL|315706-13-9 SMILES|315706-13-9 eIF4E/eIF4G Interaction Inhibitor, 4EGI-1