Home Amines 316173-57-6
316173-57-6,MFCD08703126
Catalog No.:AA00CHK4

316173-57-6 | 2-(Furan-2-yl)-7-(3-(4-methoxyphenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$33.00   $23.00
- +
10mg
98%
in stock  
$121.00   $85.00
- +
25mg
98%
in stock  
$192.00   $135.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00CHK4
Chemical Name:
2-(Furan-2-yl)-7-(3-(4-methoxyphenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
CAS Number:
316173-57-6
Molecular Formula:
C20H19N7O2
Molecular Weight:
389.4106
MDL Number:
MFCD08703126
SMILES:
COc1ccc(cc1)CCCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1
Properties
Computed Properties
 
Complexity:
547  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Todde;Moresco;Simonelli;Baraldi;Cacciari;Spalluto;Varani;Monopoli;Matarrese;Carpinelli;Magni;Kienle;Fazio[JournalofMedicinalChemistry,2000,vol.43,#23,p.4359-4362]

[1]Todde;Moresco;Simonelli;Baraldi;Cacciari;Spalluto;Varani;Monopoli;Matarrese;Carpinelli;Magni;Kienle;Fazio[JournalofMedicinalChemistry,2000,vol.43,#23,p.4359-4362]

[1]Todde;Moresco;Simonelli;Baraldi;Cacciari;Spalluto;Varani;Monopoli;Matarrese;Carpinelli;Magni;Kienle;Fazio[JournalofMedicinalChemistry,2000,vol.43,#23,p.4359-4362]

CASUnavailable 
  316173-57-6 

[1]Todde;Moresco;Simonelli;Baraldi;Cacciari;Spalluto;Varani;Monopoli;Matarrese;Carpinelli;Magni;Kienle;Fazio[JournalofMedicinalChemistry,2000,vol.43,#23,p.4359-4362]

CASUnavailable 
  316173-57-6 

[1]Todde;Moresco;Simonelli;Baraldi;Cacciari;Spalluto;Varani;Monopoli;Matarrese;Carpinelli;Magni;Kienle;Fazio[JournalofMedicinalChemistry,2000,vol.43,#23,p.4359-4362]

Literature

Title: The effect of A 2A receptor antagonist (SCH 442416) on the mRNA expression of Kir 2.1 and Kir 4.1 channels in rat retinal Müller cells under hypoxic conditions in vitro.

Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University 20130101

Title: Effect of A(2A) receptor antagonist (SCH 442416) on the mRNA expression of glutamate aspartate transporter and glutamine synthetase in rat retinal Müller cells under hypoxic conditions in vitro.

Journal: Experimental and therapeutic medicine 20120501

Title: In vitro effect of adenosine A2A receptor antagonist SCH 442416 on the expression of glutamine synthetase and glutamate aspartate transporter in rat retinal Müller cells at elevated hydrostatic pressure.

Journal: Oncology reports 20120301

Title: Functional changes in postsynaptic adenosine A(2A) receptors during early stages of a rat model of Huntington disease.

Journal: Experimental neurology 20111101

Title: Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson disease.

Journal: Neurology 20110524

Title: Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.

Journal: Bioorganic & medicinal chemistry letters 20110501

Title: Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.

Journal: Journal of medicinal chemistry 20110210

Title: Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum.

Journal: Neuropharmacology 20110101

Title: Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats.

Journal: European journal of pharmacology 20101215

Title: Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.

Journal: Bioorganic & medicinal chemistry 20101115

Title: Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.

Journal: Hypertension (Dallas, Tex. : 1979) 20100501

Title: Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100210

Title: An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers.

Journal: Clinical neuropharmacology 20100101

Title: The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.

Journal: British journal of pharmacology 20090701

Title: Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701

Title: Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: Adenosine receptors as therapeutic targets.

Journal: Nature reviews. Drug discovery 20060301

Title: In vivo imaging of adenosine A2A receptors in rat and primate brain using [11C]SCH442416.

Journal: European journal of nuclear medicine and molecular imaging 20050401

Title: Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.

Journal: Journal of medicinal chemistry 20001116

Title: Todde S, et, al. Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography. J Med Chem. 2000 Nov 16;43(23):4359-62.

Title: Moresco RM, et, al. In vivo imaging of adenosine A2A receptors in rat and primate brain using 1CSCH442416. Eur J Nucl Med Mol Imaging. 2005 Apr;32(4):405-13.

Title: Zheng J, et, al. Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3685-91.

Title: Maimon N, et, al. Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles. J Physiol. 2014 Jun 15;592(12):2575-90.

Title: Yu J, et, al. A 2A R Antagonists Upregulate Expression of GS and GLAST in Rat Hypoxia Model. Biomed Res Int. 2020 Oct 26;2020:2054293.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 316173-57-6
Tags:316173-57-6 Molecular Formula|316173-57-6 MDL|316173-57-6 SMILES|316173-57-6 2-(Furan-2-yl)-7-(3-(4-methoxyphenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine