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318250-11-2,MFCD27992162
Catalog No.:AA00CML1

318250-11-2 | Uridine5'-(pentahydrogen tetraphosphate), P'5'-ester with 2'-deoxycytidine, sodium salt (1

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1mg
4 weeks  
$2,375.00   $1,663.00
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2mg
4 weeks  
$3,536.00   $2,475.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CML1
Chemical Name:
Uridine5'-(pentahydrogen tetraphosphate), P'5'-ester with 2'-deoxycytidine, sodium salt (1
CAS Number:
318250-11-2
Molecular Formula:
C18H23N5Na4O21P4
Molecular Weight:
861.2502
MDL Number:
MFCD27992162
SMILES:
C1C(C(OC1N2C=CC(=NC2=O)N)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O.[Na+].[Na+].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
1560  
Covalently-Bonded Unit Count:
5  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
52  
Hydrogen Bond Acceptor Count:
21  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
14  

Literature

Title: Resource use, costs, and utility estimates for patients with cystic fibrosis with mild impairment in lung function: analysis of data collected alongside a 48-week multicenter clinical trial.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20120101

Title: A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells.

Journal: PloS one 20120101

Title: Exciting new clinical trials in cystic fibrosis: infants need not apply.

Journal: American journal of respiratory and critical care medicine 20110615

Title: Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.

Journal: Journal of medicinal chemistry 20110428

Title: Denufosol tetrasodium in patients with cystic fibrosis and normal to mildly impaired lung function.

Journal: American journal of respiratory and critical care medicine 20110301

Title: Hitting the target: new treatments for cystic fibrosis.

Journal: American journal of respiratory and critical care medicine 20101215

Title: Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively?

Journal: Pediatric pulmonology 20100201

Title: Emerging treatments in cystic fibrosis.

Journal: Drugs 20091001

Title: Update in cystic fibrosis 2008.

Journal: American journal of respiratory and critical care medicine 20090315

Title: Drug developers aim to treat cystic fibrosis through disease modification.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081215

Title: Denufosol: a review of studies with inhaled P2Y(2) agonists that led to Phase 3.

Journal: Pulmonary pharmacology & therapeutics 20080801

Title: Novel agents in cystic fibrosis.

Journal: Nature reviews. Drug discovery 20080701

Title: Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis.

Journal: Current opinion in pharmacology 20080601

Title: Experience using centralized spirometry in the phase 2 randomized, placebo-controlled, double-blind trial of denufosol in patients with mild to moderate cystic fibrosis.

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20080301

Title: Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0.

Journal: Investigative ophthalmology & visual science 20080201

Title: Phase 2 randomized safety and efficacy trial of nebulized denufosol tetrasodium in cystic fibrosis.

Journal: American journal of respiratory and critical care medicine 20070815

Title: Safety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis.

Journal: Pediatric pulmonology 20050401

Title: P2Y(2) receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice.

Journal: Investigative ophthalmology & visual science 20031001

Title: Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease.

Journal: Advanced drug delivery reviews 20021205

Title: The P2Y(2) receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat.

Journal: Investigative ophthalmology & visual science 20021101

Title: Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.

Journal: Investigative ophthalmology & visual science 20021101

Title: Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.

Journal: The Journal of pharmacology and experimental therapeutics 20020901

Title: Potency and duration of action of synthetic P2Y2 receptor agonists on Schirmer scores in rabbits.

Journal: Advances in experimental medicine and biology 20020101

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Tags:318250-11-2 Molecular Formula|318250-11-2 MDL|318250-11-2 SMILES|318250-11-2 Uridine5'-(pentahydrogen tetraphosphate), P'5'-ester with 2'-deoxycytidine, sodium salt (1