Title: Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
Journal: Toxicology and applied pharmacology 20170301
Title: Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20151101
Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: Spinal blockades of class I antiarrythmic drugs with bupivacaine by isobolographic analysis in rats.
Journal: Neuroscience letters 20121018
Title: Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.
Journal: JAMA 20121003
Title: Mexiletine for treatment of myotonia: a trial triumph for rare disease networks.
Journal: JAMA 20121003
Title: Primary erythromelalgia in a 12-year-old boy: positive response to sodium channel blockers despite negative SCN9A mutations.
Journal: Klinische Padiatrie 20120901
Title: Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642).
Journal: Basic & clinical pharmacology & toxicology 20120801
Title: Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Journal: The Journal of pharmacology and experimental therapeutics 20120701
Title: Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians.
Journal: The Journal of physiology 20120601
Title: Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.
Journal: Urology 20120601
Title: Enantioselective drug-protein interaction between mexiletine and plasma protein.
Journal: The Journal of pharmacy and pharmacology 20120601
Title: Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains.
Journal: Acta pharmacologica Sinica 20120501
Title: Asymmetric hydrolytic kinetic resolution with recyclable macrocyclic Co(III)-salen complexes: a practical strategy in the preparation of (R)-mexiletine and (S)-propranolol.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120423
Title: Wide QRS Tachycardia in a young patient.
Journal: Archives of internal medicine 20120409
Title: Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
Journal: Journal of medicinal chemistry 20120209
Title: Drug-induced hypersensitivity syndrome followed by persistent arthritis.
Journal: The Journal of dermatology 20120201
Title: Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: High-dose intravenous immunoglobulin monotherapy for drug-induced hypersensitivity syndrome.
Journal: Acta dermato-venereologica 20120101
Title: Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.
Journal: International heart journal 20120101
Title: Long QT syndrome with nocturnal cardiac events caused by a KCNH2 missense mutation (G604S).
Journal: Internal medicine (Tokyo, Japan) 20120101
Title: Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel.
Journal: PloS one 20120101
Title: Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.
Journal: Pacing and clinical electrophysiology : PACE 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Hemodialysis as an alternative treatment of mexiletine intoxication.
Journal: The American journal of emergency medicine 20111101
Title: Enantiomeric purity of chiral derivatizing reagents for enantioresolution.
Journal: Bioanalysis 20110901
Title: Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
Journal: Journal of medicinal chemistry 20110714
Title: Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Journal: Cardiovascular research 20110701
Title: Indirect enantioresolution of (R,S)-mexiletine by reversed-phase high-performance liquid chromatography via diastereomerization with [(S,S)-O,O'-di-p-toluoyl tartaric acid anhydride], (S)-naproxen and nine chiral reagents synthesized as variants of Marfey's reagent.
Journal: Biomedical chromatography : BMC 20110301
Title: High performance liquid chromatography enantioseparation of the novel designed mexiletine derivatives and its analogs.
Journal: Chirality 20110201
Title: Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.
Journal: Neurology 20110125
Title: Functional atrioventricular conduction block in an elderly patient with acquired long QT syndrome: elucidation of the mechanism of block.
Journal: Journal of electrocardiology 20110101
Title: Refractory erythromelalgia of the ears: response to mexiletine.
Journal: American journal of otolaryngology 20110101
Title: Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical.
Journal: Journal of pharmacological and toxicological methods 20110101
Title: Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection.
Journal: Journal of chromatographic science 20110101
Title: Reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-mexiletine prepared by microwave irradiation with four new chiral derivatizing reagents based on trichloro-s-triazine having amino acids as chiral auxiliaries and 10 others having amino acid amides.
Journal: Journal of chromatography. A 20101203
Title: Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study.
Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20100801
Title: Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
Journal: British journal of pharmacology 20100701
Title: Congenital long QT syndrome and 2:1 atrioventricular block: an optimistic outcome in the current era.
Journal: Heart rhythm 20100601
Title: Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity.
Journal: Archiv der Pharmazie 20100601
Title: Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.
Journal: Neurology 20100504
Title: Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords.
Journal: Neuroscience research 20100501
Title: Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.
Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20100501
Title: Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3.
Journal: Circulation research 20100430
Title: Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias.
Journal: Current pain and headache reports 20100401
Title: Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.
Journal: Chirality 20100301
Title: Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.
Journal: Journal of clinical pharmacology 20100301
Title: Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge.
Journal: Pacing and clinical electrophysiology : PACE 20100301
Title: Polymyositis presenting with cardiac manifestations: Report of two cases and review of the literature.
Journal: Clinical neurology and neurosurgery 20100201
Title: Fabrication and evaluation of chiral monolithic column modified by beta-cyclodextrin derivatives.
Journal: Talanta 20100115
Title: A case of mexiletine-induced hypersensitivity syndrome presenting as eosinophilic pneumonia.
Journal: Journal of Korean medical science 20100101
Title: Comparison of the effect of mexiletine and methylprednisolone on neural function and histopathological damage after transient spinal cord ischemia in rabbits.
Journal: Turkish neurosurgery 20100101
Title: Mexiletine reverses oxaliplatin-induced neuropathic pain in rats.
Journal: Journal of pharmacological sciences 20100101
Title: Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp.
Journal: Journal of pharmacological and toxicological methods 20100101
Title: Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation.
Journal: Journal of AOAC International 20100101
Title: Column-switching HPLC determination of mexiletine using tris(bipyridine)ruthenium(III) electrogenerated chemiluminescence and precolumn derivatization with divinylsulfone.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101
Title: Deracemization of mexiletine biocatalyzed by omega-transaminases.
Journal: Organic letters 20091105
Title: Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models.
Journal: Neurochemical research 20091001
Title: The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion.
Journal: Turkish neurosurgery 20091001
Title: Pharmacological characterization of standard analgesics on mechanical allodynia in streptozotocin-induced diabetic rats.
Journal: Neuropharmacology 20090901
Title: Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger's reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography.
Journal: Journal of chromatography. A 20090724
Title: Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
Journal: Chirality 20090701
Title: Mexiletine and lidocaine suppress the excitability of dorsal horn neurons.
Journal: Anesthesia and analgesia 20090701
Title: Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.
Journal: The Journal of veterinary medical science 20090701
Title: A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation.
Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090701
Title: Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
Journal: Toxicology and applied pharmacology 20090615
Title: Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current.
Journal: Journal of pharmacological sciences 20090601
Title: 5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.
Journal: Journal of medicinal chemistry 20090423
Title: 2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.
Journal: European journal of medicinal chemistry 20090401
Title: Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.
Journal: Experimental neurology 20090401
Title: Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report.
Journal: Headache 20090201
Title: Evaluation of pressor and visceromotor reflex responses to bladder distension in urethane anesthetized rats.
Journal: Neurourology and urodynamics 20090101
Title: Experience with oral mexiletine in primary erythromelalgia in children.
Journal: Annals of Saudi medicine 20090101
Title: Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution.
Journal: Journal of pharmaceutical and biomedical analysis 20081201
Title: Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel.
Journal: Circulation. Arrhythmia and electrophysiology 20081201
Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal: Journal of medicinal chemistry 20081113
Title: In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: compound effects of hERG pore region mutation and SCN5A N-terminus variant.
Journal: Heart rhythm 20081101
Title: A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.
Journal: The Journal of organic chemistry 20080905
Title: One from column A and one from column B: may I take your order?
Journal: Anesthesiology 20080801
Title: Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.
Journal: Anesthesiology 20080801
Title: Studies on somnolence in the daytime caused by drugs used for neuropathic pain.
Journal: Journal of pharmacological sciences 20080701
Title: Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
Journal: Bioorganic & medicinal chemistry 20080615
Title: Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
Journal: Bioorganic & medicinal chemistry 20080601
Title: [Central and peripheral mechanisms in antinociception: current and future perspectives].
Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20080601
Title: Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice.
Journal: Neuroscience 20080502
Title: Development and validation of HPLC method for the resolution of drug intermediates: DL-3-Phenyllactic acid, DL-O-acetyl-3-phenyllactic acid and (+/-)-mexiletine acetamide enantiomers.
Journal: Talanta 20080315
Title: Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success.
Journal: Journal of pain and symptom management 20080301
Title: Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome.
Journal: Heart rhythm 20080301
Title: Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Journal: Behavioural pharmacology 20080201
Title: Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.
Journal: Journal of medicinal chemistry 20080124
Title: Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.
Journal: Neurourology and urodynamics 20080101
Title: Selective and stability-indicating methods for the simultaneous determination of mexiletine hydrochloride and/or its related substance: 2,6-dimethylphenol.
Journal: Journal of AOAC International 20080101
Title: Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies.
Journal: Pain medicine (Malden, Mass.) 20080101
Title: Mexiletine for refractory chronic daily headache: a report of nine cases.
Journal: Headache 20080101
Title: [Determination of mexiletine in human blood by liquid chromatography-tandem mass spectrometry].
Journal: Fa yi xue za zhi 20071201
Title: Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
Title: The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury.
Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001
Title: Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients.
Journal: Circulation 20070904
Title: Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers.
Journal: Anesthesiology 20070901
Title: Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070701
Title: Burning mouth syndrome: will better understanding yield better management?
Journal: Pain practice : the official journal of World Institute of Pain 20070601
Title: Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
Journal: British journal of neurosurgery 20070601
Title: A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20070515
Title: Ventricular ectopy during REM sleep: implications for nocturnal sudden cardiac death.
Journal: Nature clinical practice. Cardiovascular medicine 20070501
Title: A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.
Journal: Journal of cardiovascular electrophysiology 20070401
Title: The cutaneous analgesic effect of class I antiarrhythmic drugs.
Journal: Anesthesia and analgesia 20070401
Title: Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301
Title: S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode.
Journal: Analytical and bioanalytical chemistry 20070301
Title: Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy.
Journal: Current pain and headache reports 20070201
Title: Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.
Journal: Biochemical and biophysical research communications 20070126
Title: Simultaneous separation of 14 antiarrhythmic drugs and determination of mexiletine and flecainide by capillary zone electrophoresis.
Journal: Journal of AOAC International 20070101
Title: The effect of intravenously administered mexiletine on tinnitus - a pilot study.
Journal: International journal of audiology 20061201
Title: The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage.
Journal: Neurological research 20061201
Title: Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population.
Journal: Biological & pharmaceutical bulletin 20061101
Title: Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine.
Journal: American journal of physiology. Heart and circulatory physiology 20061001
Title: Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.
Journal: British journal of pharmacology 20061001
Title: Acetazolamide acts directly on the human skeletal muscle chloride channel.
Journal: Muscle & nerve 20060901
Title: Evaluation of patients with paramyotonia at 23Na MR imaging during cold-induced weakness.
Journal: Radiology 20060801
Title: Successful parental use of an automated external defibrillator for an infant with long-QT syndrome.
Journal: Pediatrics 20060801
Title: Systemic lidocaine or mexiletine for neuropathic pain.
Journal: American family physician 20060701
Title: Myotonia congenita--a cause of muscle weakness and stiffness.
Journal: Nature clinical practice. Neurology 20060701
Title: Neuroprotective effect of mexiletine in the central nervous system of diabetic rats.
Journal: Molecular and cellular biochemistry 20060601
Title: Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Journal: European journal of pharmacology 20060501
Title: Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae.
Journal: Biochemical pharmacology 20060428
Title: Effect of mexiletine on vincristine-induced painful neuropathy in mice.
Journal: European journal of pharmacology 20060424
Title: Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Journal: Neuroscience letters 20060313
Title: [An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman].
Journal: Deutsche medizinische Wochenschrift (1946) 20060303
Title: Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation.
Journal: European journal of pharmacology 20060217
Title: A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.
Journal: The Journal of clinical investigation 20060201
Title: Influence of mexiletine on action potential discharge and conduction in nodose Adelta afferent neurons innervating guinea pig isolated trachea.
Journal: Pulmonary pharmacology & therapeutics 20060101
Title: Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation.
Journal: Journal of veterinary internal medicine 20060101
Title: Effects of mexiletine on electrical field stimulation-induced contractile responses in the ipsilateral and contralateral vasa deferentia after unilateral testicular torsion/detorsion.
Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20060101
Title: Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7.
Journal: Dermatology (Basel, Switzerland) 20060101
Title: Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells.
Journal: European journal of pharmacology 20051228
Title: The effect of stationary phase on lipophilicity determination of beta-blockers using reverse-phase chromatographic systems.
Journal: Biomedical chromatography : BMC 20051201
Title: Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis.
Journal: Anesthesia and analgesia 20051201
Title: Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice.
Journal: Journal of cardiovascular electrophysiology 20051201
Title: Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
Journal: Pain 20051101
Title: Systemic administration of local anesthetic agents to relieve neuropathic pain.
Journal: The Cochrane database of systematic reviews 20051019
Title: Double-blind, placebo-controlled pilot study of mexiletine for acute mania or hypomania.
Journal: Journal of clinical psychopharmacology 20051001
Title: Drug therapy in Brugada syndrome.
Journal: Current drug targets. Cardiovascular & haematological disorders 20051001
Title: Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
Journal: Pain 20050901
Title: Prevention of ventricular extrasystole by mexiletine in patients with normal QT intervals is associated with a reduction of transmural dispersion of repolarization.
Journal: International journal of cardiology 20050803
Title: Mexiletine treatment-induced inhibition of caspase-3 activation and improvement of behavioral recovery after spinal cord injury.
Journal: Journal of neurosurgery. Spine 20050701
Title: [Symptomatic treatment of painful diabetic neuropathy].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20050601
Title: Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes: prediction of in vivo drug interactions.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050601
Title: Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model.
Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20050501
Title: Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment.
Journal: Pediatrics 20050401
Title: Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Journal: Bioorganic & medicinal chemistry letters 20050401
Title: Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.
Journal: The Journal of dermatology 20050401
Title: Preferred mexiletine block of human sodium channels with IVS4 mutations and its pH-dependence.
Journal: Pharmacogenetics and genomics 20050401
Title: Fiction: the Christmas card.
Journal: Neurology 20050308
Title: Systemic lidocaine and mexiletine for the treatment of a patient with total ulcerative colitis.
Journal: Gut 20050301
Title: Inhibitory effects of lidocaine and mexiletine on vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels and the role of kinases in the porcine coronary artery.
Journal: Anesthesiology 20050301
Title: A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.
Journal: Molecular pharmacology 20050201
Title: The effects of mexiletine on excitability properties of human median motor axons.
Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20050201
Title: Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Journal: Journal of cardiovascular pharmacology 20041201
Title: Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice.
Journal: Journal of pharmacological sciences 20041101
Title: [The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].
Journal: [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20041101
Title: A case of fulminant Type 1 diabetes associated with mexiletine hypersensitivity syndrome.
Journal: Diabetic medicine : a journal of the British Diabetic Association 20041001
Title: Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man.
Journal: Therapeutic drug monitoring 20041001
Title: Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20041001
Title: A case of primary erythromelalgia improved by mexiletine.
Journal: The British journal of dermatology 20040901
Title: Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
Journal: Molecular pharmacology 20040801
Title: New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.
Journal: Neuromuscular disorders : NMD 20040701
Title: Rate-dependent QRS prolongation during exercise testing associated with hyperkalemia.
Journal: Journal of electrocardiology 20040701
Title: Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine.
Journal: Acta neurochirurgica 20040601
Title: Antinociceptive effects of sodium channel-blocking agents on acute pain in mice.
Journal: Journal of pharmacological sciences 20040601
Title: Images in cardiovascular medicine. Life-threatening neonatal arrhythmia: successful treatment and confirmation of clinically suspected extreme long QT-syndrome-3.
Journal: Circulation 20040511
Title: Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Journal: Annals of nuclear medicine 20040501
Title: A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs.
Journal: Cardiovascular research 20040401
Title: Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors.
Journal: Biochemical pharmacology 20040301
Title: Frequent ventricular extrasystole treated by needling neiguan (PC 6) plus oral administration of mexiletine--a report of 30 cases.
Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20040301
Title: Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.
Journal: The Journal of physiology 20040201
Title: Stereospecific synthesis of 'para-hydroxymexiletine' and sodium channel blocking activity evaluation.
Journal: Chirality 20040201
Title: Systemic lidocaine in pain due to peripheral nerve injury and predictors of response.
Journal: Neurology 20040127
Title: Novel antiarrhythmic compounds with combined class IB and class III mode of action.
Journal: Current medicinal chemistry 20040101
Title: Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy.
Journal: Clinical and experimental pharmacology & physiology 20040101
Title: Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.
Journal: Receptors & channels 20040101
Title: Comparison of classical and derivative UV-spectrophotometric methods for the quantification of diltiazem and mexiletine.
Journal: Acta poloniae pharmaceutica 20040101
Title: Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.
Journal: Journal of medicinal chemistry 20031120
Title: Akt activation induced by an antioxidant compound during ischemia-reperfusion.
Journal: Free radical biology & medicine 20031101
Title: Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury.
Journal: Neurosurgical review 20031001
Title: Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus.
Journal: The Journal of pharmacy and pharmacology 20031001
Title: Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers.
Journal: European journal of clinical pharmacology 20030901
Title: Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.
Journal: European journal of pharmacology 20030822
Title: Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20030801
Title: Mexiletine carbonyloxy beta-D-glucuronide: a novel metabolite in human urine.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030801
Title: Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine.
Journal: Biological & pharmaceutical bulletin 20030601
Title: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
Journal: Brain : a journal of neurology 20030401
Title: Effect of mexiletine on long QT syndrome model.
Journal: Acta pharmacologica Sinica 20030401
Title: [Treatment of familial erythermalgia with the association of lidocaine and mexiletine].
Journal: Annales de dermatologie et de venereologie 20030401
Title: Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits.
Journal: European journal of pharmacology 20030328
Title: Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.
Journal: Cardiovascular research 20030315
Title: Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.
Journal: Anesthesia and analgesia 20030301
Title: Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20030301
Title: Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030301
Title: [HPLC-fluorescent spectrometric determination of serum mexiletine concentration after derivatization with fluram].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030301
Title: [Intractable hiccups treated with mexiletine hydrochloride].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20030210
Title: A case of a short-coupled variant of torsades de Pointes with electrical storm.
Journal: Pacing and clinical electrophysiology : PACE 20030201
Title: A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
Journal: European journal of pharmacology 20030105
Title: Storms of ventricular tachyarrhythmias associated with primary hyperparathyroidism in a patient with dilated cardiomyopathy.
Journal: International journal of cardiology 20030101
Title: Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030101
Title: The effect of commonly used drugs on angiogenesis.
Journal: Anticancer research 20030101
Title: The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats.
Journal: Neurotoxicity research 20030101
Title: Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.
Journal: Neurotoxicity research 20030101
Title: Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures.
Journal: Neurotoxicity research 20030101
Title: Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy.
Journal: Cardiology 20030101
Title: A patient with seizures and a positive drug screen: three wrongs don't make a right.
Journal: The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20030101
Title: Stable expression and characterization of human PN1 and PN3 sodium channels.
Journal: Receptors & channels 20030101
Title: Persistent pain management for improved quality of life.
Journal: Journal of the American Pharmacists Association : JAPhA 20030101
Title: [Differential diagnosis of idiopathic ventricular fibrillation].
Journal: Deutsche medizinische Wochenschrift (1946) 20021122
Title: The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
Journal: Anesthesia and analgesia 20021001
Title: [Diabetic neuropathy--concept, staging, diagnosis, treatment].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001
Title: Modification of the fenvalerate-induced nociceptive response in mice by diabetes.
Journal: Brain research 20020906
Title: Mexiletine on segmental hyperhidrosis.
Journal: Journal of neurology, neurosurgery, and psychiatry 20020901
Title: Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20020901
Title: Activation-recovery interval as a parameter to assess the intracardiac ventricular repolarization in patients with congenital long QT syndrome.
Journal: The American journal of cardiology 20020815
Title: Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.
Journal: Journal of medicinal chemistry 20020815
Title: Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers.
Journal: Journal of the American Veterinary Medical Association 20020815
Title: Pharmacological rescue of mutant ion channels.
Journal: Cardiovascular research 20020801
Title: A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.
Journal: Cardiovascular research 20020801
Title: Sodium channel-blocking agents are not of benefit to rats with kaolin-induced hydrocephalus.
Journal: Neurosurgery 20020801
Title: Effects of analgesics on delayed postherpetic pain in mice.
Journal: Anesthesiology 20020501
Title: Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.
Journal: Clinical pharmacology and therapeutics 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.
Journal: Brain research 20020405
Title: Cardioprotective effect of mexiletine in acute myocardial ischemia tudies in the rabbit closed chest ischemia mode.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20020401
Title: Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature.
Journal: Pacing and clinical electrophysiology : PACE 20020401
Title: Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol.
Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20020401
Title: Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients.
Journal: Journal of clinical pharmacology 20020301
Title: Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects.
Journal: Journal of neurophysiology 20020301
Title: Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel.
Journal: FEBS letters 20020227
Title: Electrical storms in an ICD-recipient with 429 delivered appropriate shocks: therapeutic management with antiarrhythmic drug combination.
Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20020201
Title: Evaluation of mexiletine clearance in a Japanese population.
Journal: The Annals of pharmacotherapy 20020201
Title: Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.
Journal: Acta neurochirurgica 20020201
Title: Rehabilitation of peripheral nerve injuries.
Journal: Physical medicine and rehabilitation clinics of North America 20020201
Title: [Lipomatosis dolorosa--a frequently overlooked disease picture].
Journal: Der Nervenarzt 20020201
Title: Mexiletine is effective on segmental hyperhidrosis: report of two cases.
Journal: Journal of neurology, neurosurgery, and psychiatry 20020101
Title: [Possibility of gene-specific treatment for hereditary arrhythmic diseases].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020101
Title: The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine.
Journal: Current medicinal chemistry 20020101
Title: Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20020101
Title: Schwartz-Jampel syndrome: report of one case.
Journal: Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi 20020101
Title: Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel.
Journal: The Journal of physiology 20011215
Title: Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats.
Journal: British journal of pharmacology 20011201
Title: Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.
Journal: Neurology 20011127
Title: Scavenger effect of experimental and clinically used cardiovascular drugs.
Journal: Journal of cardiovascular pharmacology 20011101
Title: Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011101
Title: Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.
Journal: Anesthesiology 20010901
Title: Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle.
Journal: European journal of pharmacology 20010810
Title: ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Journal: Journal of medicinal chemistry 20010719
Title: Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.
Journal: British journal of clinical pharmacology 20010701
Title: In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.
Journal: British journal of pharmacology 20010701
Title: Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.
Journal: Anesthesiology 20010701
Title: Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.
Journal: Japanese journal of pharmacology 20010701
Title: Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.
Journal: Japanese journal of pharmacology 20010501
Title: DDPH inhibited L-type calcium current and sodium current in single ventricular myocyte of guinea pig.
Journal: Acta pharmacologica Sinica 20010501
Title: The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.
Journal: Brain research 20010420
Title: Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation.
Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20010401
Title: Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats.
Journal: Clinical and experimental pharmacology & physiology 20010301
Title: Effect of fluvoxamine on the pharmacokinetics of mexiletine in healthy Japanese men.
Journal: Clinical pharmacology and therapeutics 20010301
Title: [Enantioseparation of twelve pharmaceutical racemates with high performance capillary electrophoresis using L-leucine as chiral selector].
Journal: Se pu = Chinese journal of chromatography 20010301
Title: Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.
Journal: Anesthesiology 20010101
Title: Regional block and mexiletine: the effect on pain after cancer breast surgery.
Journal: Regional anesthesia and pain medicine 20010101
Title: Acute exanthematous pustular drug eruption induced by mexiletine.
Journal: European journal of dermatology : EJD 20010101
Title: [Paramyotonia congenita].
Journal: Ryoikibetsu shokogun shirizu 20010101
Title: [Na channel myotonia].
Journal: Ryoikibetsu shokogun shirizu 20010101
Title: Effects of mexiletine on the canine cardiovascular system complicating cisapride overdose: potential utility of mexiletine for the treatment of drug-induced long QT syndrome.
Journal: Japanese journal of pharmacology 20000801
Title: Efficacy of oral mexiletine for neuropathic pain with allodynia: a double-blind, placebo-controlled, crossover study.
Journal: Regional anesthesia and pain medicine 20000101
Title: Effect of oral mexiletine on capsaicin-induced allodynia and hyperalgesia: a double-blind, placebo-controlled, crossover study.
Journal: Regional anesthesia and pain medicine 20000101
Title: Lack of stereoselectivity for the antiallodynic effect of mexiletine in spinally injured rats.
Journal: European journal of pain (London, England) 20000101
Title: Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice.
Journal: Methods and findings in experimental and clinical pharmacology 19990101
Title: Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction.
Journal: Pain 19971001
Title: Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed.
Journal: American heart journal 19940401
Title: Neurotoxicity of lidocaine combined with mexiletine.
Journal: Anesthesia and analgesia 19931201
Title: Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals.
Journal: European journal of pharmacology 19920121
Title: Mexiletine-associated left ventricular dysfunction: a case study.
Journal: Maryland medical journal (Baltimore, Md. : 1985) 19910601
Title: Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia.
Journal: The American journal of cardiology 19901115
Title: Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.
Journal: Cardiovascular research 19901101
Title: Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing.
Journal: The American journal of cardiology 19900215
Title: Differentiation and mechanisms of prevention and termination of verapamil-sensitive sustained ventricular tachycardia.
Journal: The American journal of cardiology 19891205
Title: Congestive heart failure induced by six of the newer antiarrhythmic drugs.
Journal: Journal of the American College of Cardiology 19891101
Title: Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts.
Journal: Journal of the American College of Cardiology 19890701
Title: Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents.
Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19890601
Title: General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Journal: Arzneimittel-Forschung 19881001
Title: Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias.
Journal: The American journal of cardiology 19871201
Title: [2 cases of lidocaine-resistant ventricular tachycardia treated with i.v. mexiletine during complicated acute myocardial infarct].
Journal: La Clinica terapeutica 19871130
Title: Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107.
Journal: Drugs under experimental and clinical research 19870101
Title: [Anti-arrhythmic efficacy of the amiodarone-mexiletine combination in the treatment of resistant complex ventricular arrhythmias].
Journal: Giornale italiano di cardiologia 19860501
Title: Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes.
Journal: Southern medical journal 19850201
Title: Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain.
Journal: Arzneimittel-Forschung 19850101
Title: International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group.
Journal: Journal of the American College of Cardiology 19841201
Title: Facilitation of ventricular tachyarrhythmia induction by isoproterenol.
Journal: The American journal of cardiology 19841001
Title: Mexiletine for recurring ventricular arrhythmias: assessment by long-term electrocardiographic recordings and sequential electrophysiologic studies.
Journal: American heart journal 19840901
Title: Hemodynamic effects of mexiletine.
Journal: American heart journal 19840501
Title: Mexiletine in refractory ventricular arrhythmias.
Journal: Clinical pharmacology and therapeutics 19831201
Title: Drug interactions with amiodarone.
Journal: American heart journal 19831001
Title: Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.
Journal: Japanese circulation journal 19830101
Title: [Sulfinpyrazone-associated renal failure (author's transl)].
Journal: Deutsche medizinische Wochenschrift (1946) 19820709
Title: [Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results].
Journal: Giornale italiano di cardiologia 19820101
Title: New drugs for treating cardiac arrhythmias.
Journal: Postgraduate medicine 19810101
Title: Torsades de pointes as a manifestation of mexiletine toxicity.
Journal: American heart journal 19801201
Title: Mexiletine in the treatment of ventricular arrhythmias.
Journal: Acta cardiologica. Supplementum 19800101
