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322-79-2,MFCD00866793
Catalog No.:AA007GWY

322-79-2 | Triflusal

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1mg
97%
in stock  
$7.00   $5.00
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5mg
97%
in stock  
$11.00   $8.00
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10mg
97%
in stock  
$14.00   $10.00
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50mg
97%
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$37.00   $26.00
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1g
98%(HPLC)
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$507.00   $355.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007GWY
Chemical Name:
Triflusal
CAS Number:
322-79-2
Molecular Formula:
C10H7F3O4
Molecular Weight:
248.1554
MDL Number:
MFCD00866793
SMILES:
CC(=O)Oc1cc(ccc1C(=O)O)C(F)(F)F
Properties
Computed Properties
 
Complexity:
313  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.1  

Literature

Title: Antiplatelet treatment in primary and secondary stroke prevention in women.

Journal: European journal of internal medicine 20121001

Title: Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120301

Title: Review of atrial fibrillation outcome trials of oral anticoagulant and antiplatelet agents.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301

Title: Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest 20120201

Title: Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

Journal: PLoS computational biology 20120201

Title: Effect of pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation.

Journal: International journal of clinical practice 20120101

Title: Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice.

Journal: Journal of neuroinflammation 20120101

Title: Aspirin prophylaxis for the prevention of thrombosis: expectations and limitations.

Journal: Thrombosis 20120101

Title: Preventing stroke in atrial fibrillation patients - clinical utility of oral anticoagulants.

Journal: Journal of blood medicine 20120101

Title: Recommendations for management of patients with carotid stenosis.

Journal: Stroke research and treatment 20120101

Title: A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.

Journal: Expert opinion on drug metabolism & toxicology 20111201

Title: Gastrointestinal safety of triflusal solution in healthy volunteers: a proof of concept endoscopic study.

Journal: European journal of clinical pharmacology 20110701

Title: Antiagregation and anticoagulation, relationship with upper gastrointestinal bleeding.

Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20110701

Title: Letter by Borja and Garcia-Rafanell regarding article, 'Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association'.

Journal: Stroke 20110601

Title: Two cases of h(2)-receptor antagonist hypersensitivity and cross-reactivity.

Journal: Allergy, asthma & immunology research 20110401

Title: Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties.

Journal: Cardiovascular diabetology 20110101

Title: Effect of the dual endothelin receptor antagonist bosentan on untreatable skin ulcers in a patient with diabetes: a case report.

Journal: Journal of medical case reports 20110101

Title: Antiplatelets in secondary stroke prevention.

Journal: Frontiers in neurology 20110101

Title: Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury.

Journal: TheScientificWorldJournal 20110101

Title: Optimal management of peripheral arterial disease for the non-specialist.

Journal: The Ulster medical journal 20110101

Title: Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke.

Journal: Brain research 20101217

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Bioactive polymeric systems with platelet antiaggregating activity for the coating of vascular devices.

Journal: Biomacromolecules 20101011

Title: Oral antiplatelet therapy in stroke prevention. Minireview.

Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20100901

Title: Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes.

Journal: Combinatorial chemistry & high throughput screening 20100801

Title: Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.

Journal: Neurobiology of disease 20100601

Title: Thinking outside the box about COX-1 in Alzheimer's disease.

Journal: Neurobiology of disease 20100601

Title: Update on antithrombotic therapy for stroke prevention in atrial fibrillation.

Journal: Current treatment options in cardiovascular medicine 20100601

Title: Thrombi of different pathologies: implications for diagnosis and treatment.

Journal: Current treatment options in cardiovascular medicine 20100601

Title: In vitro and in vivo performance of a dual drug-eluting stent (DDES).

Journal: Biomaterials 20100501

Title: Influence of antiplatelet pre-treatment on the risk of intracranial haemorrhage in acute ischaemic stroke after intravenous thrombolysis.

Journal: European journal of neurology 20100201

Title: Comparative bioavailability study of triflusal oral solution vs. triflusal capsules in healthy subjects. A single, randomized, two-way cross-over, open-label phase I study.

Journal: Arzneimittel-Forschung 20100101

Title: Study on QSTR of benzoic acid compounds with MCI.

Journal: International journal of molecular sciences 20100101

Title: Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis.

Journal: BMC medicine 20100101

Title: Presenilin/gamma-Secretase and Inflammation.

Journal: Frontiers in aging neuroscience 20100101

Title: Eicosanoids in the innate immune response: TLR and non-TLR routes.

Journal: Mediators of inflammation 20100101

Title: Prevention strategies for cardioembolic stroke: present and future perspectives.

Journal: The open neurology journal 20100101

Title: Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?

Journal: Frontiers in aging neuroscience 20100101

Title: Is there an association between low dose aspirin and anemia (without overt bleeding)? Narrative review.

Journal: BMC geriatrics 20100101

Title: Staging anti-inflammatory therapy in Alzheimer's disease.

Journal: Frontiers in aging neuroscience 20100101

Title: Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials.

Journal: Alzheimer's research & therapy 20100101

Title: Comparison of triple antiplatelet therapy including triflusal and conventional dual therapy in patients who underwent drug-eluting stent implantation.

Journal: International heart journal 20091101

Title: The short-term effect on restenosis and thrombosis of a cobalt-chromium stent eluting two drugs in a porcine coronary artery model.

Journal: Journal of interventional cardiology 20091001

Title: Long-term follow-up of atrial fibrillation patients in the NASPEAF study. Prospective evaluation of different antiplatelet treatments.

Journal: Revista espanola de cardiologia 20090901

Title: Neuroprotective effects of the anti-inflammatory compound triflusal on ischemia-like neurodegeneration in mouse hippocampal slice cultures occur independent of microglia.

Journal: Experimental neurology 20090701

Title: Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.

Journal: ChemMedChem 20090701

Title: Mechanism-based treatments for Alzheimer's disease.

Journal: Dialogues in clinical neuroscience 20090601

Title: Effect of age on stroke prevention therapy in patients with atrial fibrillation: the atrial fibrillation investigators.

Journal: Stroke 20090401

Title: [Resistance to triflusal or an insufficient dose?].

Journal: Revista de neurologia 20090401

Title: Triflusal: an old drug in modern antiplatelet therapy. Review of its action, use, safety and effectiveness.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20090101

Title: Triflusal and aspirin have different effects on inflammatory biomarkers measured in patients with acute ischemic stroke.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20090101

Title: Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.

Journal: Journal of thrombosis and haemostasis : JTH 20080801

Title: Salicylates increase insulin secretion in healthy obese subjects.

Journal: The Journal of clinical endocrinology and metabolism 20080701

Title: Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies.

Journal: Journal of pharmaceutical and biomedical analysis 20080213

Title: Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases.

Journal: Allergy 20080101

Title: The inflammatory hypothesis of Alzheimer disease: dead or alive?

Journal: Alzheimer disease and associated disorders 20080101

Title: A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study.

Journal: Alzheimer disease and associated disorders 20080101

Title: Bioequivalence of two oral formulations of triflusal capsules in healthy volunteers.

Journal: Arzneimittel-Forschung 20080101

Title: Inflammaging as a prodrome to Alzheimer's disease.

Journal: Journal of neuroinflammation 20080101

Title: Amiodarone-induced hepatitis and polyneuropathy.

Journal: The Korean journal of internal medicine 20070901

Title: The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

Title: Effects of triflusal and aspirin in a rat model of cerebral ischemia.

Journal: Stroke 20070201

Title: [Trend in platelet antiaggregants utilization in the autonomous community of Valencia, Spain (2000-2005)].

Journal: Revista espanola de salud publica 20070101

Title: Use of aspirin for primary and secondary prevention of cardiovascular disease in diabetic patients in an ambulatory care setting in Spain.

Journal: BMC family practice 20070101

Title: Antithrombotic treatment in atrial fibrillation.

Journal: Expert opinion on drug safety 20060901

Title: Antithrombotic treatment in atrial fibrillation. Response to: Bereznicki LR, Peterson GM, Jackson SL, Jeffrey EC: the risks of warfarin use in the elderly. Expert Opin. Drug Saf. (2006) 5(3):417-431.

Journal: Expert opinion on drug safety 20060701

Title: Platelet microparticles and platelet adhesion: therapeutic implications for the prevention and treatment of stroke.

Journal: Current treatment options in cardiovascular medicine 20060501

Title: Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite.

Journal: Molecular pharmacology 20060401

Title: Upper gastrointestinal bleeding associated with antiplatelet drugs.

Journal: Alimentary pharmacology & therapeutics 20060115

Title: Triflusal: a review of its use in cerebral infarction and myocardial infarction, and as thromboprophylaxis in atrial fibrillation.

Journal: Drugs 20060101

Title: Triflusal: an antiplatelet drug with a neuroprotective effect?

Journal: Cardiovascular drug reviews 20060101

Title: Platelet aggregation inhibitors in primary and secondary prevention of ischemic stroke.

Journal: GMS health technology assessment 20060101

Title: Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus.

Journal: Atherosclerosis 20051201

Title: Review of antiplatelet therapy in secondary prevention of cerebrovascular events: a need for direct comparisons between antiplatelet agents.

Journal: Journal of cardiovascular pharmacology and therapeutics 20050901

Title: Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: II. Effects of triflusal.

Journal: Stroke 20050801

Title: Triflusal for preventing serious vascular events in people at high risk.

Journal: The Cochrane database of systematic reviews 20050720

Title: Randomized clinical stroke trials in 2004.

Journal: Current atherosclerosis reports 20050701

Title: Triflusal versus oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (trac): prospective, randomized, co-operative trial.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050501

Title: Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.

Journal: European journal of clinical pharmacology 20050401

Title: Oral antiplatelet therapy.

Journal: JAMA 20050216

Title: Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050101

Title: Adverse effects and drug interactions of antithrombotic agents used in prevention of ischaemic stroke.

Journal: Drugs 20050101

Title: A new pharmacological effect of salicylates: inhibition of NFAT-dependent transcription.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20041101

Title: Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation: a randomized multicenter study.

Journal: Journal of the American College of Cardiology 20041019

Title: Reconsidering combined antiplatelet and anticoagulant therapy in atrial fibrillation.

Journal: Journal of the American College of Cardiology 20041019

Title: Hydrophilic polymer drug from a derivative of salicylic acid: synthesis, controlled release studies and biological behavior.

Journal: Macromolecular bioscience 20040625

Title: Effects of triflusal on oxidative stress, prostaglandin production and nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices.

Journal: Brain research 20040618

Title: Aspirin: it's hard to beat.

Journal: Neurology 20040413

Title: Triflusal vs aspirin for prevention of cerebral infarction: a randomized stroke study.

Journal: Neurology 20040413

Title: Widespread eczema from triflusal confirmed by patch testing.

Journal: Contact dermatitis 20040401

Title: The stability of 2-acetoxy-4-trifluoromethylbenzoic acid (Triflusal) in micellar pseudophase.

Journal: Journal of pharmaceutical sciences 20040201

Title: Polymeric drugs with prolonged sustained delivery of specific anti-aggregant agents for platelets: kinetic analysis of the release mechanism.

Journal: Journal of biomaterials science. Polymer edition 20040101

Title: [Stroke and Other Thromboembolic Complications of Atrial Fibrillation. Part III. Prevention With Other Antithrombotic Agents.].

Journal: Kardiologiia 20040101

Title: Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

Title: Potential role of mitral valve strands on stroke recurrence in rheumatoid arthritis.

Journal: Arthritis and rheumatism 20031215

Title: Triflusal versus oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (TRAC): rationale and design for a prospective, randomized, co-operative trial.

Journal: Interactive cardiovascular and thoracic surgery 20030601

Title: Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.

Journal: Stroke 20030401

Title: Can aspirin ever be surpassed for stroke prevention?

Journal: Stroke 20030401

Title: Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs.

Journal: European journal of gastroenterology & hepatology 20030201

Title: Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage.

Journal: Stroke 20021001

Title: Compliance of geriatric patients subjected to antiplatelet agents with Triflusal in peripheral arteriopathy. Preliminary data.

Journal: Minerva cardioangiologica 20020601

Title: Platelet aggregation in different antithrombotic regimens. Possible proaggregant effect of low level oral anticoagulation.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20020501

Title: Economic evaluation of triflusal and aspirin in the treatment of acute myocardial infarction.

Journal: PharmacoEconomics 20020101

Title: Photopatch testing in seven cases of photosensitive drug eruptions.

Journal: The Annals of pharmacotherapy 20011201

Title: Triflusal posttreatment inhibits glial nuclear factor-kappaB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain.

Journal: Stroke 20011001

Title: Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.

Journal: Photochemistry and photobiology 20010501

Title: Effect of 4-trifluoromethyl derivatives of salicylate on nuclear factor kappaB-dependent transcription in human astrocytoma cells.

Journal: British journal of pharmacology 20010101

Title: Randomized comparative trial of triflusal and aspirin following acute myocardial infarction.

Journal: European heart journal 20000301

Title: Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.

Journal: Molecular pharmacology 19990401

Title: Fernández de Arriba A, et al. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. Mol Pharmacol. 1999 Apr;55(4):753-60.

Title: Duran, X., et al., Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. J Thromb Haemost, 2008. 6(8): p. 1385-92.

Title: De Miguel, L.S., et al., A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. Eur J Clin Invest, 2000. 30(9): p. 811-7.

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Tags:322-79-2 Molecular Formula|322-79-2 MDL|322-79-2 SMILES|322-79-2 Triflusal