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324523-20-8,MFCD16038896
Catalog No.:AA00C6E3

324523-20-8 | Nps 2143 hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$35.00   $25.00
- +
5mg
98%
in stock  
$86.00   $61.00
- +
10mg
98%
in stock  
$130.00   $91.00
- +
50mg
98%
in stock  
$367.00   $257.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C6E3
Chemical Name:
Nps 2143 hydrochloride
CAS Number:
324523-20-8
Molecular Formula:
C24H26Cl2N2O2
Molecular Weight:
445.3814
MDL Number:
MFCD16038896
SMILES:
N#Cc1c(cccc1Cl)OCC(CNC(Cc1ccc2c(c1)cccc2)(C)C)O.Cl
Properties
Computed Properties
 
Complexity:
560  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  

Downstream Synthesis Route

[1]Johansson,Henrik;Cailly,Thomas;Thomsen,AlexRojasBie;Braeuner-Osborne,Hans;Pedersen,DanielSejer[BeilsteinJournalofOrganicChemistry,2013,vol.9,p.1383-1387]

Literature

Title: Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.

Journal: Journal of medicinal chemistry 20090709

Title: Huang Y, Breitwieser GE. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J Biol Chem. 2007 Mar 30;282(13):9517-25

Title: Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.;Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues. Journal of Medicinal Chemistry (2009), 52(21), 6599-6605.

Title: Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX.Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension.Circ Res. 2012 Aug 3;111(4):469-81. Epub 2012 Jun 22.

Title: Nakajima S, Hira T, Hara H.Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.Mol Nutr Food Res. 2012 May;56(5):753-60.

Title: Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.Endocrinology. 2012 Mar;153(3):1232-41. Epub 2011 Dec 30.

Title: Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

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