Home Other Building Blocks 327613-57-0
327613-57-0,MFCD26408178
Catalog No.:AA00CAW5

327613-57-0 | Amd 15057

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10mg
≥98%(HPLC)
in stock  
$675.00   $473.00
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50mg
≥98%(HPLC)
in stock  
$2,036.00   $1,425.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CAW5
Chemical Name:
Amd 15057
CAS Number:
327613-57-0
Molecular Formula:
C38H46Cl2N6O8S
Molecular Weight:
817.7782
MDL Number:
MFCD26408178
SMILES:
CC(C[C@H](N(C(=O)Cc1ccc(cc1)NC(=O)Nc1ccccc1C)C)C(=O)NCC[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1cc(Cl)cc(c1)Cl)C
Properties
Computed Properties
 
Complexity:
1430  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
16  
XLogP3:
5.3  

Literature

Title: BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.

Journal: Blood 20090813

Title: An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury.

Journal: Experimental neurology 20081201

Title: Modulation of integrin alpha4beta1 (VLA-4) in dry eye disease.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20081201

Title: Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE.

Journal: Blood 20031215

Title: An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Ramirez P, et al. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 2009;114(7):1340‐1343.

Title: Leone DR, et al. An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther. 2003;305(3):1150‐1162.

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