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328541-79-3,MFCD01532954
Catalog No.:AA00C6CY

328541-79-3 | Glyh-101

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$11.00   $8.00
- +
2mg
98+%
in stock  
$17.00   $12.00
- +
5mg
98+%
in stock  
$25.00   $18.00
- +
50mg
98+%
in stock  
$101.00   $71.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6CY
Chemical Name:
Glyh-101
CAS Number:
328541-79-3
Molecular Formula:
C19H15Br2N3O3
Molecular Weight:
493.1487
MDL Number:
MFCD01532954
SMILES:
O=C(CNc1ccc2c(c1)cccc2)NN/C=C/1\C=C(Br)C(=C(C1=O)Br)O
Properties
Computed Properties
 
Complexity:
536  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
4.8  

Literature

Title: Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease.

Journal: Journal of medicinal chemistry 20110811

Title: Protection from carriers of hepatitis B.

Journal: Dimensions in health service 19751201

Title: Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37.

Title: Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr;333(1):60-9.

Title: Barman PP, et al. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochem Biophys Res Commun. 2011 Apr 29;408(1):12-7.

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Tags:328541-79-3 Molecular Formula|328541-79-3 MDL|328541-79-3 SMILES|328541-79-3 Glyh-101