Home Other Building Blocks 330461-64-8
330461-64-8,MFCD01122550
Catalog No.:AA00CJDE

330461-64-8 | AK-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥90%
in stock  
$82.00   $57.00
- +
10mg
≥90%
in stock  
$128.00   $89.00
- +
25mg
≥90%
in stock  
$298.00   $208.00
- +
250mg
98%
in stock  
$2,632.00   $1,843.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CJDE
Chemical Name:
AK-1
CAS Number:
330461-64-8
Molecular Formula:
C19H21N3O5S
Molecular Weight:
403.4521
MDL Number:
MFCD01122550
SMILES:
O=C(c1cccc(c1)S(=O)(=O)N1CCCCCC1)Nc1cccc(c1)[N+](=O)[O-]
Properties
Computed Properties
 
Complexity:
650  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.9  

Literature

Title: 3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2).

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.

Journal: Bioorganic & medicinal chemistry 20110615

Title: Luthi-Carter R, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.

Title: Lee SD, et al. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett. 2016 Apr 1;373(1):138-45.

Title: David M. Taylor, et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6.

Title: Cheon MG, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45.

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