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330942-05-7,MFCD16038040
Catalog No.:AA00C6C5

330942-05-7 | Betrixaban

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Purity
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Price(USD)
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1mg
98%
in stock  
$9.00   $7.00
- +
5mg
98%
in stock  
$18.00   $13.00
- +
10mg
98%
in stock  
$25.00   $18.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C6C5
Chemical Name:
Betrixaban
CAS Number:
330942-05-7
Molecular Formula:
C23H22ClN5O3
Molecular Weight:
451.9055
MDL Number:
MFCD16038040
SMILES:
COc1ccc(c(c1)C(=O)Nc1ccc(cn1)Cl)NC(=O)c1ccc(cc1)C(=N)N(C)C
Properties
Computed Properties
 
Complexity:
668  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
3.6  

Downstream Synthesis Route

[1]Patent:US2007/112039,2007,A1.Locationinpatent:Page/Pagecolumn9-10

[2]Patent:CN105732490,2016,A.Locationinpatent:Paragraph0012;0030;0031;0032;0077;0083;0084

[3]Patent:WO2008/57972,2008,A1.Locationinpatent:Page/Pagecolumn34-35;43-44

[4]Patent:US2008/153876,2008,A1.Locationinpatent:Page/Pagecolumn23-24

[5]Patent:WO2008/57972,2008,A1.Locationinpatent:Page/Pagecolumn34-35

[1]Patent:CN107778223,2018,A.Locationinpatent:Paragraph0037-0038;0044-0045;0051-0052

[2]Patent:US2007/112039,2007,A1.Locationinpatent:Page/Pagecolumn8

[3]Patent:US2007/112039,2007,A1.Locationinpatent:Page/Pagecolumn8

[4]Patent:WO2008/57972,2008,A1.Locationinpatent:Page/Pagecolumn41

[5]Patent:US2008/153876,2008,A1.Locationinpatent:Page/Pagecolumn22

[6]Patent:US2007/112039,2007,A1.Locationinpatent:Page/Pagecolumn11

[7]Patent:US2008/153876,2008,A1.Locationinpatent:Page/Pagecolumn22-23

[8]Patent:WO2017/211779,2017,A1.Locationinpatent:Page/Pagecolumn23

[9]Patent:CN110372582,2019,A.Locationinpatent:Paragraph0018;0022-0023;0027-0028;0032

[1]Patent:US2007/112039,2007,A1.Locationinpatent:Page/Pagecolumn9

[2]Patent:WO2008/57972,2008,A1.Locationinpatent:Page/Pagecolumn42-43

[3]Patent:US2008/153876,2008,A1.Locationinpatent:Page/Pagecolumn23

330942-05-7   
betrixabanmonohydrochloride 

[1]Patent:US2007/112039,2007,A1.Locationinpatent:Page/Pagecolumn11

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.2179-2185

Literature

Title: The role of factor Xa inhibitors in venous thromboembolism treatment.

Journal: Vascular health and risk management 20150101

Title: Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism.

Journal: Vascular health and risk management 20150101

Title: Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa).

Journal: European heart journal 20130521

Title: A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa.

Journal: Nature medicine 20130401

Title: New oral anticoagulants: a review of the literature with particular emphasis on patients with impaired renal function.

Journal: Drugs 20120910

Title: ACP Journal Club: review: factor Xa inhibitors reduce DVT more than LMWH in total knee or hip replacement.

Journal: Annals of internal medicine 20120821

Title: The new oral anticoagulants: a challenge for hospital formularies.

Journal: Hospital practice (1995) 20120801

Title: The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review.

Journal: Expert opinion on therapeutic patents 20120601

Title: Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation.

Journal: Discovery medicine 20120601

Title: Review of atrial fibrillation outcome trials of oral anticoagulant and antiplatelet agents.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301

Title: Oral direct factor Xa inhibitors for stroke prevention in atrial fibrillation.

Journal: Nature reviews. Cardiology 20120227

Title: Stroke Prevention in Atrial Fibrillation: Where are We Now?

Journal: Clinical Medicine Insights. Cardiology 20120101

Title: Current status of new anticoagulants in the management of venous thromboembolism.

Journal: Advances in hematology 20120101

Title: Preventing stroke in atrial fibrillation patients - clinical utility of oral anticoagulants.

Journal: Journal of blood medicine 20120101

Title: Emerging anticoagulants.

Journal: Current medicinal chemistry 20120101

Title: Update on anti-coagulation in atrial fibrillation.

Journal: QJM : monthly journal of the Association of Physicians 20110901

Title: [Thromboembolic prophylaxis 2011: is warfarin on the wane?].

Journal: Giornale italiano di cardiologia (2006) 20110901

Title: Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery.

Journal: Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20110301

Title: New oral anticoagulants: should they replace heparins and warfarin?

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101

Title: Role of factor xa inhibitors in cancer-associated thrombosis: any new data?

Journal: Advances in hematology 20110101

Title: Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments.

Journal: Journal of the American College of Cardiology 20101214

Title: New synthetic antithrombotic agents for venous thromboembolism: pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors.

Journal: Clinics in chest medicine 20101201

Title: Factor Xa inhibitors: next-generation antithrombotic agents.

Journal: Journal of medicinal chemistry 20100909

Title: Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban.

Journal: Journal of clinical pharmacology 20100901

Title: Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.

Journal: Current opinion in cardiology 20100701

Title: New anticoagulants for the prevention of venous thromboembolism.

Journal: Drug design, development and therapy 20100101

Title: Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice.

Journal: F1000 medicine reports 20100101

Title: Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations.

Journal: Journal of blood medicine 20100101

Title: Factor Xa inhibitors--new anticoagulants for secondary haemostasis.

Journal: Hamostaseologie 20090801

Title: New anticoagulants: focus on venous thromboembolism.

Journal: Current vascular pharmacology 20090701

Title: New anticoagulants for atrial fibrillation.

Journal: Seminars in thrombosis and hemostasis 20090701

Title: Rivaroxaban -- an oral, direct Factor Xa inhibitor: lessons from a broad clinical study programme.

Journal: European journal of haematology 20090501

Title: Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.

Journal: Clinical pharmacokinetics 20090101

Title: A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT).

Journal: Thrombosis and haemostasis 20090101

Title: The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants.

Journal: Vascular health and risk management 20090101

Title: Emergence of new oral antithrombotics: a critical appraisal of their clinical potential.

Journal: Vascular health and risk management 20081201

Title: New oral anticoagulants in atrial fibrillation.

Journal: European heart journal 20080101

Title: Oral factor Xa inhibitors for venous thromboembolism prevention in major orthopedic surgery: a review.

Journal: Pathophysiology of haemostasis and thrombosis 20080101

Title: Zhang P, et al. Discovery of Betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):21

Title: Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):446-51.

Title: Chan NC, et al. Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015 Jun 26;11:343-51.

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