Home Other Building Blocks 330981-72-1
330981-72-1,MFCD00298280
Catalog No.:AA00C0TF

330981-72-1 | AS 1269574

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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$133.00   $93.00
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10mg
≥98%
in stock  
$168.00   $117.00
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25mg
≥98%
in stock  
$368.00   $257.00
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100mg
≥98%(HPLC)
in stock  
$1,224.00   $857.00
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250mg
≥98%(HPLC)
in stock  
$2,682.00   $1,878.00
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1g
≥98%(HPLC)
in stock  
$9,504.00   $6,653.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C0TF
Chemical Name:
AS 1269574
CAS Number:
330981-72-1
Molecular Formula:
C13H14BrN3O
Molecular Weight:
308.1738
MDL Number:
MFCD00298280
SMILES:
OCCNc1cc(C)nc(n1)c1ccc(cc1)Br
Properties
Computed Properties
 
Complexity:
246  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartNegoro,Kenji;Yonetoku,Yasuhiro;Maruyama,Tatsuya;Yoshida,Shigeru;Takeuchi,Makoto;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2012,vol.20,#7,p.2369-2375]

[1]Negoro,Kenji;Yonetoku,Yasuhiro;Maruyama,Tatsuya;Yoshida,Shigeru;Takeuchi,Makoto;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2012,vol.20,#7,p.2369-2375]

[1]Negoro,Kenji;Yonetoku,Yasuhiro;Maruyama,Tatsuya;Yoshida,Shigeru;Takeuchi,Makoto;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2012,vol.20,#7,p.2369-2375]

[1]Negoro,Kenji;Yonetoku,Yasuhiro;Maruyama,Tatsuya;Yoshida,Shigeru;Takeuchi,Makoto;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2012,vol.20,#7,p.2369-2375]

Literature

Title: Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists.

Journal: Bioorganic & medicinal chemistry 20120401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion.

Journal: Biochemical and biophysical research communications 20100924

Title: Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400(3):437-441.

Title: Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30(6):614-629.

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SDS
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