Home Other Building Blocks 331248-11-4
331248-11-4,MFCD19690911
Catalog No.:AA00CN7V

331248-11-4 | LG 101506

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Purity
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10mg
≥98%(HPLC)
in stock  
$465.00   $325.00
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50mg
≥98%(HPLC)
in stock  
$1,670.00   $1,169.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CN7V
Chemical Name:
LG 101506
CAS Number:
331248-11-4
Molecular Formula:
C25H34F2O3
Molecular Weight:
420.5325
MDL Number:
MFCD19690911
SMILES:
FC(COc1c(cc(cc1C(C)(C)C)C(C)(C)C)/C(=C\C=C\C(=C\C(=O)O)\C)/C)F
Properties
Computed Properties
 
Complexity:
663  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
8.6  

Literature

Title: Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.

Journal: Molecular endocrinology (Baltimore, Md.) 20090201

Title: Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.

Journal: Endocrinology 20060201

Title: Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.

Journal: Cancer research 20051215

Title: Design, synthesis and structure-activity relationship of novel RXR-selective modulators.

Journal: Bioorganic & medicinal chemistry letters 20040322

Title: Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.

Journal: Bioorganic & medicinal chemistry letters 20031117

Title: Design and synthesis of fluorinated RXR modulators.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.

Journal: Journal of medicinal chemistry 20030911

Title: Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.

Journal: Journal of medicinal chemistry 20030619

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