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3313-26-6,MFCD00079574
Catalog No.:AA003APY

3313-26-6 | (Z)-Thiothixene

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Purity
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5mg
95%
in stock  
$247.00   $173.00
- +
10mg
95%
in stock  
$375.00   $263.00
- +
25mg
95%
in stock  
$672.00   $470.00
- +
50mg
95%
in stock  
$1,165.00   $815.00
- +
100mg
95%
in stock  
$2,049.00   $1,434.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003APY
Chemical Name:
(Z)-Thiothixene
CAS Number:
3313-26-6
Molecular Formula:
C23H29N3O2S2
Molecular Weight:
443.6253
MDL Number:
MFCD00079574
SMILES:
CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C
Properties
Computed Properties
 
Complexity:
711  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
5  
XLogP3:
3.8  

Literature

Title: Network-assisted investigation of antipsychotic drugs and their targets.

Journal: Chemistry & biodiversity 20120501

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: Effect of drug type on the degradation rate of PLGA matrices.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Submissive behavior in mice as a test for antidepressant drug activity.

Journal: Pharmacology, biochemistry, and behavior 20051001

Title: A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.

Journal: Journal of medicinal chemistry 20050421

Title: H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301

Title: Adjunctive quetiapine decreases symptoms of tardive dyskinesia in a patient taking risperidone.

Journal: Clinical neuropharmacology 20030101

Title: Flow-injection chemiluminometric determination of some thioxanthene derivatives in pharmaceutical formulations and biological fluids using the [Ru(dipy)3(2+)]-Ce(IV) system.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20011101

Title: Metabolites of the antipsychotic agent clozapine inhibit the replication of human immunodeficiency virus type 1.

Journal: Schizophrenia research 19970503

Title: Fluoxetine and visual hallucinations in dementia.

Journal: Biological psychiatry 19951015

Title: Neuroleptic-induced extrapyramidal side effects.

Journal: The American journal of psychiatry 19931101

Title: Esophageal atony and dilatation as a side effect of thiothixene and benztropine.

Journal: Hospital & community psychiatry 19930701

Title: On the selection of mice for haloperidol response and non-response.

Journal: Psychopharmacology 19910101

Title: Dropping objects: possible mild cataplexy associated with clozapine.

Journal: The Journal of nervous and mental disease 19901001

Title: Drug-induced dystonia in young and elderly patients.

Journal: The American journal of psychiatry 19880701

Title: Manic syndrome associated with zidovudine treatment.

Journal: JAMA 19880617

Title: Rapid tranquilization: a comparison of thiothixene with loxapine.

Journal: The Journal of clinical psychiatry 19860601

Title: Neuroleptic-induced catatonia after abrupt withdrawal of amantadine during neuroleptic therapy.

Journal: Pharmacotherapy 19860101

Title: Akathisia with haloperidol and thiothixene.

Journal: Archives of general psychiatry 19841101

Title: Drug interactions on spontaneous locomotor activity in rats. Neuroleptics and amphetamine-induced hyperactivity.

Journal: Neuropharmacology 19840801

Title: Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram.

Journal: Journal of clinical psychopharmacology 19840801

Title: Response to antipsychotic medication: the doctor's and the consumer's view.

Journal: The American journal of psychiatry 19840101

Title: Desipramine-associated hepatitis.

Journal: Journal of clinical psychopharmacology 19830801

Title: Neuroleptic malignant syndrome and malignant hyperthermia.

Journal: Lancet (London, England) 19830129

Title: Bromocriptine associated with symptom exacerbation during neuroleptic treatment of schizoaffective schizophrenia.

Journal: The Journal of clinical psychiatry 19820601

Title: Psychopharmacological correlates of post-psychotic depression: a double-blind investigation of haloperidol vs thiothixene in outpatient schizophrenia.

Journal: The Journal of clinical psychiatry 19820301

Title: Neurotoxicity in patients with schizophrenia during lithium therapy.

Journal: Comprehensive psychiatry 19820101

Title: Motility, Parkinsonism, and prolactin with thiothixene and thioridazine.

Journal: Archives of general psychiatry 19810601

Title: Subjective response to antipsychotic drugs.

Journal: Archives of general psychiatry 19810201

Title: Somnambulistic-like episodes secondary to combined lithium-neuroleptic treatment.

Journal: The British journal of psychiatry : the journal of mental science 19791101

Title: Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.

Journal: Journal of the American Geriatrics Society 19790501

Title: Benztropine prophylaxis of dystonic reactions.

Journal: Psychopharmacology 19790328

Title: Fever, tachycardia, and hypertension with acute catatonic schizophrenia.

Journal: Archives of internal medicine 19780701

Title: High-dosage and versatile drug therapy with treatment-resistant psychotic patients.

Journal: Hospital & community psychiatry 19760101

Title: Drug-induced dystonia.

Journal: The American journal of psychiatry 19750501

Title: Once versus thrice daily thiothixene in the treatment of schizophrenic in-patients.

Journal: The British journal of psychiatry : the journal of mental science 19740701

Title: Illana Gozes, et al. Novel compounds and methods for inhibiting cell death. US 20150141345 A1.

Title: Severin G. Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples. J Pharm Sci. 1987 Mar;76(3):231-4.

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