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33231-14-0,MFCD28385844
Catalog No.:AA00C6G4

33231-14-0 | Dz2002

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$216.00   $152.00
- +
2mg
95%
1 week  
$284.00   $199.00
- +
5mg
95%
1 week  
$454.00   $318.00
- +
10mg
95%
1 week  
$626.00   $438.00
- +
25mg
95%
1 week  
$964.00   $675.00
- +
50mg
95%
1 week  
$1,349.00   $944.00
- +
100mg
95%
1 week  
$1,795.00   $1,256.00
- +
500mg
95%
1 week  
$3,452.00   $2,416.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6G4
Chemical Name:
Dz2002
CAS Number:
33231-14-0
Molecular Formula:
C10H13N5O3
Molecular Weight:
251.2419
MDL Number:
MFCD28385844
SMILES:
COC(=O)C(CCn1cnc2c1ncnc2N)O
Properties
Computed Properties
 
Complexity:
303  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.5  

Literature

Title: An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110601

Title: AdoHcy hydrolase of Trichomonas vaginalis: studies of the effects of 5'-modified adenosine analogues and related 6-N-cyclopropyl derivatives.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers.

Journal: Bioorganic & medicinal chemistry 20081015

Title: Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070415

Title: A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Wu QL, et al. Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. J Pharmacol Exp Ther. 2005 May;313(2):705-11.

Title: Fu YF, et al. S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses. J Pharmacol Exp Ther. 2006 Mar;316(3):1229-37.

Title: He SJ, et al. Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response. Acta Pharmacol Sin. 2014 Feb;35(2):219-29.

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