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Home Amines 33286-22-5
33286-22-5,MFCD00069252
Catalog No.:AA003PHI

33286-22-5 | (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$6.00   $4.00
- +
250mg
95%
in stock  
$19.00   $14.00
- +
1g
95%
in stock  
$31.00   $22.00
- +
5g
95%
in stock  
$71.00   $50.00
- +
25g
95%
in stock  
$184.00   $129.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PHI
Chemical Name:
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride
CAS Number:
33286-22-5
Molecular Formula:
C22H27ClN2O4S
Molecular Weight:
450.9788
MDL Number:
MFCD00069252
SMILES:
CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
Properties
Properties
 
Form:
Solid  
MP:
212-214 °C  
Refractive Index:
118 ° (C=1, H2O)  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
565  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  

Literature

Title: Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.

Title: van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.

Title: Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.

Title: Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40.

Title: Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.

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SDS
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Tags:33286-22-5 Molecular Formula|33286-22-5 MDL|33286-22-5 SMILES|33286-22-5 (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride