Home Quinolines 33342-05-1
33342-05-1,MFCD00631870
Catalog No.:AA0034W1

33342-05-1 | 1-cyclohexyl-3-({4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzene}sulfonyl)urea

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1mg
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50mg
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500mg
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5g
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10g
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25g
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100g
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0034W1
Chemical Name:
1-cyclohexyl-3-({4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzene}sulfonyl)urea
CAS Number:
33342-05-1
Molecular Formula:
C27H33N3O6S
Molecular Weight:
527.6324
MDL Number:
MFCD00631870
SMILES:
COc1ccc2c(c1)C(=O)N(C(=O)C2(C)C)CCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Properties
Properties
 
Form:
Solid  
MP:
177-178°C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
948  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.6  

Upstream Synthesis Route

[1]Patent:CN106316950,2017,A,.Locationinpatent:Paragraph0032-0054

Downstream Synthesis Route
108-30-5    33342-05-1   
N-<4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonyl>succinimid 

[1]ArchivderPharmazie,1986,vol.319,p.682-690

[1]ArchivderPharmazie,1986,vol.319,p.682-690

[1]ArchivderPharmazie,1986,vol.319,p.682-690

33342-05-1   
N-Cyclohexyl-N',N''-bis-<4-<2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonyl>guanidin 

[1]ArchivderPharmazie,1987,vol.320,p.253-257

33342-05-1    108-24-7   
N-<4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonyl>acetamid 

[1]ArchivderPharmazie,1986,vol.319,p.682-690

Literature

Title: In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.

Journal: Chemico-biological interactions 20151005

Title: A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101

Title: Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage.

Journal: Journal of toxicology 20120101

Title: Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones.

Journal: Diabetes & metabolism journal 20110801

Title: Gliquidone.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: Impact of clinical factors and CYP2C9 variants for the risk of severe sulfonylurea-induced hypoglycemia.

Journal: European journal of clinical pharmacology 20110501

Title: Simultaneous identification and validated quantification of 11 oral hypoglycaemic drugs in plasma by electrospray ionisation liquid chromatography-mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20110401

Title: Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC.

Journal: Journal of chromatographic science 20110201

Title: Effect of glibenclamide on antinociceptive effects of antidepressants of different classes.

Journal: Clinics (Sao Paulo, Brazil) 20110201

Title: Smoking and risk for diabetes incidence and mortality in Korean men and women.

Journal: Diabetes care 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20101101

Title: Severe sulfonylurea-induced hypoglycemia: a problem of uncritical prescription and deficiencies of diabetes care in geriatric patients.

Journal: Expert opinion on drug safety 20100901

Title: Drug therapy in patients with chronic renal failure.

Journal: Deutsches Arzteblatt international 20100901

Title: Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC.

Journal: Journal of chromatographic science 20100101

Title: Determination of glycyrrhizin in dog plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic studies.

Journal: European journal of mass spectrometry (Chichester, England) 20100101

Title: Twice daily fractionated dose administration of prednisolone compared to standard once daily administration to patients with glomerulonephritis or with kidney transplants.

Journal: Medizinische Klinik (Munich, Germany : 1983) 20090615

Title: Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.

Journal: Diabetes 20090201

Title: Sulfonylurea-induced hypoglycaemia: use of octreotide.

Journal: Acta clinica Belgica 20090101

Title: Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

Journal: BMJ (Clinical research ed.) 20090101

Title: Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

Journal: Diabetes care 20081101

Title: Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction.

Journal: Journal of pharmaceutical and biomedical analysis 20080715

Title: Gliquidone therapy of new-onset diabetes mellitus after kidney transplantation.

Journal: Clinical nephrology 20080701

Title: Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats.

Journal: Journal of veterinary science 20070901

Title: Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

Title: Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Determination of glibenclamide in human plasma by liquid chromatography and atmospheric pressure chemical ionization/MS-MS detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

Title: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach.

Journal: Molecular pharmacology 20070201

Title: Spectrophotometric method for quantitative determination of gliquidone in bulk drug, pharmaceutical formulations and human serum.

Journal: Pakistan journal of pharmaceutical sciences 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: Gliquidone contributes to improvement of type 2 diabetes mellitus management: a review of pharmacokinetic and clinical trial data.

Journal: Drugs in R&D 20060101

Title: Effect of glurenorm on immunohistochemical changes in pancreatic beta cells of rats in experimental diabetes.

Journal: Indian journal of experimental biology 20050301

Title: Protective effects of glurenorm (gliquidone) treatment on the liver injury of experimental diabetes.

Journal: Drug and chemical toxicology 20050101

Title: [Effect of liuwei dihuang pill on erythrocyte aldose reductase activity in early diabetic nephropathy patients].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041201

Title: Improvement of gliquidone hypoglycaemic effect in rats by cyclodextrin formulations.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040901

Title: [Gliquidon induced-desensitization of pancreatic beta cells and the partial reversion of responsiveness after the desensitization of exposure to drug in normal and STZ type 2 diabetic rats].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040501

Title: Enhancement of dissolution and oral bioavailability of gliquidone with hydroxy propyl-beta-cyclodextrin.

Journal: Die Pharmazie 20031101

Title: Hydroxyl-substituted sulfonylureas as potent inhibitors of specific [3H]glyburide binding to rat brain synaptosomes.

Journal: Bioorganic & medicinal chemistry 20030501

Title: [Severe hypoglycemia in diabetics with impaired renal function].

Journal: Deutsche medizinische Wochenschrift (1946) 20030207

Title: Effect of pH and complexation on transdermal permeation of gliquidone.

Journal: Die Pharmazie 20020901

Title: Antiaggregatory activity of hypoglycaemic sulphonylureas.

Journal: Diabetologia 20020701

Title: Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020615

Title: The effect of Glurenorm (gliquidone) on lenses and skin in experimental diabetes.

Journal: Free radical biology & medicine 20011101

Title: Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels.

Journal: British journal of pharmacology 20011001

Title: Role of K+ -channels in homotaurine-induced analgesia.

Journal: Fundamental & clinical pharmacology 20010601

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Tags:33342-05-1 Molecular Formula|33342-05-1 MDL|33342-05-1 SMILES|33342-05-1 1-cyclohexyl-3-({4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzene}sulfonyl)urea