Home Other Building Blocks 334998-36-6
334998-36-6,MFCD20275055
Catalog No.:AA00C8XL

334998-36-6 | CUR 61414

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Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$172.00   $120.00
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10mg
≥98%
in stock  
$326.00   $228.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C8XL
Chemical Name:
CUR 61414
CAS Number:
334998-36-6
Molecular Formula:
C31H42N4O5
Molecular Weight:
550.6890
MDL Number:
MFCD20275055
SMILES:
COc1cccc(c1)CN(C(=O)CC(C)(C)C)[C@H]1C[C@H](N(C1)Cc1ccc2c(c1)OCO2)C(=O)N1CCNCC1
Properties
Properties
 
BP:
714.1±60.0 °C(Predicted)  
Form:
Solid  
MP:
35-40°C  
Storage:
Keep in dry area;-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
859  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
3.3  

Literature

Title: Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.

Journal: Journal of medicinal chemistry 20120223

Title: Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Gli2 expression and human bladder transitional carcinoma cell invasiveness.

Journal: The Journal of urology 20100701

Title: Small-molecule modulators of the Sonic Hedgehog signaling pathway.

Journal: Molecular bioSystems 20100101

Title: Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

Journal: Biochemical and biophysical research communications 20061020

Title: Targeting the hedgehog signaling pathway with small molecules.

Journal: Anti-cancer agents in medicinal chemistry 20060901

Title: Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4.

Title: Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1(2):10.

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