Home Imidazoles 3366-95-8
3366-95-8,MFCD00864656
Catalog No.:AA00I6JX

3366-95-8 | 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol

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50mg
98%
in stock  
$6.00   $4.00
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100mg
98%
in stock  
$7.00   $5.00
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1g
>98.0%(GC)
in stock  
$23.00   $16.00
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5g
98%
in stock  
$24.00   $17.00
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25g
98%
in stock  
$36.00   $25.00
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500g
98%
in stock  
$570.00   $399.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I6JX
Chemical Name:
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
CAS Number:
3366-95-8
Molecular Formula:
C7H11N3O3
Molecular Weight:
185.1805
MDL Number:
MFCD00864656
SMILES:
CC(Cn1c(C)ncc1[N+](=O)[O-])O
NSC Number:
759812
Properties
Computed Properties
 
Complexity:
194  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.2  

Literature

Title: Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs.

Journal: Memorias do Instituto Oswaldo Cruz 20120801

Title: Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors.

Journal: Bioorganic & medicinal chemistry 20120715

Title: Efficacy of the Mentha crispa in the treatment of women with Trichomonas vaginalis infection.

Journal: Archives of gynecology and obstetrics 20120701

Title: Determination of five nitroimidazole residues in artificial porcine muscle tissue samples by capillary electrophoresis.

Journal: Talanta 20120115

Title: Extractional spectrophotometric analysis of metronidazole, tinidazole, ornidazole and secnidazole bases through acid-dye complexation using bromothymol blue dye.

Journal: Pakistan journal of pharmaceutical sciences 20120101

Title: Susceptibility testing of Atopobium vaginae for dequalinium chloride.

Journal: BMC research notes 20120101

Title: A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis.

Journal: Indian journal of pharmacology 20120101

Title: Secnidazole for the treatment of giardiasis in naturally infected cats.

Journal: Parasitology international 20111201

Title: Evaluation of the therapeutic efficacy of Mentha crispa in the treatment of giardiasis.

Journal: Contemporary clinical trials 20111101

Title: Design and gamma scintigraphic evaluation of colon specific pectin-EC pellets of secnidazole prepared by powder layering technology.

Journal: Die Pharmazie 20111101

Title: Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.

Journal: Bioorganic & medicinal chemistry 20110801

Title: Hospitalization of Cuban children for giardiasis: a retrospective study in a paediatric hospital in Havana.

Journal: Annals of tropical medicine and parasitology 20110101

Title: Amoebic dysentery.

Journal: BMJ clinical evidence 20110101

Title: A pseudo-randomised clinical trial of in situ gels of fluconazole for the treatment of oropharngeal candidiasis.

Journal: Trials 20110101

Title: [Development and use of test systems for the evaluation of sensitivity of Trichomonas vaginalisto preparations of the 5-nitroimidazole and 5-nitrofuran groups].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20110101

Title: Antibacterial treatment of bacterial vaginosis: current and emerging therapies.

Journal: International journal of women's health 20110101

Title: [Current approaches to the treatment of non-gonococcal urethritis in men].

Journal: Urologiia (Moscow, Russia : 1999) 20110101

Title: Mebendazole compared with secnidazole in the treatment of adult giardiasis: a randomised, no-inferiority, open clinical trial.

Journal: Journal of parasitology research 20110101

Title: Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Preparation and characterization of a molecularly imprinted monolithic column for pressure-assisted CEC separation of nitroimidazole drugs.

Journal: Electrophoresis 20100801

Title: A molecularly imprinted monolith for the fast chiral separation of antiparasitic drugs by pressurized CEC.

Journal: Journal of separation science 20100701

Title: Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.

Journal: British journal of clinical pharmacology 20100601

Title: In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100501

Title: A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis.

Journal: PLoS neglected tropical diseases 20100501

Title: Secnidazole-induced acute pancreatitis: a new side-effect for an old drug?

Journal: JOP : Journal of the pancreas 20100108

Title: Could giardiasis be a risk factor for low zinc status in schoolchildren from northwestern Mexico? A cross-sectional study with longitudinal follow-up.

Journal: BMC public health 20100101

Title: Treatment of bacterial vaginosis: a multicenter, double-blind, double-dummy, randomised phase III study comparing secnidazole and metronidazole.

Journal: Infectious diseases in obstetrics and gynecology 20100101

Title: [Using safocid for antibiotic prophylaxis in minimally-invasive endoscopic operations and manipulations].

Journal: Urologiia (Moscow, Russia : 1999) 20100101

Title: Infectious diseases and prematurity.

Journal: Infectious diseases in obstetrics and gynecology 20100101

Title: Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for Helicobacter pylori eradication in dyspepsia.

Journal: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20091001

Title: Prevalence and chemotherapy of Balantidium coli in cattle in the River Ravi region, Lahore (Pakistan).

Journal: Veterinary parasitology 20090707

Title: Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20090501

Title: Formulation and in vitro evaluation of in situ gels containing secnidazole for vaginitis.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090501

Title: [In vitro effect of secnidazole benzoate on Trichomonas vaginalis].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20090401

Title: Molecular structure and vibrational spectroscopic investigation of secnidazole using density functional theory.

Journal: The journal of physical chemistry. A 20090108

Title: Antibody response in children infected with Giardia intestinalis before and after treatment with Secnidazole.

Journal: The American journal of tropical medicine and hygiene 20090101

Title: Validated method for determination of eight banned nitroimidazole residues in natural casings by LC/MS/MS with solid-phase extraction.

Journal: Journal of AOAC International 20090101

Title: The old and new therapeutic approaches to the treatment of giardiasis: where are we?

Journal: Biologics : targets & therapy 20090101

Title: A Stability-Indicating RP-HPLC Assay Method for 5-Fluorouracil.

Journal: Indian journal of pharmaceutical sciences 20090101

Title: Formulation and evaluation of secnidazole or doxycycline dento-oral gels.

Journal: Drug development and industrial pharmacy 20081201

Title: Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis.

Journal: AAPS PharmSciTech 20080901

Title: [Efficacy of 5-nitroimidazole derivatives in treatment of bacterial vaginosis].

Journal: Zhonghua yi xue za zhi 20080812

Title: Short-term triple therapy with azithromycin for Helicobacter pylori eradication: low cost, high compliance, but low efficacy.

Journal: BMC gastroenterology 20080101

Title: Role of cytochrome P450 in drug interactions.

Journal: Nutrition & metabolism 20080101

Title: Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection.

Journal: Parasites & vectors 20080101

Title: The concept of personal drugs in the undergraduate pharmacology practical curriculum.

Journal: Indian journal of pharmacology 20080101

Title: Simultaneous determination of seven nitroimidazole residues in meat by using HPLC-UV detection with solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

Title: Determination of secnidazole in human plasma by high-performance liquid chromatography with UV detection and its application to the bioequivalence studies.

Journal: Biomedical chromatography : BMC 20070301

Title: Evaluation of the bioequivalence and pharmacokinetics of two formulations of secnidazole after single oral administration in healthy volunteers.

Journal: Arzneimittel-Forschung 20070101

Title: Prescription of fixed dose combination drugs for diarrhoea.

Journal: Indian journal of medical ethics 20070101

Title: Amoebic dysentery.

Journal: BMJ clinical evidence 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Short-term therapy for mixed vaginal infections.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20060201

Title: Comparative efficacy of two regimens in syndromic management of lower genital infections.

Journal: Archives of gynecology and obstetrics 20060101

Title: Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study.

Journal: Sao Paulo medical journal = Revista paulista de medicina 20050502

Title: Low-dose secnidazole in the treatment of bacterial vaginosis.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20050301

Title: Probing NMR parameters, structure and dynamics of 5-nitroimidazole derivatives. Density functional study of prototypical radiosensitizers.

Journal: Magnetic resonance in chemistry : MRC 20050201

Title: ICH guidance in practice: establishment of inherent stability of secnidazole and development of a validated stability-indicating high-performance liquid chromatographic assay method.

Journal: Journal of pharmaceutical and biomedical analysis 20041119

Title: Spectrophotometric determination of metronidazole and secnidazole in pharmaceutical preparations.

Journal: Farmaco (Societa chimica italiana : 1989) 20041001

Title: [New drugs for the treatment of human parasitic protozoa].

Journal: Parassitologia 20040601

Title: Ciprofloxacin-tinidazole combination, fluconazole- azithromicin-secnidazole-kit and doxycycline- metronidazole combination therapy in syndromic management of pelvic inflammatory disease: a prospective randomized controlled trial.

Journal: Indian journal of medical sciences 20031201

Title: A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis.

Journal: Annals of tropical medicine and parasitology 20030701

Title: Nitroheterocyclic drugs with broad spectrum activity.

Journal: Parasitology research 20030601

Title: Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20030201

Title: Pre and post eradication gastric inflammation in Helicobacter pylori-associated duodenal ulcer.

Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20020101

Title: Low efficacy of an ultra-short term, once-daily dose triple therapy with omeprazole, azithromycin, and secnidazole for Helicobacter pylori eradication in peptic ulcer.

Journal: Revista do Hospital das Clinicas 20020101

Title: Randomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study.

Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20010101

Title: Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis.

Journal: Drugs 19960401

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SDS
Tags:3366-95-8 Molecular Formula|3366-95-8 MDL|3366-95-8 SMILES|3366-95-8 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol