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33868-03-0,MFCD00005713
Catalog No.:AA007IJV

33868-03-0 | 1H-Purine-2,6,8(3H)-trione,7,9-dihydro-1,7-dimethyl-

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25mg
≥98%
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$98.00   $68.00
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50mg
≥98%
in stock  
$173.00   $121.00
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100mg
≥98%
in stock  
$328.00   $229.00
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250mg
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$573.00   $401.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007IJV
Chemical Name:
1H-Purine-2,6,8(3H)-trione,7,9-dihydro-1,7-dimethyl-
CAS Number:
33868-03-0
Molecular Formula:
C7H8N4O3
Molecular Weight:
196.1634
MDL Number:
MFCD00005713
SMILES:
Cn1c(=O)[nH]c2c1c(=O)n(c(=O)[nH]2)C
Properties
Computed Properties
 
Complexity:
386  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
XLogP3:
-0.2  

Literature

Title: Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers.

Journal: The Annals of pharmacotherapy 20100601

Title: Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.

Journal: Clinical and experimental pharmacology & physiology 20090801

Title: CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.

Journal: Human & experimental toxicology 20080501

Title: Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.

Journal: Basic & clinical pharmacology & toxicology 20080101

Title: Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.

Journal: Clinica chimica acta; international journal of clinical chemistry 20070201

Title: In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.

Journal: Biomedical chromatography : BMC 20070201

Title: Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice.

Journal: Neuromolecular medicine 20070101

Title: Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.

Journal: European journal of clinical pharmacology 20061201

Title: [Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060301

Title: Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20050301

Title: Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples.

Journal: Journal of separation science 20041001

Title: Catabolism of caffeine in plants and microorganisms.

Journal: Frontiers in bioscience : a journal and virtual library 20040501

Title: Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.

Journal: Breast cancer research : BCR 20040101

Title: Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.

Journal: British journal of clinical pharmacology 20030201

Title: Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.

Journal: Toxicology 20021227

Title: Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.

Journal: Clinical pharmacology and therapeutics 20020801

Title: A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test.

Journal: Clinical pharmacology and therapeutics 20020801

Title: CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020401

Title: Urinary biomarkers for assessing dietary exposure to caffeine.

Journal: Food additives and contaminants 20011201

Title: Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010815

Title: The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans.

Journal: Clinical pharmacology and therapeutics 20010801

Title: Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010505

Title: Caffeine metabolism before and after liver transplantation.

Journal: International journal of clinical pharmacology and therapeutics 20010201

Title: Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis.

Journal: International journal of clinical pharmacology and therapeutics 20010101

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Tags:33868-03-0 Molecular Formula|33868-03-0 MDL|33868-03-0 SMILES|33868-03-0 1H-Purine-2,6,8(3H)-trione,7,9-dihydro-1,7-dimethyl-