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338747-41-4,MFCD01315710
Catalog No.:AA00D4SQ

338747-41-4 | 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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5mg
≥98%
in stock  
$89.00   $62.00
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10mg
≥98%
in stock  
$138.00   $96.00
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25mg
≥98%
in stock  
$322.00   $225.00
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100mg
95%
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$446.00   $312.00
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250mg
95%
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$684.00   $479.00
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1g
95%
in stock  
$1,303.00   $912.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00D4SQ
Chemical Name:
1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS Number:
338747-41-4
Molecular Formula:
C18H15NO4
Molecular Weight:
309.3160
MDL Number:
MFCD01315710
SMILES:
COc1ccc(cc1)Cn1cc(C(=O)O)c(=O)c2c1cccc2
Properties
Computed Properties
 
Complexity:
493  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.4  

Literature

Title: Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

Journal: Journal of medicinal chemistry 20110714

Title: Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

Journal: Bioorganic & medicinal chemistry letters 20110315

Title: Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.

Journal: Bioorganic & medicinal chemistry letters 20100415

Title: N-heterocyclic derived M1 positive allosteric modulators.

Journal: Bioorganic & medicinal chemistry letters 20100215

Title: Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Ma L, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15950-5.

Title: Shirey JK, et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptorincreases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009 Nov 11;29(45):14271-86.

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SDS
Tags:338747-41-4 Molecular Formula|338747-41-4 MDL|338747-41-4 SMILES|338747-41-4 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid