Title: Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.
Journal: Plant & cell physiology20120901
Title: Fungal sensitivity to and enzymatic deglycosylation of ginsenosides.
Journal: Phytochemistry20120601
Title: Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the Akt-dependent phosphorylation of endothelial nitric oxide synthase.
Journal: Journal of agricultural and food chemistry20120328
Title: Protective effect of ginseng sapogenins against 2,2'-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK₁ cell damage.
Journal: Bioorganic & medicinal chemistry letters20120101
Title: The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives.
Journal: Molecules (Basel, Switzerland)20111219
Title: A novel ginsenosidase from an Aspergillus strain hydrolyzing 6-O-multi-glycosides of protopanaxatriol-type ginsenosides, named ginsenosidase type IV.
Journal: Journal of microbiology and biotechnology20111001
Title: Simultaneous determination of ginsenoside (G-Re, G-Rg1, G-Rg2, G-F1, G-Rh1) and protopanaxatriol in human plasma and urine by LC-MS/MS and its application in a pharmacokinetics study of G-Re in volunteers.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20110715
Title: Protopanaxatriol-type ginsenosides from the root of Panax ginseng.
Journal: Journal of agricultural and food chemistry20110112
Title: Effect of 20(S)-protopanaxatriol and its epimeric derivatives on myocardial injury induced by isoproterenol.
Journal: Arzneimittel-Forschung20110101
Title: Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.
Journal: Fitoterapia20101201
Title: Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship.
Journal: Drug metabolism and disposition: the biological fate of chemicals20101001
Title: [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100501
Title: Protopanaxatriol metabolites identified by LC-MS/MS after oral administration in mice.
Journal: International journal of clinical pharmacology and therapeutics20100401
Title: The ginsenoside protopanaxatriol protects endothelial cells from hydrogen peroxide-induced cell injury and cell death by modulating intracellular redox status.
Journal: Free radical biology & medicine20100201
Title: Isolation, synthesis and structures of ginsenoside derivatives and their anti-tumor bioactivity.
Journal: Molecules (Basel, Switzerland)20100119
Title: Microbial conversion of rare ginsenoside Rf to 20(S)-protopanaxatriol by Aspergillus niger.
Journal: Bioscience, biotechnology, and biochemistry20100101
Title: Antioxidant and apoptotic effects of korean white ginseng extracted with the same ratio of protopanaxadiol and protopanaxatriol saponins in human hepatoma HepG2 cells.
Journal: Annals of the New York Academy of Sciences20090801
Title: Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol.
Journal: Journal of pharmacological sciences20090401
Title: Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells.
Journal: British journal of pharmacology20090201
Title: Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng.
Journal: Phytotherapy research : PTR20090101
Title: Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study.
Journal: European journal of mass spectrometry (Chichester, England)20090101
Title: [Clinical value of protoparaxotril saporlirs combined with aspirin in the secondary prevention of cerebral infarction].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine20080901
Title: Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.
Journal: Journal of natural products20080301
Title: Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products.
Journal: Phytochemistry20071001
Title: Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
Journal: Journal of natural products20070701
Title: Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice.
Journal: Vaccine20070122
Title: [Analysis of ginsenosides in Sheng-Mai-Yin decoction by high performance liquid chromatography-diode array detection-electrospray mass spectrometry].
Journal: Se pu = Chinese journal of chromatography20060701
Title: Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20060601
Title: Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain.
Journal: European journal of pharmacology20060113
Title: Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng.
Journal: International immunopharmacology20060101
Title: Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus.
Journal: Journal of natural products20050501
Title: Protopanaxatriol-type ginsenosides differentially modulate type 1 and type 2 cytokines production from murine splenocytes.
Journal: Planta medica20050301
Title: Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells.
Journal: Acta pharmacologica Sinica20041201
Title: The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity.
Journal: Biological & pharmaceutical bulletin20041001
Title: 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide.
Journal: Cancer letters20040308
Title: Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2.
Journal: Canadian journal of physiology and pharmacology20040301
Title: In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins.
Journal: Biochemical pharmacology20031201
Title: Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes.
Journal: Archives of pharmacal research20031001
Title: Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng.
Journal: Planta medica20030301
Title: Ginsenosides inhibit EGF-induced proliferation of renal proximal tubule cells via decrease of c-fos and c-jun gene expression in vitro.
Journal: Planta medica20021101
Title: Can ginsenosides protect human erythrocytes against free-radical-induced hemolysis?
Journal: Biochimica et biophysica acta20020815
Title: Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol.
Journal: Biological & pharmaceutical bulletin20020701
Title: Ginsenosides protect apical transporters of cultured proximal tubule cells from dysfunctions induced by h(2)o(2).
Journal: Kidney & blood pressure research20020101
Title: Regioselective enzymatic glycosylation of natural polyhydroxylated compounds: galactosylation and glucosylation of protopanaxatriol ginsenosides.
Journal: The Journal of organic chemistry20010112
Title: Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice.
Journal: Journal of ethnopharmacology19990801
Title: Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37.
Title: Oh GS, et al. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7.
Title: Huang Q, et al. Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer. J Exp Clin Cancer Res. 2019;38(1):129. Published 2019 Mar 15.
Title: Zhang H, et al. 20(S)-Protopanaxadiol-Induced Apoptosis in MCF-7 Breast Cancer Cell Line through the Inhibition of PI3K/AKT/mTOR Signaling Pathway. Int J Mol Sci. 2018;19(4):1053. Published 2018 Apr 2.
