34273-10-4,MFCD00167510
Catalog No.:AA01E452

34273-10-4 | Saralasin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
in stock  
$377.00   $264.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01E452
Chemical Name:
Saralasin
CAS Number:
34273-10-4
Molecular Formula:
C42H65N13O10
Molecular Weight:
912.0466
MDL Number:
MFCD00167510
SMILES:
CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C)Cc1nc[nH]c1)C(C)C)Cc1ccc(cc1)O)C(C)C)CCCNC(=N)N
Properties
Computed Properties
 
Complexity:
1670  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
12  
Isotope Atom Count:
0  
Rotatable Bond Count:
25  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-2.6  

Literature

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry 20130501

Title: Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-β1 and PAI-1 expression in renal mesangial cells.

Journal: American journal of physiology. Renal physiology 20120701

Title: Angiotensin II, progesterone, and prostaglandins are sequential steps in the pathway to bovine oocyte nuclear maturation.

Journal: Theriogenology 20120601

Title: Quantitative modeling of the physiology of ascites in portal hypertension.

Journal: BMC gastroenterology 20120101

Title: Angiotensin II signaling promotes follicle growth and dominance in cattle.

Journal: Endocrinology 20111201

Title: Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20111101

Title: Intracellular angiotensin II activates rat myometrium.

Journal: American journal of physiology. Cell physiology 20110901

Title: Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

Journal: Frontiers in pharmacology 20110101

Title: Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits.

Journal: Frontiers in physiology 20110101

Title: Hypertension and other morbidities with Cushing's syndrome associated with corticosteroids: a review.

Journal: Integrated blood pressure control 20110101

Title: Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus.

Journal: Neurobiology of learning and memory 20101101

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study.

Journal: Phytotherapy research : PTR 20100901

Title: Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory.

Journal: Heart rhythm 20100701

Title: Brain renin-angiotensin system modifies the blood pressure response to intracerebroventricular cadmium in rats.

Journal: Drug and chemical toxicology 20100701

Title: Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401

Title: Angiotensin II type 1 receptor blockade: high hopes sent back to reality?

Journal: Minerva cardioangiologica 20091201

Title: Angiotensin II induces apoptosis in human mural granulosa-lutein cells, but not in cumulus cells.

Journal: Fertility and sterility 20090501

Title: Two dissimilar AT(1) agonists distinctively activate AT(1) receptors located on the luminal membrane of coronary endothelium.

Journal: Vascular pharmacology 20090101

Title: Evidence that the effect of angiotensin II on bovine oocyte nuclear maturation is mediated by prostaglandins E2 and F2alpha.

Journal: Reproduction (Cambridge, England) 20081201

Title: Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium.

Journal: European journal of heart failure 20081201

Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Journal: Journal of medicinal chemistry 20081127

Title: Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells.

Journal: American journal of physiology. Endocrinology and metabolism 20081001

Title: Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium.

Journal: Cardiovascular research 20080901

Title: Physiological effects of complexes of angiotensins with functionally different carrier proteins.

Journal: Bulletin of experimental biology and medicine 20080801

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry 20080724

Title: Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080701

Title: Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080601

Title: The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?

Journal: Vascular health and risk management 20080601

Title: Angiotensin II- and glucose-stimulated extracellular matrix production: mediation by the insulin-like growth factor (IGF) axis in a murine mesangial cell line.

Journal: Endocrine 20080201

Title: Importance and limits of ischemia in renal partial surgery: experimental and clinical research.

Journal: Advances in urology 20080101

Title: Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling.

Journal: American journal of respiratory cell and molecular biology 20071201

Title: Cardiovascular effects of centrally injected melittin in hemorrhaged hypotensive rats: the investigation of peripheral mechanisms.

Journal: Neuropeptides 20071201

Title: Effect of angiotensin II receptor blocker on glucose-induced mRNA expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rat mesangial cells.

Journal: Chinese medical journal 20071105

Title: The role of angiotensin II in the early stages of bovine ovulation.

Journal: Reproduction (Cambridge, England) 20071101

Title: Interaction between endothelin and angiotensin II in the up-regulation of vasopressin messenger RNA in the inner medullary collecting duct of the rat.

Journal: Metabolism: clinical and experimental 20071001

Title: Role of the brain renin-angiotensin system in blood pressure regulation.

Journal: Veterinary research communications 20070801

Title: Role of the AT1A receptor in the CO2-induced stimulation of HCO3- reabsorption by renal proximal tubules.

Journal: American journal of physiology. Renal physiology 20070701

Title: Cardiovascular response to renin substrate microinjection into the central nucleus of the amygdala of rats.

Journal: Neuroreport 20070507

Title: Role of the vasodilator peptide angiotensin-(1-7) in cardiovascular drug therapy.

Journal: Vascular health and risk management 20070201

Title: Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages.

Journal: Current pharmaceutical design 20070101

Title: Regulation of cGMP synthesis in cultured podocytes by vasoactive hormones.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061201

Title: Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060906

Title: Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid.

Journal: Life sciences 20060501

Title: Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans.

Journal: Diabetologia 20060201

Title: A non-radioactive method for angiotensin II receptor binding studies using the rat liver.

Journal: Journal of pharmacological and toxicological methods 20060101

Title: Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.

Journal: Breast cancer research : BCR 20060101

Title: Angiotensin II and III upregulate body fluid volume of the clam worm Perinereis sp. via angiotensin II receptors in different manners.

Journal: Peptides 20051201

Title: Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblastsdagger.

Journal: Fundamental & clinical pharmacology 20051201

Title: Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II.

Journal: The European journal of neuroscience 20051001

Title: Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia.

Journal: British journal of cancer 20050822

Title: Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20050601

Title: Angiotensin II receptor inhibition prevents pneumocyte apoptosis in surfactant-depleted rat lungs.

Journal: Pediatric pulmonology 20050401

Title: Angiotensin II reverses the inhibitory action produced by theca cells on bovine oocyte nuclear maturation.

Journal: Theriogenology 20050301

Title: Angiotensin II inhibition of Ca2+ currents is independent of ATR1 angiotensin II receptor activation in rat adult vagal afferent neurons.

Journal: Autonomic neuroscience : basic & clinical 20050207

Title: A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception.

Journal: Neuroscience 20050101

Title: Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors.

Journal: Circulation research 20040625

Title: Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040301

Title: Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration.

Journal: Pediatric research 20040201

Title: Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats.

Journal: Psychoneuroendocrinology 20040101

Title: Stimulation of NHE3 in OKP cells by an autocrine mechanism.

Journal: Nephron. Experimental nephrology 20040101

Title: Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs.

Journal: Critical care (London, England) 20040101

Title: Intracoronary angiotensin II causes inotropic and vascular effects via different paracrine mechanisms.

Journal: Vascular pharmacology 20040101

Title: Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response.

Journal: Regulatory peptides 20031115

Title: Cardiac memory is associated with decreased levels of the transcriptional factor CREB modulated by angiotensin II and calcium.

Journal: Circulation research 20030905

Title: Microinjection of renin-angiotensin system peptides in discrete sites within the rat periaqueductal gray matter elicits antinociception.

Journal: Brain research 20030516

Title: Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin.

Journal: American journal of physiology. Heart and circulatory physiology 20030401

Title: Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis.

Journal: Pancreas 20030401

Title: Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats.

Journal: Journal of hypertension 20030401

Title: Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area.

Journal: Arquivos brasileiros de cardiologia 20030401

Title: Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis.

Journal: Regulatory peptides 20030328

Title: Bleomycin-induced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novo.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030301

Title: Reduced dipsogenic response induced by angiotensin II activation of subfornical organ projections to the median preoptic nucleus in estrogen-treated rats.

Journal: Experimental neurology 20030101

Title: The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.

Journal: Acta physiologica et pharmacologica Bulgarica 20030101

Title: Angiotensin AT(1)-receptors depolarize neonatal spinal motoneurons and other ventral horn neurons via two different conductances.

Journal: Journal of neurophysiology 20021101

Title: Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Angiotensin II vs its type I antagonists: conformational requirements for receptor binding assessed from NMR spectroscopic and receptor docking experiments.

Journal: Journal of medicinal chemistry 20020926

Title: Alpha-adrenergic control of ANG II-induced drinking in the rat median preoptic nucleus.

Journal: Physiology & behavior 20020901

Title: Involvement of the AT(2)-receptor in angiotensin II-induced facilitation of sympathetic neurotransmission.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20020901

Title: Influence of ANG II on cytoplasmic sodium in cultured rabbit nonpigmented ciliary epithelium.

Journal: American journal of physiology. Cell physiology 20020801

Title: Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020801

Title: Decreased monoamine release in the median preoptic area following ventricular treatment with the angiotensin II antagonist saralasin in normotensive and spontaneously hypertensive rats.

Journal: Regulatory peptides 20020715

Title: The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake.

Journal: Methods and findings in experimental and clinical pharmacology 20020601

Title: Attenuated drinking response induced by angiotensinergic activation of subfornical organ projections to the paraventricular nucleus in estrogen-treated rats.

Journal: Neuroscience letters 20020524

Title: Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor.

Journal: Regulatory peptides 20020115

Title: Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats.

Journal: The Journal of physiology 20020101

Title: Effect of angiotensin II on ANP-dependent guanylyl cyclase activity in cultured mouse and rat podocytes.

Journal: Kidney & blood pressure research 20020101

Title: Angiotensin II and the transcription factor Rel/NF-kappaB link environmental water shortage with memory improvement.

Journal: Neuroscience 20020101

Title: Renal nuclear angiotensin II receptors in normal and hypertensive rats.

Journal: Acta physiologica Hungarica 20020101

Title: Inhibition of the formation or action of angiotensin II reverses attenuated K+ currents in type 1 and type 2 diabetes.

Journal: The Journal of physiology 20011115

Title: Estrogen decreases the responsiveness of subfornical organ neurons to angiotensinergic neural inputs from the lateral hypothalamic area in the female rat.

Journal: Experimental neurology 20011001

Title: Inhibitory effect of the angiotensin converting enzyme inhibitors captopril and enalapril on the conversion of procollagen to collagen.

Journal: Journal of hypertension 20011001

Title: Effects of central angiotensin II receptor antagonism on fetal swallowing and cardiovascular activity.

Journal: American journal of obstetrics and gynecology 20011001

Title: [The cellular mechanism of angiotensin II inhibition on BKCa of ECV304 cell and the protective effect of gingko leaf extract].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20011001

Title: Norepinephrine induces alveolar epithelial apoptosis mediated by alpha-, beta-, and angiotensin receptor activation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010901

Title: Differentiation in the angiotensin II receptor 1 blocker class on autonomic function.

Journal: Current hypertension reports 20010901

Title: Respiratory and metabolic effects of decreased osmolality in conscious rats.

Journal: Canadian journal of physiology and pharmacology 20010901

Title: Cardiorespiratory effects of prolonged angiotensin II block in resting conscious dogs.

Journal: Canadian journal of physiology and pharmacology 20010901

Title: Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20010901

Title: Estrogen attenuates the drinking response induced by activation of angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in female rats.

Journal: Behavioural brain research 20010701

Title: Angiotensin regulates endothelin-B receptor in rat inner medullary collecting duct.

Journal: Metabolism: clinical and experimental 20010601

Title: Angiotensin II priming of aldosterone secretion with agents that enhance Ca(2+) influx.

Journal: Molecular and cellular endocrinology 20010525

Title: Angiotensin II elicits water seeking behavior and the water absorption response in the toad Bufo bufo.

Journal: Hormones and behavior 20010501

Title: Angiotensin receptor in the heart of Bothrops jararaca snake.

Journal: European journal of pharmacology 20010406

Title: Activation of the subfornical organ enhances extracellular noradrenaline concentrations in the hypothalamic paraventricular nucleus in the rat.

Journal: Brain research bulletin 20010301

Title: Angiotensin II type 1 receptor blockers.

Journal: Circulation 20010213

Title: Role of angiotensin and its inhibition in hypertension, ischemic heart disease, and heart failure.

Journal: Hypertension (Dallas, Tex. : 1979) 20010201

Title: Dipsogenic response induced by angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in rats.

Journal: Behavioural brain research 20010129

Title: Angiotensinergic and noradrenergic mechanisms in the hypothalamic paraventricular nucleus participate in the drinking response induced by activation of the subfornical organ in rats.

Journal: Behavioural brain research 20010129

Title: Angiotensin II increases neurogenic nitric oxide metabolism in mesenteric arteries from hypertensive rats.

Journal: Life sciences 20010126

Title: Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle.

Journal: Pflugers Archiv : European journal of physiology 20010101

Title: Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19961015

Title: Angiotensin II antagonists.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 19931101

Title: Characterization of [3H]losartan receptors in isolated rat glomeruli.

Journal: European journal of pharmacology 19931015

Title: Multiple binding modes for the receptor-bound conformations of cyclic AII agonists.

Journal: Journal of medicinal chemistry 19930625

Title: Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells.

Journal: Regulatory peptides 19930319

Title: Renin-angiotensin system stimulates respiration during acute hypotension but not during hypercapnia.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 19930301

Title: Angiotensin in the brain suppresses epinephrine-induced cardiac arrhythmias through CNS opioid mechanisms.

Journal: Life sciences 19910101

Title: Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs.

Journal: Clinical and experimental hypertension. Part A, Theory and practice 19910101

Title: Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Journal: The Journal of clinical investigation 19901101

Title: Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.

Journal: Molecular pharmacology 19900301

Title: Angiotensin II as a modulator of baroreceptor reflexes in the brainstem of conscious rats.

Journal: Hypertension (Dallas, Tex. : 1979) 19900201

Title: Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome.

Journal: The Journal of clinical investigation 19830101

Title: Addition of acebutolol to diuretics in hypertension.

Journal: Clinical pharmacology and therapeutics 19811201

Title: Etiopathogenesis of excess methylprednisolone arterial hypertension in the rat.

Journal: Clinical and experimental hypertension 19810101

Title: Role of the anteroventral third ventricle region and the renin angiotensin system in methylprednisolone hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 19810101

Title: Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats.

Journal: Anesthesiology 19800201

Title: Effect of Sar1-ala8-angiotensin II on blood pressure and renin in Bartter's syndrome, before and after treatment with prostaglandin synthetase inhibitors.

Journal: Scandinavian journal of clinical and laboratory investigation 19791001

Title: Dopamine and saralasin antagonism of renal vasoconstriction and oliguria caused by amphotericin B in dogs.

Journal: The Journal of infectious diseases 19791001

Title: Severe hypotension before saralasin infusion.

Journal: Lancet (London, England) 19790707

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Tags:34273-10-4 Molecular Formula|34273-10-4 MDL|34273-10-4 SMILES|34273-10-4 Saralasin
Catalog No.: AA01E452
34273-10-4,MFCD00167510
34273-10-4 | Saralasin
Pack Size: 5mg
Purity:
in stock
$377.00 $264.00
Quantity
- +
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Technical Information
Catalog Number: AA01E452
Chemical Name: Saralasin
CAS Number: 34273-10-4
Molecular Formula: C42H65N13O10
Molecular Weight: 912.0466
MDL Number: MFCD00167510
SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C)Cc1nc[nH]c1)C(C)C)Cc1ccc(cc1)O)C(C)C)CCCNC(=N)N
Properties
Complexity: 1670  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 7  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 65  
Hydrogen Bond Acceptor Count: 13  
Hydrogen Bond Donor Count: 12  
Isotope Atom Count: 0  
Rotatable Bond Count: 25  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -2.6  
Literature fold

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry20130501

Title: Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-β1 and PAI-1 expression in renal mesangial cells.

Journal: American journal of physiology. Renal physiology20120701

Title: Angiotensin II, progesterone, and prostaglandins are sequential steps in the pathway to bovine oocyte nuclear maturation.

Journal: Theriogenology20120601

Title: Quantitative modeling of the physiology of ascites in portal hypertension.

Journal: BMC gastroenterology20120101

Title: Angiotensin II signaling promotes follicle growth and dominance in cattle.

Journal: Endocrinology20111201

Title: Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20111101

Title: Intracellular angiotensin II activates rat myometrium.

Journal: American journal of physiology. Cell physiology20110901

Title: Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

Journal: Frontiers in pharmacology20110101

Title: Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits.

Journal: Frontiers in physiology20110101

Title: Hypertension and other morbidities with Cushing's syndrome associated with corticosteroids: a review.

Journal: Integrated blood pressure control20110101

Title: Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus.

Journal: Neurobiology of learning and memory20101101

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry20101101

Title: Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study.

Journal: Phytotherapy research : PTR20100901

Title: Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory.

Journal: Heart rhythm20100701

Title: Brain renin-angiotensin system modifies the blood pressure response to intracerebroventricular cadmium in rats.

Journal: Drug and chemical toxicology20100701

Title: Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20100401

Title: Angiotensin II type 1 receptor blockade: high hopes sent back to reality?

Journal: Minerva cardioangiologica20091201

Title: Angiotensin II induces apoptosis in human mural granulosa-lutein cells, but not in cumulus cells.

Journal: Fertility and sterility20090501

Title: Two dissimilar AT(1) agonists distinctively activate AT(1) receptors located on the luminal membrane of coronary endothelium.

Journal: Vascular pharmacology20090101

Title: Evidence that the effect of angiotensin II on bovine oocyte nuclear maturation is mediated by prostaglandins E2 and F2alpha.

Journal: Reproduction (Cambridge, England)20081201

Title: Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium.

Journal: European journal of heart failure20081201

Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Journal: Journal of medicinal chemistry20081127

Title: Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells.

Journal: American journal of physiology. Endocrinology and metabolism20081001

Title: Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium.

Journal: Cardiovascular research20080901

Title: Physiological effects of complexes of angiotensins with functionally different carrier proteins.

Journal: Bulletin of experimental biology and medicine20080801

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry20080724

Title: Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis.

Journal: American journal of physiology. Lung cellular and molecular physiology20080701

Title: Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid.

Journal: Prostaglandins, leukotrienes, and essential fatty acids20080601

Title: The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?

Journal: Vascular health and risk management20080601

Title: Angiotensin II- and glucose-stimulated extracellular matrix production: mediation by the insulin-like growth factor (IGF) axis in a murine mesangial cell line.

Journal: Endocrine20080201

Title: Importance and limits of ischemia in renal partial surgery: experimental and clinical research.

Journal: Advances in urology20080101

Title: Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling.

Journal: American journal of respiratory cell and molecular biology20071201

Title: Cardiovascular effects of centrally injected melittin in hemorrhaged hypotensive rats: the investigation of peripheral mechanisms.

Journal: Neuropeptides20071201

Title: Effect of angiotensin II receptor blocker on glucose-induced mRNA expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rat mesangial cells.

Journal: Chinese medical journal20071105

Title: The role of angiotensin II in the early stages of bovine ovulation.

Journal: Reproduction (Cambridge, England)20071101

Title: Interaction between endothelin and angiotensin II in the up-regulation of vasopressin messenger RNA in the inner medullary collecting duct of the rat.

Journal: Metabolism: clinical and experimental20071001

Title: Role of the brain renin-angiotensin system in blood pressure regulation.

Journal: Veterinary research communications20070801

Title: Role of the AT1A receptor in the CO2-induced stimulation of HCO3- reabsorption by renal proximal tubules.

Journal: American journal of physiology. Renal physiology20070701

Title: Cardiovascular response to renin substrate microinjection into the central nucleus of the amygdala of rats.

Journal: Neuroreport20070507

Title: Role of the vasodilator peptide angiotensin-(1-7) in cardiovascular drug therapy.

Journal: Vascular health and risk management20070201

Title: Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages.

Journal: Current pharmaceutical design20070101

Title: Regulation of cGMP synthesis in cultured podocytes by vasoactive hormones.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20061201

Title: Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060906

Title: Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid.

Journal: Life sciences20060501

Title: Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans.

Journal: Diabetologia20060201

Title: A non-radioactive method for angiotensin II receptor binding studies using the rat liver.

Journal: Journal of pharmacological and toxicological methods20060101

Title: Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.

Journal: Breast cancer research : BCR20060101

Title: Angiotensin II and III upregulate body fluid volume of the clam worm Perinereis sp. via angiotensin II receptors in different manners.

Journal: Peptides20051201

Title: Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblastsdagger.

Journal: Fundamental & clinical pharmacology20051201

Title: Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II.

Journal: The European journal of neuroscience20051001

Title: Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia.

Journal: British journal of cancer20050822

Title: Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20050601

Title: Angiotensin II receptor inhibition prevents pneumocyte apoptosis in surfactant-depleted rat lungs.

Journal: Pediatric pulmonology20050401

Title: Angiotensin II reverses the inhibitory action produced by theca cells on bovine oocyte nuclear maturation.

Journal: Theriogenology20050301

Title: Angiotensin II inhibition of Ca2+ currents is independent of ATR1 angiotensin II receptor activation in rat adult vagal afferent neurons.

Journal: Autonomic neuroscience : basic & clinical20050207

Title: A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception.

Journal: Neuroscience20050101

Title: Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors.

Journal: Circulation research20040625

Title: Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP20040301

Title: Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration.

Journal: Pediatric research20040201

Title: Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats.

Journal: Psychoneuroendocrinology20040101

Title: Stimulation of NHE3 in OKP cells by an autocrine mechanism.

Journal: Nephron. Experimental nephrology20040101

Title: Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs.

Journal: Critical care (London, England)20040101

Title: Intracoronary angiotensin II causes inotropic and vascular effects via different paracrine mechanisms.

Journal: Vascular pharmacology20040101

Title: Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response.

Journal: Regulatory peptides20031115

Title: Cardiac memory is associated with decreased levels of the transcriptional factor CREB modulated by angiotensin II and calcium.

Journal: Circulation research20030905

Title: Microinjection of renin-angiotensin system peptides in discrete sites within the rat periaqueductal gray matter elicits antinociception.

Journal: Brain research20030516

Title: Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin.

Journal: American journal of physiology. Heart and circulatory physiology20030401

Title: Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis.

Journal: Pancreas20030401

Title: Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats.

Journal: Journal of hypertension20030401

Title: Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area.

Journal: Arquivos brasileiros de cardiologia20030401

Title: Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis.

Journal: Regulatory peptides20030328

Title: Bleomycin-induced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novo.

Journal: American journal of physiology. Lung cellular and molecular physiology20030301

Title: Reduced dipsogenic response induced by angiotensin II activation of subfornical organ projections to the median preoptic nucleus in estrogen-treated rats.

Journal: Experimental neurology20030101

Title: The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.

Journal: Acta physiologica et pharmacologica Bulgarica20030101

Title: Angiotensin AT(1)-receptors depolarize neonatal spinal motoneurons and other ventral horn neurons via two different conductances.

Journal: Journal of neurophysiology20021101

Title: Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.

Journal: The Journal of pharmacology and experimental therapeutics20021001

Title: Angiotensin II vs its type I antagonists: conformational requirements for receptor binding assessed from NMR spectroscopic and receptor docking experiments.

Journal: Journal of medicinal chemistry20020926

Title: Alpha-adrenergic control of ANG II-induced drinking in the rat median preoptic nucleus.

Journal: Physiology & behavior20020901

Title: Involvement of the AT(2)-receptor in angiotensin II-induced facilitation of sympathetic neurotransmission.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS20020901

Title: Influence of ANG II on cytoplasmic sodium in cultured rabbit nonpigmented ciliary epithelium.

Journal: American journal of physiology. Cell physiology20020801

Title: Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP20020801

Title: Decreased monoamine release in the median preoptic area following ventricular treatment with the angiotensin II antagonist saralasin in normotensive and spontaneously hypertensive rats.

Journal: Regulatory peptides20020715

Title: The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake.

Journal: Methods and findings in experimental and clinical pharmacology20020601

Title: Attenuated drinking response induced by angiotensinergic activation of subfornical organ projections to the paraventricular nucleus in estrogen-treated rats.

Journal: Neuroscience letters20020524

Title: Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor.

Journal: Regulatory peptides20020115

Title: Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats.

Journal: The Journal of physiology20020101

Title: Effect of angiotensin II on ANP-dependent guanylyl cyclase activity in cultured mouse and rat podocytes.

Journal: Kidney & blood pressure research20020101

Title: Angiotensin II and the transcription factor Rel/NF-kappaB link environmental water shortage with memory improvement.

Journal: Neuroscience20020101

Title: Renal nuclear angiotensin II receptors in normal and hypertensive rats.

Journal: Acta physiologica Hungarica20020101

Title: Inhibition of the formation or action of angiotensin II reverses attenuated K+ currents in type 1 and type 2 diabetes.

Journal: The Journal of physiology20011115

Title: Estrogen decreases the responsiveness of subfornical organ neurons to angiotensinergic neural inputs from the lateral hypothalamic area in the female rat.

Journal: Experimental neurology20011001

Title: Inhibitory effect of the angiotensin converting enzyme inhibitors captopril and enalapril on the conversion of procollagen to collagen.

Journal: Journal of hypertension20011001

Title: Effects of central angiotensin II receptor antagonism on fetal swallowing and cardiovascular activity.

Journal: American journal of obstetrics and gynecology20011001

Title: [The cellular mechanism of angiotensin II inhibition on BKCa of ECV304 cell and the protective effect of gingko leaf extract].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae20011001

Title: Norepinephrine induces alveolar epithelial apoptosis mediated by alpha-, beta-, and angiotensin receptor activation.

Journal: American journal of physiology. Lung cellular and molecular physiology20010901

Title: Differentiation in the angiotensin II receptor 1 blocker class on autonomic function.

Journal: Current hypertension reports20010901

Title: Respiratory and metabolic effects of decreased osmolality in conscious rats.

Journal: Canadian journal of physiology and pharmacology20010901

Title: Cardiorespiratory effects of prolonged angiotensin II block in resting conscious dogs.

Journal: Canadian journal of physiology and pharmacology20010901

Title: Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS20010901

Title: Estrogen attenuates the drinking response induced by activation of angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in female rats.

Journal: Behavioural brain research20010701

Title: Angiotensin regulates endothelin-B receptor in rat inner medullary collecting duct.

Journal: Metabolism: clinical and experimental20010601

Title: Angiotensin II priming of aldosterone secretion with agents that enhance Ca(2+) influx.

Journal: Molecular and cellular endocrinology20010525

Title: Angiotensin II elicits water seeking behavior and the water absorption response in the toad Bufo bufo.

Journal: Hormones and behavior20010501

Title: Angiotensin receptor in the heart of Bothrops jararaca snake.

Journal: European journal of pharmacology20010406

Title: Activation of the subfornical organ enhances extracellular noradrenaline concentrations in the hypothalamic paraventricular nucleus in the rat.

Journal: Brain research bulletin20010301

Title: Angiotensin II type 1 receptor blockers.

Journal: Circulation20010213

Title: Role of angiotensin and its inhibition in hypertension, ischemic heart disease, and heart failure.

Journal: Hypertension (Dallas, Tex. : 1979)20010201

Title: Dipsogenic response induced by angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in rats.

Journal: Behavioural brain research20010129

Title: Angiotensinergic and noradrenergic mechanisms in the hypothalamic paraventricular nucleus participate in the drinking response induced by activation of the subfornical organ in rats.

Journal: Behavioural brain research20010129

Title: Angiotensin II increases neurogenic nitric oxide metabolism in mesenteric arteries from hypertensive rats.

Journal: Life sciences20010126

Title: Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle.

Journal: Pflugers Archiv : European journal of physiology20010101

Title: Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.

Journal: Proceedings of the National Academy of Sciences of the United States of America19961015

Title: Angiotensin II antagonists.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993)19931101

Title: Characterization of [3H]losartan receptors in isolated rat glomeruli.

Journal: European journal of pharmacology19931015

Title: Multiple binding modes for the receptor-bound conformations of cyclic AII agonists.

Journal: Journal of medicinal chemistry19930625

Title: Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells.

Journal: Regulatory peptides19930319

Title: Renin-angiotensin system stimulates respiration during acute hypotension but not during hypercapnia.

Journal: Journal of applied physiology (Bethesda, Md. : 1985)19930301

Title: Angiotensin in the brain suppresses epinephrine-induced cardiac arrhythmias through CNS opioid mechanisms.

Journal: Life sciences19910101

Title: Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs.

Journal: Clinical and experimental hypertension. Part A, Theory and practice19910101

Title: Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Journal: The Journal of clinical investigation19901101

Title: Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.

Journal: Molecular pharmacology19900301

Title: Angiotensin II as a modulator of baroreceptor reflexes in the brainstem of conscious rats.

Journal: Hypertension (Dallas, Tex. : 1979)19900201

Title: Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome.

Journal: The Journal of clinical investigation19830101

Title: Addition of acebutolol to diuretics in hypertension.

Journal: Clinical pharmacology and therapeutics19811201

Title: Etiopathogenesis of excess methylprednisolone arterial hypertension in the rat.

Journal: Clinical and experimental hypertension19810101

Title: Role of the anteroventral third ventricle region and the renin angiotensin system in methylprednisolone hypertension.

Journal: Hypertension (Dallas, Tex. : 1979)19810101

Title: Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats.

Journal: Anesthesiology19800201

Title: Effect of Sar1-ala8-angiotensin II on blood pressure and renin in Bartter's syndrome, before and after treatment with prostaglandin synthetase inhibitors.

Journal: Scandinavian journal of clinical and laboratory investigation19791001

Title: Dopamine and saralasin antagonism of renal vasoconstriction and oliguria caused by amphotericin B in dogs.

Journal: The Journal of infectious diseases19791001

Title: Severe hypotension before saralasin infusion.

Journal: Lancet (London, England)19790707

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