Home Other Building Blocks 3471-05-4
3471-05-4,MFCD01740555
Catalog No.:AA00C9JL

3471-05-4 | anabaseine

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10mg
4 weeks  
$277.00   $194.00
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100mg
3 weeks  
$385.00   $269.00
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250mg
3 weeks  
$466.00   $326.00
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1g
3 weeks  
$1,130.00   $791.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C9JL
Chemical Name:
anabaseine
CAS Number:
3471-05-4
Molecular Formula:
C10H14Cl2N2
Molecular Weight:
233.1376
MDL Number:
MFCD01740555
SMILES:
c1ccc(cn1)C1=NCCCC1.Cl.Cl
Properties
Computed Properties
 
Complexity:
175  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1  

Literature

Title: Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor.

Journal: The Journal of biological chemistry 20120622

Title: Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related α7 selective ligands.

Journal: European journal of medicinal chemistry 20111101

Title: Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

Journal: Journal of medicinal chemistry 20100624

Title: A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein.

Journal: European journal of medicinal chemistry 20100601

Title: Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.

Journal: The EMBO journal 20091007

Title: Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors.

Journal: British journal of pharmacology 20090501

Title: The effect of the cholinergic anti-inflammatory pathway on experimental colitis.

Journal: Scandinavian journal of immunology 20071101

Title: Complete assignments 1H and 13C NMR spectral data of four anabaseine derivatives.

Journal: Magnetic resonance in chemistry : MRC 20061201

Title: Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions.

Journal: Biochemistry 20060725

Title: N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine.

Journal: Neurotoxicology and teratology 20060101

Title: The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.

Journal: Molecular pharmacology 20040701

Title: [Sensitive nonradioactive screening method for compounds interacting with alpha7-cholinoreceptor].

Journal: Bioorganicheskaia khimiia 20030101

Title: Structure-activity relationships of benzylidene anabaseines in nicotinic acetylcholine receptors of cockroach nerve cords.

Journal: Bioorganic & medicinal chemistry 20020901

Title: Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20011201

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