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350992-13-1,MFCD09840052
Catalog No.:AA00C9HX

350992-13-1 | BIFEPRUNOX MESYLATE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$49.00   $34.00
- +
5mg
≥98%
in stock  
$132.00   $92.00
- +
10mg
≥98%
in stock  
$215.00   $150.00
- +
50mg
98%
in stock  
$529.00   $370.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C9HX
Chemical Name:
BIFEPRUNOX MESYLATE
CAS Number:
350992-13-1
Molecular Formula:
C25H27N3O5S
Molecular Weight:
481.5640
MDL Number:
MFCD09840052
SMILES:
CS(=O)(=O)O.O=c1[nH]c2c(o1)c(ccc2)N1CCN(CC1)Cc1cccc(c1)c1ccccc1
Properties
Properties
 
Form:
Solid  
MP:
>252ºC (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
649  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences nicotine-seeking behaviour in response to drug-associated stimuli in rats.

Journal: Addiction biology 20120301

Title: Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Journal: Journal of medicinal chemistry 20110714

Title: Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.

Journal: Behavioural brain research 20091105

Title: Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation.

Journal: Neuroscience letters 20090821

Title: Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour.

Journal: Journal of psychopharmacology (Oxford, England) 20090301

Title: Dopamine D2(High) receptors moderately elevated by bifeprunox and aripiprazole.

Journal: Synapse (New York, N.Y.) 20081201

Title: Efficacy and safety of bifeprunox in patients with an acute exacerbation of schizophrenia: results from a randomized, double-blind, placebo-controlled, multicenter, dose-finding study.

Journal: Psychopharmacology 20081001

Title: The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063.

Journal: European journal of pharmacology 20080911

Title: Differences in agonist/antagonist properties at human dopamine D(2) receptors between aripiprazole, bifeprunox and SDZ 208-912.

Journal: European journal of pharmacology 20071128

Title: Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation.

Journal: Journal of neurochemistry 20070801

Title: Neuropharmacological profile of bifeprunox: merits and limitations in comparison with other third-generation antipsychotics.

Journal: Current opinion in investigational drugs (London, England : 2000) 20070701

Title: Discriminative stimulus properties of S32504, a novel D3/D2 receptor agonist and antiparkinson agent, in rats: attenuation by the antipsychotics, aripiprazole, bifeprunox, N-desmethylclozapine, and by selective antagonists at dopamine D2 but not D3 receptors.

Journal: Psychopharmacology 20070401

Title: Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.

Journal: European journal of pharmacology 20060327

Title: Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Molecule of the month. Bifeprunox mesilate.

Journal: Drug news & perspectives 20051001

Title: Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in rats.

Journal: Neuropharmacology 20050801

Title: DU-127090 Solvay/H Lundbeck.

Journal: Current opinion in investigational drugs (London, England : 2000) 20030101

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