Title: Hypoglycemic effect of deoxynojirimycin-polysaccharide on high fat diet and streptozotocin-induced diabetic mice via regulation of hepatic glucose metabolism.
Journal: Chemico-biological interactions 20150105
Title: 1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20150101
Title: Medium-chain dehydrogenases with new specificity: amino mannitol dehydrogenases on the azasugar biosynthetic pathway.
Journal: Protein and peptide letters 20140101
Title: Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Journal: Nature structural & molecular biology 20130701
Title: Miglustat-induced intestinal carbohydrate malabsorption is due to the inhibition of α-glucosidases, but not β-galactosidases.
Journal: Journal of inherited metabolic disease 20121101
Title: Oxidative stress in Niemann-Pick type C patients: a protective role of N-butyl-deoxynojirimycin therapy.
Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20121001
Title: Initiation and discontinuation of substrate inhibitor treatment in patients with Niemann-Pick type C disease.
Journal: Gene 20120910
Title: Treatable metabolic psychoses that go undetected: what Niemann-Pick type C can teach us.
Journal: International journal of psychiatry in clinical practice 20120901
Title: Miglustat as a therapeutic agent: prospects and caveats.
Journal: Journal of medical genetics 20120901
Title: Intestinal alpha-glucosidase inhibitors: abdominal gas cysts.
Journal: Prescrire international 20120901
Title: α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants.
Journal: The Journal of biological chemistry 20120817
Title: Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120723
Title: Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection.
Journal: Journal of medicinal chemistry 20120712
Title: Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation.
Journal: Diabetes & vascular disease research 20120701
Title: Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50.
Journal: Diabetes technology & therapeutics 20120701
Title: Early miglustat therapy in infantile Niemann-Pick disease type C.
Journal: Pediatric neurology 20120701
Title: Deoxygenative olefination reaction as the key step in the syntheses of deoxy and iminosugars.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120618
Title: Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin.
Journal: Acta diabetologica 20120601
Title: Unexpected cure from cutaneous leukocytoclastic vasculitis in a patient treated with N-butyldeoxynojirimycin (miglustat) for Gaucher disease.
Journal: Advances in medical sciences 20120601
Title: Potent α-glucosidase inhibitors from safflower (Carthamus tinctorius L.) seed.
Journal: Phytotherapy research : PTR 20120501
Title: Synergy between the pharmacological chaperone 1-deoxygalactonojirimycin and the human recombinant alpha-galactosidase A in cultured fibroblasts from patients with Fabry disease.
Journal: Journal of inherited metabolic disease 20120501
Title: A randomized placebo-controlled trial of miglustat in cystic fibrosis based on nasal potential difference.
Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20120501
Title: Effect of miglitol as an add-on to bolus insulin on postprandial glycemic excursions in type 2 diabetes patients assessed by continuous glucose monitoring.
Journal: Diabetes technology & therapeutics 20120501
Title: Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C.
Journal: Journal of neuropathology and experimental neurology 20120501
Title: Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
Journal: Organic & biomolecular chemistry 20120421
Title: Eight stereoisomers of homonojirimycin from D-mannose.
Journal: Organic letters 20120420
Title: Anorexigenic effects of miglitol in concert with the alterations of gut hormone secretion and gastric emptying in healthy subjects.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120401
Title: Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients.
Journal: Diabetes, obesity & metabolism 20120301
Title: Substrate reduction therapy with miglustat for type 1 Gaucher disease: a retrospective analysis from a single institution.
Journal: Upsala journal of medical sciences 20120301
Title: Validated LC-MS/MS method for the quantitative determination of the glucosylceramide synthase inhibitor miglustat in mouse plasma and human plasma and its application to a pharmacokinetic study.
Journal: Journal of pharmaceutical and biomedical analysis 20120205
Title: Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats.
Journal: Die Pharmazie 20120201
Title: Extended remission of B-cell lymphoma with monoclonal gammopathy in a patient with type 1 Gaucher disease treated with enzyme replacement therapy.
Journal: Blood cells, molecules & diseases 20120115
Title: Crystal structure of human β-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases.
Journal: The Journal of biological chemistry 20120113
Title: Pharmacological chaperone therapy for Fabry disease.
Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20120111
Title: Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation.
Journal: Metabolism: clinical and experimental 20120101
Title: Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease.
Journal: The American journal of cardiology 20120101
Title: Solution and gas-phase H/D exchange of protein-small-molecule complexes: Cex and its inhibitors.
Journal: Journal of the American Society for Mass Spectrometry 20120101
Title: An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Effect of the α-glucosidase inhibitor miglitol on the glucose profile in Japanese type 2 diabetic patients receiving multiple daily insulin injections.
Journal: Endocrine journal 20120101
Title: Miglustat therapy in the French cohort of paediatric patients with Niemann-Pick disease type C.
Journal: Orphanet journal of rare diseases 20120101
Title: Successful treatment of reactive hypoglycemia secondary to late dumping syndrome using miglitol.
Journal: Internal medicine (Tokyo, Japan) 20120101
Title: Miglitol, an anti-diabetic drug, inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase.
Journal: Journal of pharmacological sciences 20120101
Title: [Affect of deoxynojirimycin derivatives on hepatitis C virus morphogenesis].
Journal: Molekuliarnaia biologiia 20120101
Title: The molecular basis of pharmacological chaperoning in human α-galactosidase.
Journal: Chemistry & biology 20111223
Title: Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors.
Journal: Carbohydrate research 20111213
Title: Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase.
Journal: Molecular pharmaceutics 20111205
Title: α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana.
Journal: Phytochemistry 20111201
Title: Gaucher disease due to saposin C deficiency, previously described as non-neuronopathic form--no positive effects after 2-years of miglustat therapy.
Journal: Molecular genetics and metabolism 20111201
Title: Endoplasmic reticulum stress induces autophagy through activation of p38 MAPK in fibroblasts from Pompe disease patients carrying c.546G>T mutation.
Journal: Molecular genetics and metabolism 20111201
Title: Murine β-galactosidase stability is not dependent on temperature or protective protein/cathepsin A.
Journal: Molecular genetics and metabolism 20111201
Title: Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes.
Journal: Metabolism: clinical and experimental 20111101
Title: Evaluation of miglustat treatment in patients with type III mucopolysaccharidosis: a randomized, double-blind, placebo-controlled study.
Journal: The Journal of pediatrics 20111101
Title: Canarene: a triterpenoid with a unique carbon skeleton from Canarium schweinfurthii.
Journal: Organic letters 20111021
Title: Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells.
Journal: The Journal of organic chemistry 20111007
Title: Modulators of sphingolipid metabolism reduce lung inflammation.
Journal: American journal of respiratory cell and molecular biology 20111001
Title: Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
Title: Gastrointestinal disturbances and their management in miglustat-treated patients.
Journal: Journal of inherited metabolic disease 20111001
Title: Fusion failure of dense-cored proacrosomal vesicles in an inducible mouse model of male infertility.
Journal: Cell and tissue research 20111001
Title: [Report of attendance at the Parseghian Scientific Conference for Niemann-Pick Type C (NP-C) Research, South Bend, Indiana: in search of new therapeutic possibilities for a very rare illness].
Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20111001
Title: Identification of a gene cluster that initiates azasugar biosynthesis in Bacillus amyloliquefaciens.
Journal: Chembiochem : a European journal of chemical biology 20110919
Title: 1-Deoxy-D-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines.
Journal: Carbohydrate research 20110906
Title: Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits.
Journal: British journal of pharmacology 20110901
Title: Iminosugars as therapeutic agents: recent advances and promising trends.
Journal: Future medicinal chemistry 20110901
Title: [Guidelines for type 1 Gaucher's disease].
Journal: Medicina clinica 20110901
Title: Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.
Journal: Organic & biomolecular chemistry 20110807
Title: A pharmacogenetic approach to identify mutant forms of α-galactosidase A that respond to a pharmacological chaperone for Fabry disease.
Journal: Human mutation 20110801
Title: [Correlation of DNJ between taxilli herba and its host-plants].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801
Title: Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110701
Title: Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.
Journal: Bioorganic & medicinal chemistry 20110701
Title: Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.
Journal: Organic & biomolecular chemistry 20110607
Title: Treatment of fabry disease: current and emerging strategies.
Journal: Current pharmaceutical biotechnology 20110601
Title: Identification of the genes involved in 1-deoxynojirimycin synthesis in Bacillus subtilis MORI 3K-85.
Journal: Journal of microbiology (Seoul, Korea) 20110601
Title: Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase.
Journal: Organic & biomolecular chemistry 20110521
Title: Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization.
Journal: The Journal of biological chemistry 20110513
Title: A general method for affinity-based proteomic profiling of exo-α-glycosidases.
Journal: Chemical communications (Cambridge, England) 20110507
Title: Targeting enteral endocrinal L-cells with dietary carbohydrates, by increasing the availability of miglitol in the intestinal lumen, leads to multi-fold enhancement of plasma glucagon-like peptide-1 levels in non-diabetic canines.
Journal: Drug development and industrial pharmacy 20110501
Title: Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: in vivo and in vitro studies.
Journal: Journal of agricultural and food chemistry 20110413
Title: Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.
Journal: Journal of ethnopharmacology 20110412
Title: Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the estimation of miglitol in human plasma using metformin as the internal standard.
Journal: Drug testing and analysis 20110401
Title: Efficacy of combined use of miglitol in Type 2 diabetes patients receiving insulin therapy-placebo-controlled double-blind comparative study.
Journal: Acta diabetologica 20110301
Title: Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas.
Journal: Acta diabetologica 20110301
Title: Comparing the efficacy of α-glucosidase inhibitors in suppressing postprandial hyperglycemia using continuous glucose monitoring: a pilot study-the MAJOR study.
Journal: Diabetes technology & therapeutics 20110301
Title: The videofluoroscopic swallowing study shows a sustained improvement of dysphagia in children with Niemann-Pick disease type C after therapy with miglustat.
Journal: American journal of medical genetics. Part A 20110301
Title: Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol.
Journal: Clinical and experimental nephrology 20110201
Title: Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease.
Journal: Journal of biochemistry 20110201
Title: Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study.
Journal: Neurology 20110125
Title: Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold.
Journal: Bioorganic & medicinal chemistry letters 20110115
Title: Treatment of cataplexy in Niemann-Pick disease type C with the use of miglustat.
Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20110101
Title: Effects of miglitol in combination with intensive insulin therapy on blood glucose control with special reference to incretin responses in type 1 diabetes mellitus.
Journal: Endocrine journal 20110101
Title: Glycosphingolipids and insulin resistance.
Journal: Advances in experimental medicine and biology 20110101
Title: Therapy of Fabry disease with pharmacological chaperones: from in silico predictions to in vitro tests.
Journal: Orphanet journal of rare diseases 20110101
Title: Effect of environmental conditions on the α-glucosidase inhibitory activity of mulberry leaves.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: Corneal alterations during combined therapy with cyclodextrin/allopregnanolone and miglustat in a knock-out mouse model of NPC1 disease.
Journal: PloS one 20110101
Title: A pilot study of the efficacy of miglitol and sitagliptin for type 2 diabetes with a continuous glucose monitoring system and incretin-related markers.
Journal: Cardiovascular diabetology 20110101
Title: Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S.
Journal: The Journal of biological chemistry 20101231
Title: N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Synthesis of all-cis 2,5-imino-2,5-dideoxy-fucitol and its evaluation as a potent fucosidase and galactosidase inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Syntheses of the enantiomers of 1-deoxynojirimycin and 1-deoxyaltronojirimycin via chemo- and diastereoselective olefinic oxidation of unsaturated amines.
Journal: The Journal of organic chemistry 20101203
Title: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus.
Journal: Metabolism: clinical and experimental 20101201
Title: The pathophysiology of GD - current understanding and rationale for existing and emerging therapeutic approaches.
Journal: Wiener medizinische Wochenschrift (1946) 20101201
Title: A Fluorescent sp2-iminosugar with pharmacological chaperone activity for gaucher disease: synthesis and intracellular distribution studies.
Journal: Chembiochem : a European journal of chemical biology 20101122
Title: Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.
Journal: Bioorganic & medicinal chemistry 20101115
Title: Molecular characterization of plant acidic alpha-mannosidase, a member of glycosylhydrolase family 38, involved in the turnover of N-glycans during tomato fruit ripening.
Journal: Journal of biochemistry 20101101
Title: Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.
Journal: Bioorganic & medicinal chemistry 20101101
Title: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol.
Journal: Metabolism: clinical and experimental 20101001
Title: Novel method for chase analysis of oligosaccharide metabolic error caused by xenobiotics.
Journal: Analytical biochemistry 20101001
Title: Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks.
Journal: Hepatology (Baltimore, Md.) 20101001
Title: Enantioselective and protecting group-free synthesis of 1-deoxythionojirimycin, 1-deoxythiomannojirimycin, and 1-deoxythiotalonojirimycin.
Journal: The Journal of organic chemistry 20101001
Title: Amplification of the inhibitory activity and reversal of the selectivity of miglitol by C(2')-monofluorination.
Journal: Archiv der Pharmazie 20101001
Title: Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry.
Journal: Analytical biochemistry 20100915
Title: Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.
Journal: Organic letters 20100903
Title: A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibition.
Journal: Glycobiology 20100901
Title: Deoxynojirimycin and its hexosaminyl derivatives bind to natural killer cell receptors rNKR-P1A and hCD69.
Journal: Bioorganic & medicinal chemistry letters 20100801
Title: How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane.
Journal: IUBMB life 20100801
Title: C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.
Journal: The Journal of biological chemistry 20100716
Title: 1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines.
Journal: Carbohydrate research 20100702
Title: DLHex-DGJ, a novel derivative of 1-deoxygalactonojirimycin with pharmacological chaperone activity in human G(M1)-gangliosidosis fibroblasts.
Journal: Molecular genetics and metabolism 20100701
Title: Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease - Juntendo University trial: effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (J-MACH) -.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20100701
Title: Comparison of absorption of 1-deoxynojirimycin from mulberry water extract in rats.
Journal: Journal of agricultural and food chemistry 20100609
Title: Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice.
Journal: Journal of neurochemistry 20100601
Title: Biological study of the angiogenesis inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin.
Journal: Chemical biology & drug design 20100601
Title: [Clinical diagnosis of the adult form of Niemann-Pick type C disease].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601
Title: [Therapies in the Niemann-Pick type C disease].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601
Title: Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20100501
Title: Purification and identification of 1-deoxynojirimycin (DNJ) in okara fermented by Bacillus subtilis B2 from Chinese traditional food (Meitaoza).
Journal: Journal of agricultural and food chemistry 20100414
Title: Changes in the atherogenic profile of patients with type 1 Gaucher disease after miglustat therapy.
Journal: Atherosclerosis 20100401
Title: Miglustat in adult and juvenile patients with Niemann-Pick disease type C: long-term data from a clinical trial.
Journal: Molecular genetics and metabolism 20100401
Title: Entamoeba histolytica: identification and partial characterization of alpha-mannosidase activity.
Journal: Experimental parasitology 20100401
Title: Clinical experience with miglustat therapy in pediatric patients with Niemann-Pick disease type C: a case series.
Journal: Molecular genetics and metabolism 20100401
Title: A case of insulinoma following total gastrectomy--effects of an alpha-glucosidase inhibitor on suppressing GIP and GLP-1 elevations.
Journal: Diabetes research and clinical practice 20100401
Title: Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells.
Journal: Glycoconjugate journal 20100401
Title: Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.
Journal: Journal of Zhejiang University. Science. B 20100401
Title: Simple, selective, and rapid quantification of 1-deoxynojirimycin in mulberry leaf products by high-performance anion-exchange chromatography with pulsed amperometric detection.
Journal: Journal of food science 20100401
Title: Short and straightforward synthesis of (-)-1-deoxygalactonojirimycin.
Journal: Organic letters 20100319
Title: Long-term miglustat therapy in children with Niemann-Pick disease type C.
Journal: Journal of child neurology 20100301
Title: Eye movement and diffusion tensor imaging analysis of treatment effects in a Niemann-Pick Type C patient.
Journal: Molecular genetics and metabolism 20100301
Title: Glucose supply and insulin demand dynamics of antidiabetic agents.
Journal: Journal of diabetes science and technology 20100301
Title: Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100301
Title: Force majeure: therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease.
Journal: Blood cells, molecules & diseases 20100115
Title: The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20100101
Title: An oxidation and ring contraction approach to the synthesis of (+/-)-1-deoxynojirimycin and (+/-)-1-deoxyaltronojirimycin.
Journal: Organic letters 20100101
Title: Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range.
Journal: Angewandte Chemie (International ed. in English) 20100101
Title: Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men.
Journal: Endocrine journal 20100101
Title: Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men.
Journal: Endocrine journal 20100101
Title: Niemann-Pick disease type C.
Journal: Orphanet journal of rare diseases 20100101
Title: Comparison of adverse gastrointestinal effects of acarbose and miglitol in healthy men: a crossover study.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: Oxidative stress in Niemann-Pick disease, type C.
Journal: Molecular genetics and metabolism 20100101
Title: Pneumatosis cystoides intestinalis induced by the α-glucosidase inhibitor miglitol.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: Prediction of the responsiveness to pharmacological chaperones: lysosomal human alpha-galactosidase, a case of study.
Journal: Orphanet journal of rare diseases 20100101
Title: Reduced expression of β2 integrin genes in rat peripheral leukocytes by inhibiting postprandial hyperglycemia.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Silkworm pupae (Bombyx mori) are new sources of high quality protein and lipid.
Journal: Journal of nutritional science and vitaminology 20100101
Title: The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats.
Journal: European journal of pharmacology 20091210
Title: Real-world clinical experience with long-term miglustat maintenance therapy in type 1 Gaucher disease: the ZAGAL project.
Journal: Haematologica 20091201
Title: The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase.
Journal: Human mutation 20091201
Title: Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.
Journal: The FEBS journal 20091201
Title: Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology.
Journal: Bioscience, biotechnology, and biochemistry 20091201
Title: [Treatment of bone involvement in Gaucher diseases with imiglucerase combined with miglustat].
Journal: Presse medicale (Paris, France : 1983) 20091201
Title: Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver.
Journal: Journal of agricultural and food chemistry 20091125
Title: Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin.
Journal: Chembiochem : a European journal of chemical biology 20091123
Title: Miglustat in patients with Niemann-Pick disease Type C (NP-C): a multicenter observational retrospective cohort study.
Journal: Molecular genetics and metabolism 20091101
Title: Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.
Journal: Hepatology (Baltimore, Md.) 20091101
Title: Phytochemical profiles of different mulberry (Morus sp.) species from China.
Journal: Journal of agricultural and food chemistry 20091014
Title: Design and evaluation of oral bioadhesive controlled release formulations of miglitol, intended for prolonged inhibition of intestinal alpha-glucosidases and enhancement of plasma glucagon like peptide-1 levels.
Journal: International journal of pharmaceutics 20091001
Title: Amplification of the inhibitory activity of miglitol by monofluorination.
Journal: Bioorganic & medicinal chemistry letters 20091001
Title: Miglustat (Zavesca) in type 1 Gaucher disease: 5-year results of a post-authorisation safety surveillance programme.
Journal: Pharmacoepidemiology and drug safety 20090901
Title: Synthesis of polyfunctional quinolizidine alkaloids: development towards selective glycosidase inhibitors.
Journal: Organic & biomolecular chemistry 20090821
Title: Raffinose and stachyose metabolism are not required for efficient soybean seed germination.
Journal: Journal of plant physiology 20090815
Title: A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.
Journal: American journal of respiratory cell and molecular biology 20090801
Title: Pharmacokinetics, safety and tolerability of miglustat in the treatment of pediatric patients with GM2 gangliosidosis.
Journal: Molecular genetics and metabolism 20090801
Title: Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase.
Journal: Analytical and bioanalytical chemistry 20090801
Title: The alpha-glucosidase inhibitor miglitol suppresses postprandial hyperglycaemia and interleukin-1beta and tumour necrosis factor-alpha gene expression in rat peripheral leucocytes induced by intermittent sucrose loading.
Journal: The British journal of nutrition 20090701
Title: Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase.
Journal: Biological chemistry 20090701
Title: Structural determinants of product specificity of sucrose isomerases.
Journal: FEBS letters 20090618
Title: 6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.
Journal: Chembiochem : a European journal of chemical biology 20090615
Title: Organocatalytic syn-aldol reactions of dioxanones with (S)-isoserinal hydrate: synthesis of L-deoxymannojirimycin and L-deoxyidonojirimycin.
Journal: The Journal of organic chemistry 20090605
Title: The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes.
Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20090601
Title: The pharmacological chaperone N-butyldeoxynojirimycin enhances enzyme replacement therapy in Pompe disease fibroblasts.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20090601
Title: Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice.
Journal: American journal of respiratory and critical care medicine 20090601
Title: Miglustat in late-onset Tay-Sachs disease: a 12-month, randomized, controlled clinical study with 24 months of extended treatment.
Journal: Genetics in medicine : official journal of the American College of Medical Genetics 20090601
Title: The pharmacological chaperone 1-deoxygalactonojirimycin increases alpha-galactosidase A levels in Fabry patient cell lines.
Journal: Journal of inherited metabolic disease 20090601
Title: A stereocontrolled synthesis of 3-acetamido-1,3,5-trideoxy- and 1,3,5,6-tetradeoxy-1,5-imino-D-glucitol.
Journal: Carbohydrate research 20090526
Title: Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity.
Journal: European journal of pharmacology 20090501
Title: Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.
Journal: Chembiochem : a European journal of chemical biology 20090417
Title: [Recent therapeutics for Fabry disease].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090410
Title: Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease.
Journal: Molecular genetics and metabolism 20090401
Title: Expeditious synthesis of a common intermediate of L-1-deoxyallonojirimycin and L-1-deoxymannojirimycin.
Journal: The Journal of organic chemistry 20090306
Title: Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090301
Title: Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease.
Journal: The Journal of pharmacology and experimental therapeutics 20090301
Title: [Quantitative determination of 1-deoxynojirimycin in mulberry leaves by high-performance liquid chromatographic-tandem mass/mass spectrometry].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090301
Title: A short and convenient synthesis of 1-deoxymannojirimycin and N-oxy analogues from D-fructose.
Journal: The Journal of organic chemistry 20090220
Title: Deoxynojirimycin enhanced the transglycosylation activity of a glycosidase from the China white jade snail.
Journal: Journal of biotechnology 20090205
Title: 24 month-treatment with miglustat of three patients with Niemann-Pick disease type C: follow up using brain spectroscopy.
Journal: Molecular genetics and metabolism 20090201
Title: Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.
Journal: Hepatology (Baltimore, Md.) 20090201
Title: Miglitol induces prolonged and enhanced glucagon-like peptide-1 and reduced gastric inhibitory polypeptide responses after ingestion of a mixed meal in Japanese Type 2 diabetic patients.
Journal: Diabetic medicine : a journal of the British Diabetic Association 20090201
Title: [Chemical constituents from Polygala telephioides].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201
Title: [Study on changes of contents of 1-deoxynojirimycin in Bombyx mori and their byproducts].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090201
Title: Effects of a chemical chaperone on genetic mutations in alpha-galactosidase A in Korean patients with Fabry disease.
Journal: Experimental & molecular medicine 20090131
Title: Multivalent iminosugars to modulate affinity and selectivity for glycosidases.
Journal: Organic & biomolecular chemistry 20090121
Title: Rapid quantification of miglustat in human plasma and cerebrospinal fluid by liquid chromatography coupled with tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115
Title: Effect of insulin-unstimulated diabetic therapy with miglitol on serum cystatin C level and its clinical significance.
Journal: Diabetes research and clinical practice 20090101
Title: Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death.
Journal: Neurotoxicology 20090101
Title: Class II alpha-mannosidase from Aspergillus fischeri: energetics of catalysis and inhibition.
Journal: International journal of biological macromolecules 20090101
Title: Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease.
Journal: Blood cells, molecules & diseases 20090101
Title: Goal-oriented therapy with miglustat in Gaucher disease.
Journal: Current medical research and opinion 20090101
Title: Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.
Journal: PloS one 20090101
Title: Substrate reduction therapy in juvenile GM2 gangliosidosis.
Journal: Molecular genetics and metabolism 20090101
Title: Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression.
Journal: PloS one 20090101
Title: Pharmacological chaperone therapy by active-site-specific chaperones in Fabry disease: in vitro and preclinical studies.
Journal: International journal of clinical pharmacology and therapeutics 20090101
Title: 1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors.
Journal: Bioorganic & medicinal chemistry 20081215
Title: Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel.
Journal: Hepatology (Baltimore, Md.) 20081201
Title: Treatment of a child diagnosed with Niemann-Pick disease type C with miglustat: a case report in Brazil.
Journal: Journal of inherited metabolic disease 20081201
Title: Synthesis of iminoalditol analogues of galactofuranosides and their activities against glycosidases.
Journal: Carbohydrate research 20081124
Title: Anti-inflammatory effect of miglustat in bronchial epithelial cells.
Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20081101
Title: Randomized, controlled trial of miglustat in Gaucher's disease type 3.
Journal: Annals of neurology 20081101
Title: Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.
Journal: Journal of neuroimmunology 20081015
Title: Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors.
Journal: Journal of medicinal chemistry 20081009
Title: Novel anti-adherence activity of mulberry leaves: inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba.
Journal: The Journal of antimicrobial chemotherapy 20081001
Title: N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
Journal: AIDS (London, England) 20081001
Title: New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition.
Journal: Organic letters 20080904
Title: The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.
Journal: The Journal of pharmacology and experimental therapeutics 20080901
Title: Prediction of response of mutated alpha-galactosidase A to a pharmacological chaperone.
Journal: Pharmacogenetics and genomics 20080901
Title: Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects.
Journal: Metabolism: clinical and experimental 20080901
Title: Comparison of pre- vs. postmeal administration of miglitol for 3 months in type 2 diabetic patients.
Journal: Diabetes, obesity & metabolism 20080901
Title: [Determination of 1-deoxynojirimycin in Morus alba L. leaves using reversed-phase high performance liquid chromatography fluorescence detection with pre-column derivatization].
Journal: Se pu = Chinese journal of chromatography 20080901
Title: Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies.
Journal: Bioscience, biotechnology, and biochemistry 20080801
Title: Synthesis of somatostatin mimetics based on 1-deoxynojirimycin.
Journal: ChemMedChem 20080701
Title: Changes of bone metabolism in seven patients with Gaucher disease treated consecutively with imiglucerase and miglustat.
Journal: Calcified tissue international 20080701
Title: Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis.
Journal: Bioorganic & medicinal chemistry 20080615
Title: Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.
Journal: The Journal of pharmacology and experimental therapeutics 20080601
Title: Splenic nodules in paediatric Gaucher disease treated by enzyme replacement therapy.
Journal: Pediatric radiology 20080601
Title: Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes.
Journal: Biochimica et biophysica acta 20080601
Title: Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Journal: Molecular genetics and metabolism 20080601
Title: Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.
Journal: Pharmacogenomics 20080601
Title: Cell surface associated alpha-L-fucose moieties modulate human breast cancer neoplastic progression.
Journal: Pathology oncology research : POR 20080601
Title: Beta-fructofuranosidase genes of the silkworm, Bombyx mori: insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex.
Journal: The Journal of biological chemistry 20080530
Title: Regioselective intramolecular ring closure of 2-amino-6-bromo-2,6-dideoxyhexono-1,4-lactones to 5- or 6-membered iminuronic acid analogues: synthesis of 1-deoxymannojirimycin and 2,5-dideoxy-2,5-imino-D-glucitol.
Journal: Organic & biomolecular chemistry 20080521
Title: N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice.
Journal: Neurochemistry international 20080501
Title: Binding parameters and thermodynamics of the interaction of imino sugars with a recombinant human acid alpha-glucosidase (alglucosidase alfa): insight into the complex formation mechanism.
Journal: Clinica chimica acta; international journal of clinical chemistry 20080501
Title: Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models.
Journal: Journal of agricultural and food chemistry 20080423
Title: New building block for polyhydroxylated piperidine: total synthesis of 1,6-dideoxynojirimycin.
Journal: The Journal of organic chemistry 20080404
Title: Gaucher disease: improving management.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20080401
Title: Gaucher disease: unmet treatment needs.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20080401
Title: Substrate reduction therapy.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20080401
Title: Diastereoselective synthesis of piperidine imino sugars using aldol additions of metalated bislactim ethers to threose and erythrose acetonides.
Journal: The Journal of organic chemistry 20080321
Title: [New data on Gaucher's disease].
Journal: La Revue de medecine interne 20080301
Title: New perspectives in non-hormonal male contraception.
Journal: Trends in endocrinology and metabolism: TEM 20080301
Title: An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-gamma and IL-4.
Journal: Bioorganic & medicinal chemistry 20080215
Title: Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.
Journal: Cell calcium 20080201
Title: Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles.
Journal: Bioorganic & medicinal chemistry letters 20080201
Title: N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice.
Journal: Diabetes, obesity & metabolism 20080201
Title: The relationship between 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan.
Journal: Journal of natural medicines 20080101
Title: Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sensitive liposomes into HM3KO melanoma cells.
Journal: Journal of cosmetic science 20080101
Title: [Contrast of 1-deoxynojirimycin content in mulberry leaves from different habitats].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101
Title: [Osteoarticular manifestations of Gaucher disease in adults: pathophysiology and treatment].
Journal: Presse medicale (Paris, France : 1983) 20071201
Title: [Niemann-Pick diseases in adults].
Journal: La Revue de medecine interne 20071201
Title: Divided-dose administration of miglitol just before and 15 minutes after the start of a meal smoothes postprandial plasma glucose excursions and serum insulin responses in healthy men.
Journal: Endocrine journal 20071201
Title: [In-vitro study of the drug interactions between Miglitol, an alpha-glucosidase inhibitor, and adsorbents].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071201
Title: Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.
Journal: The Journal of biological chemistry 20071109
Title: Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus.
Journal: Metabolism: clinical and experimental 20071101
Title: [Alkaloid constituents from silkworm dropping of Bombyx mori].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071101
Title: Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma.
Journal: Journal of agricultural and food chemistry 20071031
Title: [Adverse effects of alpha-glucosidase inhibitors].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028
Title: Administration of miglitol until 30 min after the start of a meal is effective in type 2 diabetic patients.
Journal: Diabetes research and clinical practice 20071001
Title: Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats.
Journal: The British journal of nutrition 20071001
Title: Treatment of Niemann-Pick disease type C in two children with miglustat: initial responses and maintenance of effects over 1 year.
Journal: Journal of inherited metabolic disease 20071001
Title: Oral maintenance clinical trial with miglustat for type I Gaucher disease: switch from or combination with intravenous enzyme replacement.
Journal: Blood 20071001
Title: Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase.
Journal: Journal of clinical pharmacology 20071001
Title: Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins.
Journal: Journal of microbiology (Seoul, Korea) 20071001
Title: [Therapeutic objectives in Gaucher disease].
Journal: La Revue de medecine interne 20071001
Title: [Osteoarticular manifestations of Gaucher disease in adults: pathophysiology and treatment].
Journal: La Revue de medecine interne 20071001
Title: [Current development and usefulness of biomarkers for Gaucher disease follow up].
Journal: La Revue de medecine interne 20071001
Title: [Organization of Gaucher disease management in France].
Journal: La Revue de medecine interne 20071001
Title: Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
Journal: The Journal of biological chemistry 20070928
Title: Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human beta-glucocerebrosidase.
Journal: Carbohydrate research 20070903
Title: Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugars.
Journal: Carbohydrate research 20070903
Title: Synthesis and NMR experiments of (4,5,6-13C)-deoxymannojirimycin. A new entry to 13C-labeled glycosidase inhibitors.
Journal: Carbohydrate research 20070903
Title: Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin.
Journal: The Biochemical journal 20070901
Title: Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study.
Journal: The Lancet. Neurology 20070901
Title: Alpha-glucosidase inhibitors from Millettia conraui.
Journal: Chemical & pharmaceutical bulletin 20070901
Title: Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20070815
Title: Effective treatment of an elderly patient with Gaucher's disease and Parkinsonism: a case report of 24 months' oral substrate reduction therapy with miglustat.
Journal: Parkinsonism & related disorders 20070801
Title: Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies.
Journal: Clinical therapeutics 20070801
Title: Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans.
Journal: Journal of agricultural and food chemistry 20070711
Title: Neurologic improvement in a type 3 Gaucher disease patient treated with imiglucerase/miglustat combination.
Journal: Epilepsia 20070701
Title: Mouse sperm rosette: assembling during epididymal transit, in vitro disassemble, and oligosaccharide participation in the linkage material.
Journal: Anatomical record (Hoboken, N.J. : 2007) 20070701
Title: [Molecular pathogenesis and therapeutic targets of lysosomal diseases].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20070701
Title: N-azidoacetylmannosamine-mediated chemical tagging of gangliosides.
Journal: Journal of lipid research 20070601
Title: Differential alteration of lipid antigen presentation to NKT cells due to imbalances in lipid metabolism.
Journal: European journal of immunology 20070601
Title: Evaluation of the efficacy, safety and tolerability of miglitol in adult Indian patients with uncomplicated type 2 diabetes mellitus.
Journal: Journal of the Indian Medical Association 20070601
Title: The alpha(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120.
Journal: FEBS letters 20070515
Title: Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase.
Journal: Biochemical pharmacology 20070501
Title: Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.
Journal: Diabetes 20070501
Title: Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
Journal: Nature medicine 20070401
Title: Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors.
Journal: The Journal of general virology 20070401
Title: [Chemical constituents from leaves of Morus multicaulis].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401
Title: Miglustat has no apparent effect on spermatogenesis in normal men.
Journal: Human reproduction (Oxford, England) 20070301
Title: A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.
Journal: The Journal of infectious diseases 20070301
Title: [Is it possible to treat the brain? Recent advances in inherited neurodegenerative disorders].
Journal: No to hattatsu = Brain and development 20070301
Title: The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070301
Title: Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.
Journal: The Journal of organic chemistry 20070216
Title: Detection of weak sugar binding activity of VIP36 using VIP36-streptavidin complex and membrane-based sugar chains.
Journal: Journal of biochemistry 20070201
Title: Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment.
Journal: Journal of inherited metabolic disease 20070201
Title: Chemical chaperones improve transport and enhance stability of mutant alpha-glucosidases in glycogen storage disease type II.
Journal: Molecular genetics and metabolism 20070101
Title: Determination of miglitol in human plasma by liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study.
Journal: Reproductive biology and endocrinology : RB&E 20070101
Title: [Cost reduction in the treatment of Gaucher s disease].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101
Title: Substrate deprivation therapy: a new hope for patients suffering from neuronopathic forms of inherited lysosomal storage diseases.
Journal: Journal of applied genetics 20070101
Title: Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes.
Journal: Glycobiology 20061201
Title: Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.
Journal: Bioorganic & medicinal chemistry 20061201
Title: Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins.
Journal: Cryobiology 20061201
Title: Cellobiase from Termitomyces clypeatus: activity and secretion in presence of glycosylation inhibitors.
Journal: Biotechnology letters 20061101
Title: Convergent approach toward the synthesis of the stereoisomers of C-6 homologues of 1-deoxynojirimycin and their analogues: evaluation as specific glycosidase inhibitors.
Journal: The Journal of organic chemistry 20061027
Title: Polyhydroxylated homoazepanes and 1-deoxy-homonojirimycin analogues: Synthesis and glycosidase inhibition study.
Journal: Organic & biomolecular chemistry 20061007
Title: A facile synthesis of 1,6-dideoxynojirimycin from L-sorbose.
Journal: Carbohydrate research 20060925
Title: 1,3-Dideoxynojirimycin-3-yl glycosides of beta-(1-->3)- and beta-(1-->6)-linked gluco-oligosaccharides.
Journal: Carbohydrate research 20060904
Title: Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease.
Journal: Chembiochem : a European journal of chemical biology 20060901
Title: Synthesis and evaluation of glycosidase inhibitory activity of N-butyl 1-deoxy-D-gluco-homonojirimycin and N-butyl 1-deoxy-L-ido-homonojirimycin.
Journal: Bioorganic & medicinal chemistry 20060815
Title: exo-Imino to endo-iminocyclitol rearrangement. A general route to five-membered antiviral azasugars.
Journal: Organic letters 20060803
Title: Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway.
Journal: Glycobiology 20060801
Title: Reduced inflammatory potential of peritoneal macrophages recruited in mice pretreated with a glycolipid synthesis inhibitor.
Journal: Inflammopharmacology 20060801
Title: 1-Deoxynojirimycin derivatives from the marine sponge Lendenfeldia chondrodes.
Journal: The Journal of antibiotics 20060801
Title: Gangliosides do not affect ABC transporter function in human neuroblastoma cells.
Journal: Journal of lipid research 20060601
Title: 1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721.
Journal: Biochemical and biophysical research communications 20060526
Title: Synthesis and biological evaluation of glycosidase inhibitors: gem-difluoromethylenated nojirimycin analogues.
Journal: Journal of medicinal chemistry 20060518
Title: Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives.
Journal: Biochemistry 20060509
Title: Nucleophilic opening of epoxyazepanes: expanding the family of polyhydroxyazepane-based glycosidase inhibitors.
Journal: Organic & biomolecular chemistry 20060507
Title: Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin.
Journal: Human reproduction (Oxford, England) 20060501
Title: Short-term effect of miglustat in every day clinical use in treatment-naïve or previously treated patients with type 1 Gaucher's disease.
Journal: Haematologica 20060501
Title: D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains.
Journal: Biochemistry 20060411
Title: Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat.
Journal: FEBS letters 20060403
Title: Pharmacological chaperone corrects lysosomal storage in Fabry disease caused by trafficking-incompetent variants.
Journal: American journal of physiology. Cell physiology 20060401
Title: Gaucher disease: multiple lessons from a single gene disorder.
Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement 20060401
Title: Asymmetric synthesis of the L-fuco-nojirimycin, a nanomolar alpha-L-fucosidase inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20060301
Title: Purification of soluble alpha1,2-mannosidase from Candida albicans CAI-4.
Journal: FEMS microbiology letters 20060301
Title: Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp.
Journal: Journal of natural products 20060301
Title: [Clinical study of the French cohort of Gaucher disease patients].
Journal: La Revue de medecine interne 20060301
Title: Therapeutic goals in Gaucher disease.
Journal: La Revue de medecine interne 20060301
Title: [Pharmacokinetic, pharmacological, and clinical profile of miglitol (SEIBULE), a novel alpha-glucosidase inhibitor].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060301
Title: Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors.
Journal: The Journal of organic chemistry 20060203
Title: Substrate reduction therapy in the infantile form of Tay-Sachs disease.
Journal: Neurology 20060124
Title: Miglustat: substrate reduction therapy for glycosphingolipid lysosomal storage disorders.
Journal: Drugs of today (Barcelona, Spain : 1998) 20060101
Title: Emerging strategies for the treatment of hereditary metabolic storage disorders.
Journal: Rejuvenation research 20060101
Title: Substrate reduction therapy of glycosphingolipid storage disorders.
Journal: Journal of inherited metabolic disease 20060101
Title: Liquid chromatographic tandem mass spectrometry method for the quantification of miglitol in human plasma.
Journal: Arzneimittel-Forschung 20060101
Title: alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins.
Journal: Antiviral chemistry & chemotherapy 20060101
Title: Miglustat: substrate reduction therapy for lysosomal storage disorders associated with primary central nervous system involvement.
Journal: Recent patents on CNS drug discovery 20060101
Title: Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin.
Journal: Carbohydrate research 20051230
Title: Binding residues and catalytic domain of soluble Saccharomyces cerevisiae processing alpha-glucosidase I.
Journal: Glycobiology 20051201
Title: Guidance on the use of miglustat for treating patients with type 1 Gaucher disease.
Journal: American journal of hematology 20051101
Title: A stereoselective route toward polyhydoxylated piperidines. A total synthesis of (+/-)-deoxymannojirimycin.
Journal: Organic letters 20051027
Title: Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold.
Journal: The Journal of organic chemistry 20051014
Title: The anti-diabetic drug miglitol is protective against anginal ischaemia through a mechanism independent of regional myocardial blood flow in the dog.
Journal: Clinical and experimental pharmacology & physiology 20051001
Title: Miglustat: new drug. In type 1 Gaucher's disease : a slight benefit after imiglucerase therapy.
Journal: Prescrire international 20051001
Title: An open-label, noncomparative study of miglustat in type I Gaucher disease: efficacy and tolerability over 24 months of treatment.
Journal: Clinical therapeutics 20050801
Title: Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator.
Journal: The Journal of biological chemistry 20050701
Title: Glucose trimming of N-glycan in endoplasmic reticulum is indispensable for the growth of Raphanus sativus seedling (kaiware radish).
Journal: Bioscience, biotechnology, and biochemistry 20050701
Title: Highly stereocontrolled synthesis of gem-difluoromethylenated azasugars: D- and L-1,4,6-trideoxy-4,4-difluoronojirimycin.
Journal: Organic letters 20050526
Title: [Determination of 1-deoxynojirimycin in leaves of Morus alba by high performance liquid chromatography with fluorescence detection].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501
Title: Alpha-glucosidase inhibitors for type 2 diabetes mellitus.
Journal: The Cochrane database of systematic reviews 20050418
Title: Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
Journal: Biology of reproduction 20050401
Title: Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice.
Journal: Journal of lipid research 20050401
Title: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1. Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter.
Journal: The FEBS journal 20050401
Title: Biological properties of D- and L-1-deoxyazasugars.
Journal: Journal of medicinal chemistry 20050324
Title: The synthesis of hybrids of D-galactose with 1-deoxynojirimycin analogues as glycosidase inhibitors.
Journal: Angewandte Chemie (International ed. in English) 20050318
Title: General approach to glycosidase inhibitors. Enantioselective synthesis of deoxymannojirimycin and swainsonine.
Journal: The Journal of organic chemistry 20050318
Title: General synthesis and biological evaluation of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides).
Journal: Bioorganic & medicinal chemistry 20050315
Title: Aglycon specificity profiling of alpha-glucosidases using synthetic probes.
Journal: Bioorganic & medicinal chemistry letters 20050301
Title: Substrate reduction therapy for lysosomal storage diseases.
Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement 20050301
Title: Computerized cognitive testing in patients with type I Gaucher disease: effects of enzyme replacement and substrate reduction.
Journal: Genetics in medicine : official journal of the American College of Medical Genetics 20050201
Title: A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050101
Title: A Madagascar Sponge Batzella sp. as a source of alkylated iminosugars.
Journal: Journal of natural products 20050101
Title: Miglustat (NB-DNJ) works as a chaperone for mutated acid beta-glucosidase in cells transfected with several Gaucher disease mutations.
Journal: Blood cells, molecules & diseases 20050101
Title: Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile.
Journal: Bioorganic & medicinal chemistry letters 20041220
Title: Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease.
Journal: Biochimica et biophysica acta 20041105
Title: NSAIDs increase survival in the Sandhoff disease mouse: synergy with N-butyldeoxynojirimycin.
Journal: Annals of neurology 20041101
Title: Therapy of Niemann-Pick disease, type C.
Journal: Biochimica et biophysica acta 20041011
Title: Synthesis of alkylated deoxynojirimycin and 1,5-dideoxy-1,5-iminoxylitol analogues: polar side-chain modification, sulfonium and selenonium heteroatom variants, conformational analysis, and evaluation as glycosidase inhibitors.
Journal: Journal of the American Chemical Society 20041006
Title: Biosynthesis of 1-deoxynojirimycin in Commelina communis: a difference between the microorganisms and plants.
Journal: Phytochemistry 20041001
Title: Conversion of the carbohydrate structures of glycoproteins in roots of Raphanus sativus using several glycosidase inhibitors.
Journal: Journal of biochemistry 20041001
Title: Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
Journal: The Journal of biological chemistry 20040924
Title: Inhibition of alpha-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life.
Journal: The Journal of biological chemistry 20040917
Title: Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.
Journal: Chemistry & biology 20040901
Title: Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A.
Journal: Chemical communications (Cambridge, England) 20040821
Title: Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
Journal: The Biochemical journal 20040801
Title: Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.
Journal: The Biochemical journal 20040801
Title: Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease.
Journal: Neurobiology of disease 20040801
Title: Specific inhibition effects of N-pentafluorobenzyl-1-deoxynojirimycin on human CD4+ T cells.
Journal: Bioorganic & medicinal chemistry letters 20040716
Title: Golgi endomannosidase inhibitor, alpha-D-glucopyranosyl-(1 --> 3)-1-deoxymannojirimycin: a five-step synthesis from maltulose and examples of N-modified derivatives.
Journal: Carbohydrate research 20040712
Title: Asymmetric dihydroxylation of d-glucose derived alpha,beta-unsaturated ester: synthesis of azepane and nojirimycin analogues.
Journal: The Journal of organic chemistry 20040709
Title: Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis.
Journal: International immunopharmacology 20040701
Title: Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart.
Journal: British journal of pharmacology 20040701
Title: Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport.
Journal: The Journal of biological chemistry 20040618
Title: Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats.
Journal: Journal of nutritional science and vitaminology 20040601
Title: A general synthesis of iminosugars.
Journal: The Journal of organic chemistry 20040514
Title: Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501
Title: Relations of the type and branch of surface N-glycans to cell adhesion, migration and integrin expressions.
Journal: Molecular and cellular biochemistry 20040501
Title: CD28 T cell costimulatory receptor function is negatively regulated by N-linked carbohydrates.
Journal: Biochemical and biophysical research communications 20040423
Title: Synthesis of 1-deoxy-D-galactohomonojirimycin via enantiomerically pure allenylstannanes.
Journal: The Journal of organic chemistry 20040402
Title: Synthesis of a novel photoaffinity derivative of 1-deoxynojirimycin for active site-directed labeling of glucosidase I.
Journal: Glycobiology 20040401
Title: Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.
Journal: Journal of agricultural and food chemistry 20040324
Title: Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.
Journal: Biochemical pharmacology 20040215
Title: An improved purification procedure for soluble processing alpha-glucosidase I from Saccharomyces cerevisiae overexpressing CWH41.
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Title: [Usefulness of miglitol in patients with diabetes mellitus type 2 and insufficient control of the blood glucose].
Journal: Revista clinica espanola 20040101
Title: Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease.
Journal: Journal of inherited metabolic disease 20040101
Title: Simple and rapid determination of 1-deoxynojirimycin in mulberry leaves.
Journal: BioFactors (Oxford, England) 20040101
Title: [Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy].
Journal: MMW Fortschritte der Medizin 20031218
Title: Glycosidase-substrate interactions analysis by STD-NMR spectroscopy: study of alpha-L-fucosidase.
Journal: Journal of the American Chemical Society 20031217
Title: Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms.
Journal: Biochemistry 20031202
Title: Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases.
Journal: Journal of the American Chemical Society 20031126
Title: Detailed dissection of a new mechanism for glycoside cleavage: alpha-1,4-glucan lyase.
Journal: Biochemistry 20031111
Title: N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset.
Journal: Cancer letters 20031110
Title: Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.
Journal: Angewandte Chemie (International ed. in English) 20031006
Title: General access to iminosugar C-glycoside building blocks by means of cross-metathesis: a gateway to glycoconjugate mimetics.
Journal: Organic letters 20030904
Title: Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.
Journal: The Biochemical journal 20030901
Title: Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.
Journal: The Journal of biological chemistry 20030808
Title: Concise and highly stereocontrolled synthesis of 1-deoxygalactonojirimycin and its congeners using dioxanylpiperidene, a promising chiral building block.
Journal: Organic letters 20030710
Title: Advancing towards a male contraceptive: a novel approach from an unexpected direction.
Journal: Trends in pharmacological sciences 20030701
Title: Chemoenzymatic syntheses of (-)-1-deoxymannojirimycin (DMJ) and its naturally occurring 6-O-alpha-L-rhamnopyranosyl glycoside.
Journal: Organic & biomolecular chemistry 20030621
Title: Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography.
Journal: Journal of chromatography. A 20030620
Title: Epitope-dependent blocking of the angiotensin-converting enzyme dimerization by monoclonal antibodies to the N-terminal domain of ACE: possible link of ACE dimerization and shedding from the cell surface.
Journal: Biochemistry 20030617
Title: Substrate reduction therapy: clinical evaluation in type 1 Gaucher disease.
Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20030529
Title: Gaucher disease and the clinical experience with substrate reduction therapy.
Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20030529
Title: Chemical chaperones--a new concept in drug research.
Journal: Chembiochem : a European journal of chemical biology 20030404
Title: Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.
Journal: Brain : a journal of neurology 20030401
Title: N-linked oligosaccharide processing, but not association with calnexin/calreticulin is highly correlated with endoplasmic reticulum-associated degradation of antithrombin Glu313-deleted mutant.
Journal: Archives of biochemistry and biophysics 20030315
Title: [Therapy decision based on the glucose triad. Drug treatment of type 2 diabetes].
Journal: MMW Fortschritte der Medizin 20030227
Title: [Drug for Gaucher disease also works as sperm inhibitor. Is the 'pill' for the man on its way?].
Journal: MMW Fortschritte der Medizin 20030213
Title: Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation.
Journal: The Journal of endocrinology 20030201
Title: Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.
Journal: The Journal of general virology 20030201
Title: Glycolipid depletion in antimicrobial therapy.
Journal: Molecular microbiology 20030101
Title: gem-Diamine 1-N-iminosugars and related iminosugars, candidate of therapeutic agents for tumor metastasis.
Journal: Current topics in medicinal chemistry 20030101
Title: Is there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus?
Journal: Drugs 20030101
Title: New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.
Journal: Advances in experimental medicine and biology 20030101
Title: A novel method for the assay of alpha-glucosidase inhibitory activity using a multi-channel oxygen sensor.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021201
Title: Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain.
Journal: The Journal of biological chemistry 20021122
Title: Biochemistry and biotechnological applications of Gluconobacter strains.
Journal: Applied microbiology and biotechnology 20021101
Title: Therapeutic options for the management of type 2 diabetes mellitus.
Journal: The American journal of managed care 20021101
Title: A general strategy for the practical synthesis of nojirimycin C-glycosides and analogues. Extension to the first reported example of an iminosugar 1-phosphonate.
Journal: The Journal of organic chemistry 20021004
Title: Understanding protein structure-function relationships in Family 47 alpha-1,2-mannosidases through computational docking of ligands.
Journal: Proteins 20021001
Title: HbA(1c) and glycemic profile, basal- and post-treatment with Miglitol, in an area with a Mediterranean diet.
Journal: Diabetes care 20021001
Title: Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
Journal: Neuropathology and applied neurobiology 20021001
Title: The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics.
Journal: Diabetes, obesity & metabolism 20020901
Title: The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.
Journal: Antiviral research 20020901
Title: Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.
Journal: Antiviral chemistry & chemotherapy 20020901
Title: Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.
Journal: The Biochemical journal 20020815
Title: 1-Aza-sugars from D-glucose. Preparation of 1-deoxy-5-dehydroxymethyl-nojirimycin, its analogues and evaluation of glycosidase inhibitory activity.
Journal: Bioorganic & medicinal chemistry 20020701
Title: Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa.
Journal: Bioscience, biotechnology, and biochemistry 20020701
Title: Synthesis of 1-deoxy-L-gulonojirimycin (L-guloDNJ) and 1-deoxy-D-talonojirimycin (D-taloDNJ).
Journal: Carbohydrate research 20020612
Title: Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study.
Journal: Diabetes, nutrition & metabolism 20020601
Title: pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells.
Journal: Biochemical and biophysical research communications 20020510
Title: Interferon-gamma increases the expression of glycosylated CD95 in B-leukemic cells: an inducible model to study the role of glycosylation in CD95-signalling and trafficking.
Journal: Cytokine 20020421
Title: Some amino sugars structurally related to 6-deoxymannojirimycin precursors prepared from methyl 6-deoxy-2,3-O-isopropylidene-alpha-D-lyxo-hexofuranosid-5-ulose and methyl 2,3-O-isopropylidene-alpha-D-lyxo-pentodialdo-1,4-furanoside.
Journal: Carbohydrate research 20020417
Title: Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions.
Journal: Virology 20020330
Title: Structure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes.
Journal: The Journal of biological chemistry 20020215
Title: A simple access to the D-mannosidase inhibitor, 1-deoxymannojirimycin.
Journal: Carbohydrate research 20020205
Title: The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.
Journal: Molecular pharmacology 20020101
Title: Potential pharmacokinetics interference between alpha-glucosidase inhibitors and other oral antidiabetic agents.
Journal: Diabetes care 20020101
Title: Low-dose N-butyldeoxynojirimycin (OGT 918) for type I Gaucher disease.
Journal: Blood cells, molecules & diseases 20020101
Title: [Reducing postprandial glucose levels. Glucosidase antagonists].
Journal: Pharmazie in unserer Zeit 20020101
Title: [Fabry's disease (alpha-galactosidase-A deficiency): recent therapeutic innovations].
Journal: Journal de la Societe de biologie 20020101
Title: Inhibition of catalytic and glucan-binding activities of a streptococcal GTF forming insoluble glucans.
Journal: Caries research 20020101
Title: Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides.
Journal: The Journal of biological chemistry 20011130
Title: Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose.
Journal: Organic letters 20011018
Title: Miglitol combined with metformin improves glycaemic control in type 2 diabetes.
Journal: Diabetes, obesity & metabolism 20011001
Title: Critical role for glycosphingolipids in Niemann-Pick disease type C.
Journal: Current biology : CB 20010821
Title: Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits.
Journal: British journal of pharmacology 20010801
Title: Galactonojirimycin derivatives restore mutant human beta-galactosidase activities expressed in fibroblasts from enzyme-deficient knockout mouse.
Journal: Brain & development 20010801
Title: [The alpha-glucosidase inhibitor miglitol for the treatment of type 2 diabetes mellitus in the doctor's office].
Journal: Fortschritte der Medizin. Originalien 20010719
Title: Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor.
Journal: British journal of pharmacology 20010701
Title: Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits.
Journal: Japanese circulation journal 20010701
Title: A new era in type 2 diabetes mellitus treatment?
Journal: The American journal of medicine 20010701
Title: Therapeutic applications of sugar-mimicking glycosidase inhibitors.
Journal: Mini reviews in medicinal chemistry 20010701
Title: Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
Journal: The EMBO journal 20010615
Title: Synthesis and structure determination of some sugar amino acids related to alanine and 6-deoxymannojirimycin.
Journal: Carbohydrate research 20010615
Title: The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes.
Journal: Diabetes care 20010601
Title: Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.
Journal: Hepatology (Baltimore, Md.) 20010601
Title: Noeuromycin, a glycosyl cation mimic that strongly inhibits glycosidases.
Journal: Journal of the American Chemical Society 20010530
Title: Inhibition of N-linked glycosylation.
Journal: Current protocols in immunology 20010501
Title: [Alpha-glucosidase inhibitor in type 2 diabetic patients. Metabolism and body weight are favorably modified].
Journal: MMW Fortschritte der Medizin 20010426
Title: Crystal structure of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. 1011 complexed with 1-deoxynojirimycin at 2.0 A resolution.
Journal: Journal of biochemistry 20010401
Title: N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours.
Journal: British journal of cancer 20010401
Title: Retention of glucose on oligosaccharide chains linked to the LH/hCG receptor prevents cell surface expression.
Journal: Biochemical and biophysical research communications 20010330
Title: Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection.
Journal: The Journal of infectious diseases 20010301
Title: Role of complex asparagine-linked oligosaccharides in the expression of a functional thyrotropin receptor.
Journal: The Biochemical journal 20010301
Title: Substrate reduction therapy for glycosphingolipid storage disorders.
Journal: Expert opinion on investigational drugs 20010301
Title: Improved glycaemic control with miglitol in inadequately-controlled type 2 diabetics.
Journal: Diabetes research and clinical practice 20010301
Title: Slow inhibition of almond beta-glucosidase by azasugars: determination of activation energies for slow binding.
Journal: Biochimica et biophysica acta 20010209
Title: Synthesis of D- and L-deoxymannojirimycin via an asymmetric aminohydroxylation of vinylfuran.
Journal: Organic letters 20010208
Title: Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae).
Journal: European journal of biochemistry 20010101
Title: Enhanced survival in Sandhoff disease mice receiving a combination of substrate deprivation therapy and bone marrow transplantation.
Journal: Blood 20010101
Title: Role of CD44H carbohydrate structure in neuroblastoma adhesive properties.
Journal: Medical and pediatric oncology 20010101
Title: Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19991012
Title: Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells.
Journal: Journal of neurochemistry 19990301
Title: Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
Journal: Journal of medicinal chemistry 19980702
Title: Boromycin, an anti-HIV antibiotic.
Journal: Bioscience, biotechnology, and biochemistry 19960601
Title: Synthesis of alpha-glucosidase I inhibitors showing antiviral (HIV-1) and immunosuppressive activity.
Journal: The Journal of pharmacy and pharmacology 19960201
Title: The safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3.
Journal: Journal of acquired immune deficiency syndromes 19940201
Title: 6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs.
Journal: AIDS (London, England) 19910601
Title: Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity.
Journal: Virology 19910301
Title: Inhibitory effect of novel 1-deoxynojirimycin derivatives on HIV-1 replication.
Journal: AIDS (London, England) 19901001
Title: Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.
Journal: Japanese journal of medical science & biology 19900601
Title: Attenuation of HIV-1 infectivity by an inhibitor of oligosaccharide processing.
Journal: AIDS research and human retroviruses 19900601
Title: Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
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