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[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US9266841,2016,B2Locationinpatent:Page/Pagecolumn42
[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-EP2651403,2020,B1Locationinpatent:Paragraph0098;0099
[1]CurrentPatentAssignee:ROWANUNIVERSITY;THOMASJEFFERSONUNIVERSITY-EP2977452,2016,A2Locationinpatent:Paragraph0102
Title: Lipoprotein-associated Phospholipase A2 and Coronary Heart Disease.
Journal: Current pharmaceutical design 20180101
Title: The associations of stroke, transient ischemic attack, and/or stroke-related recurrent vascular events with Lipoprotein-associated phospholipase A2: A systematic review and meta-analysis.
Journal: Medicine 20171201
Title: Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA(2)).
Journal: Journal of medicinal chemistry 20161208
Title: Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study.
Journal: Ophthalmology 20150501
Title: Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial.
Journal: JAMA 20140910
Title: Darapladib for preventing ischemic events in stable coronary heart disease.
Journal: The New England journal of medicine 20140501
Title: Darapladib effect on circulating high sensitive troponin in patients with acute coronary syndromes.
Journal: Atherosclerosis 20121101
Title: Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.
Journal: Journal of lipid research 20120901
Title: Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis.
Journal: The international journal of cardiovascular imaging 20120401
Title: Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
Journal: Lancet (London, England) 20120331
Title: Utility of Lp-PLA2 in lipid-lowering therapy.
Journal: American journal of therapeutics 20120301
Title: Impact of analyzing fewer image frames per segment during offline volumetric radiofrequency-based intravascular ultrasound measurements of target lesions prior to percutaneous coronary interventions.
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Title: Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission.
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Title: Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status).
Journal: PloS one 20120101
Title: Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging.
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Title: Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
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Title: Therapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2).
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Title: The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice.
Journal: Acta pharmacologica Sinica 20111001
Title: Study design and rationale for the Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome.
Journal: American heart journal 20111001
Title: Lipoprotein-associated phospholipase A2: how effective as a risk marker of cardiovascular disease and as a therapeutic target?
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Title: Peripheral artery disease, biomarkers, and darapladib.
Journal: American heart journal 20110501
Title: The role of lipoprotein-associated phospholipase a₂ as a marker and potential therapeutic target in atherosclerosis.
Journal: Current atherosclerosis reports 20110401
Title: IVUS-based imaging modalities for tissue characterization: similarities and differences.
Journal: The international journal of cardiovascular imaging 20110201
Title: Ultrasound and light: friend or foe? On the role of intravascular ultrasound in the era of optical coherence tomography.
Journal: The international journal of cardiovascular imaging 20110201
Title: Assessment of coronary atherosclerosis by IVUS and IVUS-based imaging modalities: progression and regression studies, tissue composition and beyond.
Journal: The international journal of cardiovascular imaging 20110201
Title: [Novel therapy for atherosclerosis and inflammatory vascular disease].
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Title: Study design and rationale of 'Synergistic effect of combination therapy with cilostazol and ProbUcol on plaque stabilization and lesion REgression (SECURE)' study: a double-blind randomised controlled multicenter clinical trial.
Journal: Trials 20110101
Title: Focus on the research utility of intravascular ultrasound - comparison with other invasive modalities.
Journal: Cardiovascular ultrasound 20110101
Title: Animal models of cardiovascular diseases.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.
Journal: PloS one 20110101
Title: The vulnerable plaque: the real villain in acute coronary syndromes.
Journal: The open cardiovascular medicine journal 20110101
Title: Racial variation in lipoprotein-associated phospholipase A₂ in older adults.
Journal: BMC cardiovascular disorders 20110101
Title: Inhibition of lipoprotein-associated phospholipase A2 ameliorates inflammation and decreases atherosclerotic plaque formation in ApoE-deficient mice.
Journal: PloS one 20110101
Title: Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review.
Journal: Lipids in health and disease 20110101
Title: Phospholipase A2 inhibition and atherosclerotic vascular disease: prospects for targeting secretory and lipoprotein-associated phospholipase A2 enzymes.
Journal: Current opinion in lipidology 20101201
Title: Phospholipase A2s: developing drug targets for atherosclerosis.
Journal: Atherosclerosis 20101001
Title: Study design and rationale for the clinical outcomes of the STABILITY Trial (STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY) comparing darapladib versus placebo in patients with coronary heart disease.
Journal: American heart journal 20101001
Title: Darapladib: an emerging therapy for atherosclerosis.
Journal: Therapeutic advances in cardiovascular disease 20100801
Title: Editorial: why inhibition of lipoprotein-associated phospholipase A2 has the potential to improve patient outcomes.
Journal: Current opinion in cardiology 20100701
Title: Trial watch: a boost for GSK's first-in-class heart drug?
Journal: Nature reviews. Drug discovery 20100701
Title: Extracellular phospholipases in atherosclerosis.
Journal: Biochimie 20100601
Title: Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis.
Journal: The international journal of cardiovascular imaging 20100601
Title: Lipoprotein-associated phospholipase A2 activity and incident coronary heart disease among men and women with type 2 diabetes.
Journal: Diabetes 20100501
Title: Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies.
Journal: Lancet (London, England) 20100501
Title: A new method to measure necrotic core and calcium content in coronary plaques using intravascular ultrasound radiofrequency-based analysis.
Journal: The international journal of cardiovascular imaging 20100401
Title: Lipoprotein-associated phospholipase A2: role in atherosclerosis and utility as a cardiovascular biomarker.
Journal: Expert review of cardiovascular therapy 20100301
Title: Lipoprotein-associated phospholipase A2: a new therapeutic target.
Journal: The Canadian journal of cardiology 20100301
Title: Darapladib.
Journal: Expert opinion on investigational drugs 20100101
Title: Lp-PLA2: A new target for statin therapy.
Journal: Current atherosclerosis reports 20100101
Title: Association of carotid plaque Lp-PLA(2) with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke.
Journal: PloS one 20100101
Title: Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.
Journal: Cardiology research and practice 20100101
Title: Lipoprotein-associated phospholipase A(2) and atherosclerosis.
Journal: Current opinion in lipidology 20091001
Title: Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic.
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Title: Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease.
Journal: IDrugs : the investigational drugs journal 20091001
Title: Darapladib and atherosclerotic plaque: should lipoprotein-associated phospholipase A2 be a therapeutic target?
Journal: Current atherosclerosis reports 20090901
Title: Phospholipase A2 inhibitors.
Journal: Current opinion in lipidology 20090801
Title: Update on patented cholesterol absorption inhibitors.
Journal: Expert opinion on therapeutic patents 20090801
Title: Lipoprotein-associated phospholipase A2 as a biomarker of coronary heart disease and a therapeutic target.
Journal: Current opinion in cardiology 20090701
Title: Phospholipase A2 inhibitors in atherosclerosis: the race is on.
Journal: Lancet (London, England) 20090221
Title: Low and high density lipoprotein--cholesterol and coronary atherothrombosis.
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Title: Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development.
Journal: Nature medicine 20081001
Title: Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque.
Journal: Circulation 20080909
Title: Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?
Journal: Circulation 20080909
Title: The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-blind, placebo-controlled study.
Journal: Journal of the American College of Cardiology 20080429
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080401
Title: Gateways to clinical trials. July-August 2008.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060901
Title: The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
Journal: Bioorganic & medicinal chemistry letters 20030324
Title: Anti-inflammatory properties of a platelet-activating factor acetylhydrolase.
Journal: Nature 19950406
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