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35693-99-3,MFCD12138000
Catalog No.:AA00ILLA

35693-99-3 | 1,1'-Biphenyl, 2,2',5,5'-tetrachloro-

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10mg
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Technical Information
Catalog Number:
AA00ILLA
Chemical Name:
1,1'-Biphenyl, 2,2',5,5'-tetrachloro-
CAS Number:
35693-99-3
Molecular Formula:
C12H6Cl4
Molecular Weight:
291.9880
MDL Number:
MFCD12138000
SMILES:
Clc1ccc(cc1c1cc(Cl)ccc1Cl)Cl
Properties
Properties
 
MP:
83-85°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
209  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Rotatable Bond Count:
1  
XLogP3:
6.1  

Literature

Title: Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180701

Title: PCB28 and PCB52 induce hepatotoxicity by impairing the autophagic flux and stimulating cell apoptosis in vitro.

Journal: Toxicology letters 20180601

Title: Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme.

Journal: Archives of toxicology 20170701

Title: Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.

Journal: The Journal of toxicological sciences 20170101

Title: Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age.

Journal: Neurotoxicology 20160301

Title: Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals.

Journal: Endocrinology 20151201

Title: Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001

Title: Inhibitory effects on osteoblast differentiation in vitro by the polychlorinated biphenyl mixture Aroclor 1254 are mainly associated with the dioxin-like constituents.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150801

Title: Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children's Study (NCS).

Journal: Epigenetics 20150801

Title: Lactational exposure to low levels of the six indicator non-dioxin-like polychlorinated biphenyls induces DNA damage and repression of neuronal activity, in juvenile male mice.

Journal: Toxicology 20150203

Title: Dopamine-dependent behavior in adult rats after perinatal exposure to purity-controlled polychlorinated biphenyl congeners (PCB52 and PCB180).

Journal: Toxicology letters 20140103

Title: Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes.

Journal: Toxicology and applied pharmacology 20131001

Title: Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months.

Journal: Chemical research in toxicology 20130819

Title: Neurodevelopmental and behavioral toxicity via lactational exposure to the sum of six indicator non-dioxin-like-polychlorinated biphenyls (∑6 NDL-PCBs) in mice.

Journal: Toxicology 20120904

Title: Biological monitoring of indoor-exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building.

Journal: Toxicology letters 20120813

Title: Enhanced transport of 2,2',5,5'-polychlorinated biphenyl by natural organic matter (NOM) and surfactant-modified fullerene nanoparticles (nC60).

Journal: Environmental science & technology 20120515

Title: Temporal trends of persistent organic pollutants: a comparison of different time series models.

Journal: Environmental science & technology 20120403

Title: PCB 9 exposure induces endothelial cell death while increasing intracellular calcium and ROS levels.

Journal: Environmental toxicology 20120301

Title: The characteristics of supramammillary cells projecting to the hippocampus in stress response in the rat.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120201

Title: Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs.

Journal: Toxicology letters 20111010

Title: Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells.

Journal: Toxicology 20110905

Title: Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat).

Journal: Toxicology letters 20110704

Title: Auditory effects of developmental exposure to purity-controlled polychlorinated biphenyls (PCB52 and PCB180) in rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110701

Title: Biotransformation of 2,2',5,5'-tetrachlorobiphenyl (PCB 52) and 3,3',4,4'-tetrachlorobiphenyl (PCB 77) by liver microsomes from four species of sea turtles.

Journal: Chemical research in toxicology 20110516

Title: In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110501

Title: Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved.

Journal: Neurochemistry international 20110101

Title: Long-term effects of environmentally relevant doses of 2,2',4,4',5,5' hexachlorobiphenyl (PCB153) on neurobehavioural development, health and spontaneous behaviour in maternally exposed mice.

Journal: Behavioral and brain functions : BBF 20110101

Title: Resonance light scattering technique for determination of polychlorinated biphenyls with silver nanoparticles.

Journal: Luminescence : the journal of biological and chemical luminescence 20110101

Title: Postnatal exposure to PCB 153 and PCB 180, but not to PCB 52, produces changes in activity level and stimulus control in outbred male Wistar Kyoto rats.

Journal: Behavioral and brain functions : BBF 20110101

Title: An alternative physiological role for the EmhABC efflux pump in Pseudomonas fluorescens cLP6a.

Journal: BMC microbiology 20110101

Title: New hydroxylated metabolites of 4-monochlorobiphenyl in whole poplar plants.

Journal: Chemistry Central journal 20110101

Title: Rapid detection of polychlorinated biphenyls at trace levels in real environmental samples by surface-enhanced Raman scattering.

Journal: Sensors (Basel, Switzerland) 20110101

Title: Investigation on the inclusions of PCB52 with cyclodextrins by performing DFT calculations and molecular dynamics simulations.

Journal: The journal of physical chemistry. A 20101223

Title: The effect of olestra on the absorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; and perfluorooctanoic acid.

Journal: Environment international 20101101

Title: Polychlorinated biphenyls (PCB-153) and (PCB-77) absorption in human liver (HepG2) and kidney (HK2) cells in vitro: PCB levels and cell death.

Journal: Environment international 20101101

Title: Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101101

Title: Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. Mechanisms involved.

Journal: Neuroscience 20100602

Title: Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.

Journal: Chemical research in toxicology 20100419

Title: Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men.

Journal: Environmental monitoring and assessment 20100301

Title: Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells.

Journal: Chemico-biological interactions 20091210

Title: In vivo biotransformation of 3,3',4,4'-tetrachlorobiphenyl by whole plants-poplars and switchgrass.

Journal: Environmental science & technology 20091001

Title: Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans.

Journal: Archives of biochemistry and biophysics 20090801

Title: Protective role of estrogen receptor-alpha on lower chlorinated PCB congener-induced DNA damage and repair in human tumoral breast cells.

Journal: Toxicology letters 20090710

Title: [Metabolism of 2,2',5,5'-tetrachlorobiphenyl (CB52) by rabbit liver microsomes].

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20090501

Title: Isolation and characterisation of polychlorinated biphenyl (PCB) degrading fungi from a historically contaminated soil.

Journal: Microbial cell factories 20090101

Title: Experimental verification of a model describing solid phase microextraction (SPME) of freely dissolved organic pollutants in sediment porewater.

Journal: Chemosphere 20080801

Title: Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeidian wastewater treatment plant.

Journal: Chemosphere 20080701

Title: Serum concentrations of indicator PCB congeners in the Czech adult population.

Journal: Chemosphere 20080701

Title: Genotoxic effects of PCB 52 and PCB 77 on cultured human peripheral lymphocytes.

Journal: Mutation research 20080630

Title: Immune cell counts and risks of respiratory infections among infants exposed pre- and postnatally to organochlorine compounds: a prospective study.

Journal: Environmental health : a global access science source 20080101

Title: Differential inhibition of hepatic microsomal alkoxyresorufin O-dealkylation activities by tetrachlorobiphenyls.

Journal: Chemico-biological interactions 20070815

Title: Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans.

Journal: Journal of molecular biology 20070629

Title: Pathways and products of the degradation of PCBs by the sodium dispersion method.

Journal: Chemosphere 20070601

Title: Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls.

Journal: Environmental health perspectives 20070401

Title: Polyethylene devices: passive samplers for measuring dissolved hydrophobic organic compounds in aquatic environments.

Journal: Environmental science & technology 20070215

Title: Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBS) in pregnant women from eastern Slovakia.

Journal: Environmental health perspectives 20070101

Title: Intestinal bioavailability and biotransformation of 3,3',4,4'-tetrachlorobiphenyl (CB 77) in in situ preparations of channel catfish following dietary induction of CYP1A.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20060420

Title: Effects of PCB 52 and PCB 77 on cell viability, [Ca(2+)](i) levels and membrane fluidity in mouse thymocytes.

Journal: Toxicology 20060116

Title: Bioavailability of 2,3',4,4',5-pentachlorobiphenyl (PCB118) and 2,2',5,5'-tetrachlorobiphenyl (PCB52) from soils using a rat model and a physiologically based extraction test.

Journal: Toxicology 20060105

Title: Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1).

Journal: Chemical research in toxicology 20060101

Title: Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha.

Journal: Biochemical pharmacology 20051219

Title: Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation.

Journal: Reproduction (Cambridge, England) 20051201

Title: Occurrence of pesticides, polychlorinated biphenyls (PCBs), and heavy metals in sediments from the Dniester River, Moldova.

Journal: Archives of environmental contamination and toxicology 20051101

Title: Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury.

Journal: Environmental health perspectives 20050801

Title: Changes in antioxidant defense systems by 2,2',5,5'-tetrachlorobiphenyl exposure in neuronal SK-N-MC cells.

Journal: Toxicology letters 20050617

Title: CYP35: xenobiotically induced gene expression in the nematode Caenorhabditis elegans.

Journal: Archives of biochemistry and biophysics 20050601

Title: New passive samplers for chlorinated semivolatile organic pollutants in ambient air.

Journal: Chemosphere 20050201

Title: Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring.

Journal: Environmental health perspectives 20050201

Title: Effects of 2,2',5,5'-tetrachlorobiphenyl (PCB52) on migration of chicken primordial germ cells.

Journal: Reproduction, fertility, and development 20050101

Title: Effects of PCBs 52 and 77 on Th1/Th2 balance in mouse thymocyte cell cultures.

Journal: Immunopharmacology and immunotoxicology 20050101

Title: Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague-Dawley rats.

Journal: Toxicology 20041015

Title: Synthesis of chlorinated and non-chlorinated biphenyl-2,3- and 3,4-catechols and their [2H3]-isotopomers.

Journal: Organic & biomolecular chemistry 20040921

Title: Effects of particulate carbonaceous matter on the bioavailability of benzo[a]pyrene and 2,2',5,5'-tetrachlorobiphenyl to the clam, Macoma balthica.

Journal: Environmental science & technology 20040901

Title: Evidence for pi-pi electron donor-acceptor interactions between pi-donor aromatic compounds and pi-acceptor sites in soil organic matter through pH effects on sorption.

Journal: Environmental science & technology 20040815

Title: Protective effect of ginseng extract against apoptotic cell death induced by 2,2',5,5'-tetrachlorobiphenyl in neuronal SK-N-MC cells.

Journal: Life sciences 20040813

Title: An unrecognized source of PCB contamination in schools and other buildings.

Journal: Environmental health perspectives 20040701

Title: Regional differences in chemical fate model outcome.

Journal: Chemosphere 20040601

Title: Ortho-substituted but not coplanar PCBs rapidly kill cerebellar granule cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040501

Title: A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040201

Title: A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: II. simulation of chronic exposure scenarios.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040201

Title: Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome p450 enzymes.

Journal: Chemico-biological interactions 20031215

Title: Polychlorinated biphenyl (PCB) degradation and persistence of a gfp-marked Ralstonia eutropha H850 in PCB-contaminated soil.

Journal: Applied microbiology and biotechnology 20031201

Title: Ortho-substituted PCBs kill thymocytes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031201

Title: Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls.

Journal: Toxicology and applied pharmacology 20030215

Title: PCBs, mercury, and organochlorine concentrations in lake trout, walleye, and whitefish from selected tribal fisheries in the Upper Great Lakes region.

Journal: Environmental toxicology 20021201

Title: Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells.

Journal: Toxicology and applied pharmacology 20020601

Title: Novel integrative passive samplers for the long-term monitoring of semivolatile organic air pollutants.

Journal: Journal of environmental monitoring : JEM 20020601

Title: Multiple effects of 2,2',5,5'-tetrachlorobiphenyl on oxidative phosphorylation in rat liver mitochondria.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020201

Title: The targets of 2,2',5,5'-tetrachlorobiphenyl in the respiratory chain of rat liver mitochondria revealed by modular kinetic analysis.

Journal: Molecular biology reports 20020101

Title: Analysis of effects of 2,2',5,5'-tetrachlorobiphenyl on the flux control in oxidative phosphorylation system in rat liver mitochondria.

Journal: Molecular biology reports 20020101

Title: The influence of salting out on the sorption of neutral organic compounds in estuaries.

Journal: Water research 20011201

Title: A systematic gene expression screen of Caenorhabditis elegans cytochrome P450 genes reveals CYP35 as strongly xenobiotic inducible.

Journal: Archives of biochemistry and biophysics 20011115

Title: The effect of 2,5,2',5'-tetrachlorobiphenyl on growth and death of the cyanobacterium Anabaena flos-aquae.

Journal: Environmental toxicology and chemistry 20011001

Title: Induction of apoptotic cell death by a p53-independent pathway in neuronal SK-N-MC cells after treatment with 2,2',5,5'-tetrachlorobiphenyl.

Journal: Toxicology 20010828

Title: Dietary uptake kinetics of 2,2',5,5'-tetrachlorobiphenyl in rainbow trout.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010701

Title: No enhancement in bioconcentration of organic contaminants by low levels of DOM.

Journal: Chemosphere 20010701

Title: Effects of 2,2',5,5'-tetrachlorobiphenyl and biphenyl on cell membranes of Ralstonia eutropha H850.

Journal: FEMS microbiology letters 20010612

Title: Induction of aberrant mitosis with PCBs: particular efficiency of 2, 3,3',4,4'-pentachlorobiphenyl and synergism with triphenyltin.

Journal: Mutagenesis 20000101

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SDS
Tags:35693-99-3 Molecular Formula|35693-99-3 MDL|35693-99-3 SMILES|35693-99-3 1,1'-Biphenyl, 2,2',5,5'-tetrachloro-