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35730-78-0,MFCD09752784
Catalog No.:AA00CHI0

35730-78-0 | cynaropicrin

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1mg
≥98%
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$116.00   $81.00
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5mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CHI0
Chemical Name:
cynaropicrin
CAS Number:
35730-78-0
Molecular Formula:
C19H22O6
Molecular Weight:
346.3744
MDL Number:
MFCD09752784
SMILES:
OCC(=C)C(=O)O[C@H]1CC(=C)[C@H]2[C@@H]([C@@H]3[C@@H]1C(=C)C(=O)O3)C(=C)[C@H](C2)O
Properties
Computed Properties
 
Complexity:
690  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
0.6  

Literature

Title: Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway.

Journal: Toxicology letters 20150416

Title: Genetic mapping and characterization of the globe artichoke (+)-germacrene A synthase gene, encoding the first dedicated enzyme for biosynthesis of the bitter sesquiterpene lactone cynaropicrin.

Journal: Plant science : an international journal of experimental plant biology 20120701

Title: Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei.

Journal: Planta medica 20120401

Title: Quantification of cynaropicrin in artichoke leaf extracts by ¹H NMR spectroscopy.

Journal: Planta medica 20111001

Title: Supercritical fluid extraction of cynaropicrin and 20-hydroxyecdysone from Leuzea carthamoides DC.

Journal: Journal of separation science 20080501

Title: Guaiane sesquiterpene lactones and amino acid-sesquiterpene lactone conjugates from the aerial parts of Saussurea pulchella.

Journal: Journal of natural products 20080401

Title: The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme.

Journal: Biological & pharmaceutical bulletin 20071201

Title: Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.

Journal: Bioorganic & medicinal chemistry letters 20061101

Title: Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum.

Journal: Biological & pharmaceutical bulletin 20050501

Title: Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines.

Journal: European journal of pharmacology 20040525

Title: Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions.

Journal: Biochemical and biophysical research communications 20040123

Title: Cho JY, et al. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol. 2000 Jun 23;398(3):399-407.

Title: Masutani T, et al. Cynaropicrin is dual regulator for both degradation factors and synthesis factors in the cartilage metabolism. Life Sci. 2016 Aug 1;158:70-7.

Title: da Silva CF, et al. Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo. Antimicrob Agents Chemother. 2013 Nov;57(11):5307-14.

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