[1]Porcari,AnthonyR.;Ptak,RogerG.;Borysko,KatherineZ.;Breitenbach,JulieM.;Vittori,Sauro;Wotring,LindaL.;Drach,JohnC.;Townsend,LeroyB.[JournalofMedicinalChemistry,2000,vol.43,#12,p.2438-2448]
[1]Hu,Chen;Ruan,Zhizhong;Ding,Haixin;Zhou,Yirong;Xiao,Qiang[Molecules,2017,vol.22,#4]
Title: Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180301
Title: Why are most phospholipidosis inducers also hERG blockers?
Journal: Archives of toxicology 20171201
Title: Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway.
Journal: Toxicology letters 20150805
Title: Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression.
Journal: International journal of molecular medicine 20131001
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Inhibitory roles of prohibitin and chemerin in FSH-induced rat granulosa cell steroidogenesis.
Journal: Endocrinology 20130201
Title: Akt or phosphoinositide-3-kinase inhibition reverses cardio-protection in Toll-like receptor 2 deficient mice.
Journal: Resuscitation 20121101
Title: Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling.
Journal: Journal of molecular and cellular cardiology 20121001
Title: Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer.
Journal: Cancer research 20120901
Title: The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression.
Journal: Cancer discovery 20120701
Title: Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia.
Journal: Translational research : the journal of laboratory and clinical medicine 20120601
Title: AKT inhibition by triciribine alone or as combination therapy for growth control of gastroenteropancreatic neuroendocrine tumors.
Journal: International journal of oncology 20120301
Title: Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells.
Journal: Toxicology 20120226
Title: FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer.
Journal: PloS one 20120101
Title: IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
Journal: The Journal of biological chemistry 20111028
Title: AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors.
Journal: Biological psychiatry 20110915
Title: Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation.
Journal: Stem cells and development 20110701
Title: JAM-A regulates epithelial proliferation through Akt/β-catenin signalling.
Journal: EMBO reports 20110401
Title: Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia.
Journal: Journal of cellular physiology 20110301
Title: Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation.
Journal: Endocrinology 20110201
Title: 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.
Journal: The Prostate 20101101
Title: Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.
Journal: Antimicrobial agents and chemotherapy 20100401
Title: Sensitivity of cardiac carnitine palmitoyltransferase to malonyl-CoA is regulated by leptin: similarities with a model of endogenous hyperleptinemia.
Journal: Endocrinology 20100301
Title: Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle.
Journal: Molecular and cellular endocrinology 20100205
Title: Chronic hyperleptinemia induces resistance to acute natriuretic and NO-mimetic effects of leptin.
Journal: Peptides 20100101
Title: A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB.
Journal: PloS one 20100101
Title: 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway.
Journal: Chemical research in toxicology 20091201
Title: Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy.
Journal: European journal of obstetrics, gynecology, and reproductive biology 20090901
Title: The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.
Journal: International journal of cancer 20090815
Title: Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Journal: Gene therapy 20090401
Title: [Akt enzyme: new therapeutic target in cancer and diabetes?].
Journal: Orvosi hetilap 20090222
Title: High-throughput screening compatible cell-based assay for interrogating activated notch signaling.
Journal: Assay and drug development technologies 20090201
Title: Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization.
Journal: The Biochemical journal 20090101
Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal: Journal of medicinal chemistry 20081113
Title: Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells.
Journal: Journal of cellular physiology 20081101
Title: The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.
Journal: Bioorganic & medicinal chemistry 20080901
Title: Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB.
Journal: Neuropeptides 20080601
Title: MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN.
Journal: Cancer research 20080115
Title: Resistin, an adipocytokine, offers protection against acute myocardial infarction.
Journal: Journal of molecular and cellular cardiology 20071101
Title: Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071001
Title: Correlation of PIK3Ca mutations with gene expression and drug sensitivity in NCI-60 cell lines.
Journal: Biochemical and biophysical research communications 20060210
Title: Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer.
Journal: Current opinion in investigational drugs (London, England : 2000) 20051201
Title: Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine.
Journal: Journal of medicinal chemistry 20050602
Title: Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents.
Journal: Bioorganic & medicinal chemistry letters 20040705
Title: An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties.
Journal: Nucleosides, nucleotides & nucleic acids 20040101
Title: Synthesis and antiviral activity of 2-substituted analogs of triciribine.
Journal: Nucleosides, nucleotides & nucleic acids 20031201
Title: Synthesis of carbocyclic analogs of 2',3'-dideoxysangivamycin, 2',3'-dideoxytoyocamycin, and 2',3'-dideoxytriciribine.
Journal: Nucleosides, nucleotides & nucleic acids 20010101
Title: Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation.
Journal: Journal of medicinal chemistry 20000615
Title: Phosphorylation of triciribine is necessary for activity against HIV type 1.
Journal: AIDS research and human retroviruses 19981010
Title: Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2.
Journal: AIDS research and human retroviruses 19930401
Title: Dual mechanisms of inhibition of DNA synthesis by triciribine.
Journal: Cancer research 19900815
Title: Dieterle A, et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125(4):932-41.
Title: Gürsel DB, et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma. Neuro Oncol. 2011 Jun;13(6):610-21
Title: Kucera LS, et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14.
Title: Abdalla M, et al. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172(16):4173-88.
