Title: Why are most phospholipidosis inducers also hERG blockers?
Journal: Archives of toxicology 20171201
Title: Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120929
Title: Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.
Journal: Journal of pharmaceutical sciences 20120901
Title: Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
Journal: Chirality 20120701
Title: Influence of bile on the absorption of halofantrine from lipid-based formulations.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120601
Title: In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS).
Journal: Journal of controlled release : official journal of the Controlled Release Society 20120530
Title: Distribution of drug resistance genotypes in Plasmodium falciparum in an area of limited parasite diversity in Saudi Arabia.
Journal: The American journal of tropical medicine and hygiene 20120501
Title: Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease.
Journal: BMC systems biology 20120101
Title: CDA: combinatorial drug discovery using transcriptional response modules.
Journal: PloS one 20120101
Title: Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.
Journal: Molecular pharmaceutics 20110801
Title: Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats.
Journal: The Journal of pharmacy and pharmacology 20110601
Title: Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.
Journal: PLoS genetics 20110401
Title: In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug: halofantrine.
Journal: Asian Pacific journal of tropical medicine 20110401
Title: A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110318
Title: Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection.
Journal: Journal of pharmaceutical and biomedical analysis 20110105
Title: Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?
Journal: Molecular pharmaceutics 20101206
Title: Effect of experimental hyperlipidaemia on the electrocardiographic effects of repeated doses of halofantrine in rats.
Journal: British journal of pharmacology 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Is halofantrine ototoxic? Experimental study on guinea pig cochlea model.
Journal: The Journal of laryngology and otology 20101001
Title: In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
Journal: African health sciences 20100601
Title: Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs.
Journal: Chirality 20100201
Title: Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats.
Journal: The Journal of pharmacy and pharmacology 20100101
Title: Structural analysis of the antimalarial drug halofantrine by means of Raman spectroscopy and density functional theory calculations.
Journal: Journal of biomedical optics 20100101
Title: Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system.
Journal: Malaria journal 20100101
Title: Chemotherapeutic interaction between Khaya grandifoliola (WELW) CDC stem bark extract and two anti-malarial drugs in mice.
Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20100101
Title: Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers.
Journal: Journal of clinical pharmacy and therapeutics 20091201
Title: Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU.
Journal: The Journal of pharmacology and experimental therapeutics 20091101
Title: Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415
Title: Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base.
Journal: Malaria journal 20090101
Title: Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20081002
Title: The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials.
Journal: Journal of inorganic biochemistry 20080801
Title: Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats.
Journal: Basic & clinical pharmacology & toxicology 20080401
Title: Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine.
Journal: European journal of clinical pharmacology 20080101
Title: Dissolution properties and characterization of halofantrine-2-hydroxypropyl-beta-cyclodextrin binary systems.
Journal: Die Pharmazie 20071101
Title: Effect of polymer molecular weight on the production of drug nanoparticles.
Journal: Journal of pharmaceutical sciences 20071001
Title: Lariam and Halfan.
Journal: Journal of the Royal Society of Medicine 20070801
Title: The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.
Journal: Annals of tropical medicine and parasitology 20070701
Title: A lesson learnt: the rise and fall of Lariam and Halfan.
Journal: Journal of the Royal Society of Medicine 20070401
Title: Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.
Journal: Therapeutic drug monitoring 20070401
Title: Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices.
Journal: Life sciences 20070313
Title: The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism.
Journal: Chirality 20070101
Title: Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach.
Journal: Malaria journal 20070101
Title: Intravascular haemolysis following treatment of malaria with halofantrine: case report.
Journal: Nigerian journal of clinical practice 20061201
Title: Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
Journal: The Journal of infectious diseases 20060815
Title: Efficacy and safety of halofantrine in Pakistani children and adults with malaria caused by P. falciparum and P. vivax.
Journal: The Southeast Asian journal of tropical medicine and public health 20060701
Title: An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20060411
Title: Comparative determination of halofantrine tablets by titrimetry, spectrophotometry and liquid chromatography.
Journal: African journal of medicine and medical sciences 20060301
Title: The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.
Journal: The Journal of pharmacology and experimental therapeutics 20060201
Title: Surface-modified and conventional nanocapsules as novel formulations for parenteral delivery of halofantrine.
Journal: Journal of nanoscience and nanotechnology 20060101
Title: Bile increases intestinal lymphatic drug transport in the fasted rat.
Journal: Pharmaceutical research 20051101
Title: pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.
Journal: Molecular microbiology 20050801
Title: Enzymatic characterization of lipid-based drug delivery systems.
Journal: International journal of pharmaceutics 20050725
Title: Antimalarial drugs: QT prolongation and cardiac arrhythmias.
Journal: Expert opinion on drug safety 20050501
Title: [Mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20050401
Title: Antimalarial prescribing practices: a challenge to malaria control in Ghana.
Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101
Title: Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041201
Title: Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.
Journal: Molecular cell 20040924
Title: Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats.
Journal: Pharmaceutical research 20040801
Title: Effects of tetracycline on the pharmacokinetics of halofantrine in healthy volunteers.
Journal: British journal of clinical pharmacology 20040701
Title: The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
Journal: Antimicrobial agents and chemotherapy 20040701
Title: Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum.
Journal: Biochemistry 20040504
Title: Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine.
Journal: Journal of pharmaceutical sciences 20040501
Title: Emerging drug--resistance and guidelines for treatment of malaria.
Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20040501
Title: Influence of physicochemical properties on the patterns of association of a series of aliphatic esters of halofantrine with plasma lipoproteins.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20040305
Title: Genetic and biochemical aspects of drug resistance in malaria parasites.
Journal: Current drug targets. Infectious disorders 20040301
Title: Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations.
Journal: Pharmaceutical research 20040201
Title: Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids.
Journal: Pharmaceutical research 20040201
Title: Halofantrine efficacy in non-immune children with imported acute Plasmodium falciparum malaria Infection.
Journal: European journal of pediatrics 20040101
Title: Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetized rabbit model.
Journal: The Journal of pharmacy and pharmacology 20040101
Title: [Treatment of uncomplicated Plasmodium falciparum malaria in children: comparison of halofantrine with mefloquine].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20031201
Title: Determination of physicochemical properties of halofantrine.
Journal: African journal of medicine and medical sciences 20031201
Title: Partitioning of halofantrine hydrochloride between water, micellar solutions, and soybean oil: Effects on its apparent ionization constant.
Journal: Journal of pharmaceutical sciences 20031101
Title: Short report: in vivo sensitivity of Plasmodium falciparum to halofantrine in southern central Vietnam.
Journal: The American journal of tropical medicine and hygiene 20031101
Title: Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030901
Title: Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs.
Journal: Pharmaceutical research 20030901
Title: Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?
Journal: Biopharmaceutics & drug disposition 20030501
Title: [Long circulating nanocapsules: interest in the treatment of severe malaria with halofantrine].
Journal: Annales pharmaceutiques francaises 20030501
Title: Effects of halofantrine hydrochloride (halfan) on the histology of the ovary of mature female Wistar rats.
Journal: African journal of reproductive health 20030401
Title: The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults.
Journal: American journal of respiratory and critical care medicine 20030301
Title: Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers.
Journal: Chemical & pharmaceutical bulletin 20030301
Title: [Antiprotozoal drugs].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201
Title: [Adverse drug reactions (ADRs) to antimalarial drugs. Analysis of spontaneous report from the French pharmacovigilance database (1996-2000)].
Journal: Presse medicale (Paris, France : 1983) 20030125
Title: In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum.
Journal: Tropical medicine & international health : TM & IH 20030101
Title: Identification of the 'wrong' active pharmaceutical ingredient in a counterfeit Halfan drug product using accurate mass electrospray ionisation mass spectrometry, accurate mass tandem mass spectrometry and liquid chromatography/mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20030101
Title: [Drug resistant tropical malaria in the Republic of Guinea (West Africa)].
Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20030101
Title: Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine.
Journal: Clinical pharmacology and therapeutics 20021101
Title: [Blackwater fever].
Journal: Presse medicale (Paris, France : 1983) 20020907
Title: The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.
Journal: Cardiovascular research 20020901
Title: Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats.
Journal: Pharmaceutical research 20020901
Title: The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins.
Journal: Journal of pharmaceutical sciences 20020801
Title: Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation.
Journal: The Journal of pharmacy and pharmacology 20020801
Title: A new high-performance liquid chromatography (HPLC) method for the analysis of halofantrine (HF) in pharmaceuticals.
Journal: Journal of pharmaceutical and biomedical analysis 20020731
Title: The effects of antimalarial drugs on ventricular repolarization.
Journal: The American journal of tropical medicine and hygiene 20020701
Title: [A collective malarial infestation during a humanitarian mission in west Africa].
Journal: Bulletin de la Societe de pathologie exotique (1990) 20020601
Title: In-vitro sensitivity of Plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in Madagascar.
Journal: East African medical journal 20020501
Title: [Imported malaria in children in 1999. Study of the Armand-Trousseau Hospital in Paris].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020401
Title: Preparation and in vitro evaluation of solid dispersions of halofantrine.
Journal: International journal of pharmaceutics 20020320
Title: A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs.
Journal: Journal of pharmaceutical sciences 20020301
Title: Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants.
Journal: The American journal of tropical medicine and hygiene 20020301
Title: Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes.
Journal: British journal of pharmacology 20020201
Title: Proliposomes for oral drug administration.
Journal: Cellular & molecular biology letters 20020101
Title: [Efficacy of mefloquine, halofantrine, and coarteme in the treatment of tropical malaria].
Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20020101
Title: Severe cardiac toxicity due to halofantrine: importance of underlying heart disease.
Journal: Journal of travel medicine 20020101
Title: Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20011201
Title: A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine.
Journal: Journal of pharmaceutical sciences 20011001
Title: Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids.
Journal: Pharmaceutical research 20010901
Title: [Cardiac rhythm disturbances and prolonged QT interval with halofantrine].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20010801
Title: Sudden death in a traveller following halofantrine administration--Togo, 2000.
Journal: Canada communicable disease report = Releve des maladies transmissibles au Canada 20010715
Title: Halofantrine-phospholipid interactions: monolayer studies.
Journal: Chemical & pharmaceutical bulletin 20010701
Title: Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports.
Journal: Annals of tropical medicine and parasitology 20010701
Title: Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases.
Journal: The Southeast Asian journal of tropical medicine and public health 20010601
Title: Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants.
Journal: Bioscience reports 20010601
Title: [Halofantrine in pediatrics: survey in Ile-de-France].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20010501
Title: From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000.
Journal: JAMA 20010411
Title: Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A.
Journal: The American journal of cardiology 20010401
Title: Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation.
Journal: British journal of clinical pharmacology 20010301
Title: Effects of anti-protozoal drugs and histopathological studies on trypanosome species.
Journal: FEMS immunology and medical microbiology 20010201
Title: Potentiation of halofantrine-induced QTc prolongation by mefloquine: correlation with blood concentrations of halofantrine.
Journal: British journal of pharmacology 20010101
Title: A high-performance liquid chromatographic assay for the determination of desbutylhalofantrine enantiomers in rat plasma.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20010101
Title: Mechanism of cardiotoxicity of halofantrine.
Journal: Clinical pharmacology and therapeutics 20000501
Title: Cardiac effects of standard-dose halofantrine therapy.
Journal: The American journal of tropical medicine and hygiene 19960301
Title: Cardiac complications of halofantrine: a prospective study of 20 patients.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 19950101
Title: Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand.
Journal: The American journal of tropical medicine and hygiene 19940201
Title: [Cardiac complications of halofantrine: continuous electrocardiographic study (holter) in 20 patients].
Journal: La Revue de medecine interne 19930101
Title: [Ventricular arrhythmia and halofantrine intake. Probable deleterious effect. Apropos of 3 cases].
Journal: Bulletin de la Societe de pathologie exotique (1990) 19930101
Title: Krishna S, et al. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993 Dec;36(6):585-91.
Title: Tie, H., et al., Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br. J. Pharmacol. 130, 1967-1975, (2000) Traebert.
