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36330-85-5,MFCD00056701
Catalog No.:AA003K3G

36330-85-5 | Fenbufen

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100mg
99%
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$6.00   $4.00
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5g
98%(HPLC)
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$24.00   $17.00
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25g
98%(HPLC)
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100g
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500g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003K3G
Chemical Name:
Fenbufen
CAS Number:
36330-85-5
Molecular Formula:
C16H14O3
Molecular Weight:
254.2806
MDL Number:
MFCD00056701
SMILES:
O=C(c1ccc(cc1)c1ccccc1)CCC(=O)O
NSC Number:
757812
Properties
Properties
 
BP:
470.2°C at 760 mmHg  
Form:
Solid  
MP:
184-187 °C(lit.);  
Refractive Index:
1.5600 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
310  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Literature

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Journal: European journal of pharmacology 20120615

Title: Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

Journal: The Cochrane database of systematic reviews 20120215

Title: Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study.

Journal: International journal of nanomedicine 20120101

Title: Effect of rare Earth ions on the properties of composites composed of ethylene vinyl acetate copolymer and layered double hydroxides.

Journal: PloS one 20120101

Title: 5-(Biphenyl-4-yl)-3-(3-meth-oxy-benzyl-idene)furan-2(3H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110901

Title: Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system.

Journal: Colloids and surfaces. B, Biointerfaces 20110501

Title: Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Modelling, solubility and pK(a) of five sparingly soluble drugs.

Journal: International journal of pharmaceutics 20110117

Title: Screening of conditions controlling spectrophotometric sequential injection analysis.

Journal: Chemistry Central journal 20110101

Title: Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro.

Journal: BMC pharmacology 20110101

Title: PubChem3D: Similar conformers.

Journal: Journal of cheminformatics 20110101

Title: Single dose oral analgesics for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews 20110101

Title: Biomedical exploitation of chitin and chitosan via mechano-chemical disassembly, electrospinning, dissolution in imidazolium ionic liquids, and supercritical drying.

Journal: Marine drugs 20110101

Title: Synthesis and structure-activity relationships of fenbufen amide analogs.

Journal: Molecules (Basel, Switzerland) 20101202

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Influence of relative humidity on the interaction between different aryl propionic acid derivatives and poly(vinylpyrrolydone) K30: evaluation of the effect on drug bioavailability.

Journal: International journal of pharmaceutics 20101015

Title: Inclusion and release of fenbufen in mesoporous silica.

Journal: Journal of pharmaceutical sciences 20100801

Title: Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori.

Journal: Dalton transactions (Cambridge, England : 2003) 20100321

Title: Risk of Upper Gastrointestinal Bleeding in a Cohort of New Users of Low-Dose ASA for Secondary Prevention of Cardiovascular Outcomes.

Journal: Frontiers in pharmacology 20100101

Title: Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach.

Journal: Journal of pharmaceutical sciences 20091101

Title: Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.

Journal: European journal of medicinal chemistry 20090901

Title: Combining a solution-phase derived library with in-situ cellular bioassay: prompt screening of amide-forming minilibraries using MTT assay.

Journal: Chemical & pharmaceutical bulletin 20090701

Title: In vitro genotoxic assessment of xenobiotic diacylglycerols in an in vitro micronucleus assay.

Journal: Environmental and molecular mutagenesis 20090501

Title: Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain.

Journal: Fundamental & clinical pharmacology 20090401

Title: Photoreactivity of biologically active compounds. XIX: excited states and free radicals from the antimalarial drug primaquine.

Journal: Journal of photochemistry and photobiology. B, Biology 20090303

Title: Effects of nonsteroidal anti-inflammatory drugs on the expression and function of P-glycoprotein/MDR1 in Caco-2 cells.

Journal: Drug and chemical toxicology 20090101

Title: Single dose oral fenbufen for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews 20090101

Title: A seizure attributed to ofloxacine in a woman undergoing detoxification for alcohol dependence.

Journal: Case reports in medicine 20090101

Title: Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

Journal: Journal of medicinal chemistry 20081225

Title: Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples.

Journal: Journal of chromatography. A 20080815

Title: Combination of solid-phase extraction and large-volume stacking with polarity switching in micellar electrokinetic capillary chromatography for the determination of traces of nonsteroidal anti-inflammatory drugs in saliva.

Journal: Electrophoresis 20080701

Title: Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: sublimation, solution and solvation of biphenyl substituted drugs.

Journal: International journal of pharmaceutics 20080605

Title: Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.

Journal: Current neuropharmacology 20071201

Title: 6-aryl-4-oxohexanoic acids: synthesis, effects on eicosanoid biosynthesis, and anti-inflammatory in vivo-activities.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20070901

Title: Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction?

Journal: PLoS medicine 20070501

Title: Contribution of solid-state properties to the aqueous solubility of drugs.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101

Title: Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats.

Journal: European journal of pharmacology 20060814

Title: Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs.

Journal: Biological & pharmaceutical bulletin 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Determination of dissociation constants of cyclodextrin-ligand inclusion complexes by electrospray ionization mass spectrometry.

Journal: European journal of mass spectrometry (Chichester, England) 20060101

Title: 1H-NMR study of the inclusion processes for alpha- and gamma-cyclodextrin with fenbufen.

Journal: Biopolymers 20050415

Title: In-tube solid phase microextraction using a beta-cyclodextrin coated capillary coupled to high performance liquid chromatography for determination of non-steroidal anti-inflammatory drugs in urine samples.

Journal: Talanta 20050115

Title: Celecoxib does not induce convulsions nor does it affect GABAA receptor binding activity in the presence of new quinolones in mice.

Journal: European journal of pharmacology 20050110

Title: Applications of derivative UV spectrophotometry for the determinations of fenbufen and ketoprofen in pharmaceutical preparations.

Journal: Acta poloniae pharmaceutica 20050101

Title: Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population.

Journal: BMC medicine 20050101

Title: Enteric-coated layered double hydroxides as a controlled release drug delivery system.

Journal: International journal of pharmaceutics 20041209

Title: Practical synthesis of fenbufen ethanolamide.

Journal: Archiv der Pharmazie 20041001

Title: Risk of breast cancer among users of aspirin and other anti-inflammatory drugs.

Journal: British journal of cancer 20040802

Title: Inclusion complex of fenbufen with beta-cyclodextrin.

Journal: Biopolymers 20040301

Title: In vitro reactivity of carboxylic acid-CoA thioesters with glutathione.

Journal: Chemical research in toxicology 20040101

Title: [Surveillance on concurrent administration of quinolones and anti-inflammatory drugs in a community hospital].

Journal: The Japanese journal of antibiotics 20030801

Title: Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study.

Journal: British journal of cancer 20030602

Title: Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system.

Journal: The Journal of toxicological sciences 20030201

Title: The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes.

Journal: BMC pharmacology 20030101

Title: Syntheses and reactions of some new 2-arylidene-4-(biphenyl-4-yl)-but-3-en-4-olides with a study of their biological activity.

Journal: Die Pharmazie 20020701

Title: Evaluation of the malignant potential of aberrant crypt foci by immunohistochemical staining for beta-catenin in inflammation-induced rat colon carcinogenesis.

Journal: International journal of molecular medicine 20020401

Title: [Colitis enhances the colorectal carcinogenesis in rats: correlation between the incidence of aberrant crypt foci and the incidence of tumors].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20010501

Title: Determination of nonsteroidal anti-inflammatory drugs in biological fluids by automatic on-line integration of solid-phase extraction and capillary electrophoresis.

Journal: Electrophoresis 20010201

Title: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.

Journal: BMC clinical pharmacology 20010101

Title: Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.

Journal: Journal of analytical toxicology 20010101

Title: Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.

Journal: Japanese journal of pharmacology 19980401

Title: Circadian variation in enoxacin-induced convulsions in mice coadministered with fenbufen.

Journal: Japanese journal of pharmacology 19970201

Title: [Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19921001

Title: Interaction of the new quinolone antibacterial agent levofloxacin with fenbufen in mice.

Journal: Arzneimittel-Forschung 19920301

Title: Assessment of temafloxacin neurotoxicity in rodents.

Journal: The American journal of medicine 19911230

Title: Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs.

Journal: International journal of clinical pharmacology, therapy, and toxicology 19910601

Title: Aplastic anaemia associated with a non-steroidal anti-inflammatory drug: relapse after exposure to another such drug.

Journal: BMJ (Clinical research ed.) 19900707

Title: Fenbufen: a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain.

Journal: Drugs 19810101

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Title: R G Child, et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs, J Pharm Sci. 1977 Apr;66(4):466-76.

Title: A E Sloboda, et al. The pharmacology of fenbufen, 3-(4-biphenylylcarbonyl)propionic acid, and 4-biphenylacetic acid, interesting antiinflammatory-analgesic agents. Inflammation. 1976 Dec;1(4):415-38.

Title: Asif Husain, et al. Fenbufen based 3--(substituted aryl)-1,3,4-oxadiazol-2-yl-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem . 2009 Sep;44(9):3798-804.

Title: Christina E Smith, et al. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16;24(3):281-292.

Title: R M Palmer, et al. Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats. Br J Pharmacol. 1990 Dec;101(4):835-8.

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Tags:36330-85-5 Molecular Formula|36330-85-5 MDL|36330-85-5 SMILES|36330-85-5 Fenbufen