Home Fluorides 367-11-3
367-11-3,MFCD00000284
Catalog No.:AA00I76S

367-11-3 | 1,2-Difluorobenzene

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  • Technical Information
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Technical Information
Catalog Number:
AA00I76S
Chemical Name:
1,2-Difluorobenzene
CAS Number:
367-11-3
Molecular Formula:
C6H4F2
Molecular Weight:
114.0928
MDL Number:
MFCD00000284
SMILES:
C1=CC=C(C(=C1)F)F
NSC Number:
10275
Properties
Computed Properties
 
Complexity:
62.9  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
2.4  

Literature

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Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120716

Title: (Z)-3-(4-Chloro-phen-yl)-1-(2,4-difluoro-phen-yl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20120601

Title: 4-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1).

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: Sodium channels as targets for volatile anesthetics.

Journal: Frontiers in pharmacology 20120101

Title: Excited state ab initio and Franck-Condon simulation of S1 → S0 fluorescence excitation spectra of p-, m-, and o-difluorobenzenes.

Journal: The journal of physical chemistry. A 20111208

Title: Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.

Journal: Bioorganic & medicinal chemistry 20111201

Title: 4-(3-Chloro-phen-yl)-3-[(2,6-difluoro-benz-yl)sulfan-yl]-5-(3,4,5-trimeth-oxy-phen-yl)-4H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

Journal: ChemMedChem 20111004

Title: Hepatic safety of antibiotics used in primary care.

Journal: The Journal of antimicrobial chemotherapy 20110701

Title: (Z)-Ethyl 2-(4-chloro-phen-yl)-3-[(2,4-difluoro-phen-yl)amino]-prop-2-enoate.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: Push-pull electron effects of the complexant in a Li atom doped molecule with electride character: a new strategy to enhance the first hyperpolarizability.

Journal: Physical chemistry chemical physics : PCCP 20100921

Title: Synthesis, characterization, and crystal structures of silylium compounds of the weakly coordinating dianion [B(12)Cl(12)](2-).

Journal: Inorganic chemistry 20100607

Title: Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

Journal: PLoS neglected tropical diseases 20100401

Title: Flat-panel electronic displays: a triumph of physics, chemistry and engineering.

Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20100313

Title: Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity.

Journal: Anesthesia and analgesia 20100201

Title: (3-Allyl-oxypicolinato-κN,O)bis-[3,5-difluoro-2-(2-pyrid-yl)phenyl-κC,N]iridium(III).

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Ethyl 4-(2,4-difluoro-phen-yl)-6-methyl-2-oxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Ethyl 4-(2,4-difluoro-phen-yl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20090501

Title: Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

Journal: PloS one 20090101

Title: Synthesis and conformational studies of peptides from new C-linked carbo-beta-amino acids (beta-Caas) with anomeric methylamino- and difluorophenyl moieties.

Journal: Organic & biomolecular chemistry 20081121

Title: The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes.

Journal: Anesthesia and analgesia 20081101

Title: The effects of aromatic anesthetics on dorsal horn neuronal responses to noxious stimulation.

Journal: Anesthesia and analgesia 20080601

Title: Scope and limitations of the SCS-MP2 method for stacking and hydrogen bonding interactions.

Journal: Physical chemistry chemical physics : PCCP 20080521

Title: Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).

Journal: Journal of medicinal chemistry 20071115

Title: Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids.

Journal: Organic letters 20070510

Title: Lidocaine, MK-801, and MAC.

Journal: Anesthesia and analgesia 20070501

Title: Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.

Journal: Anesthesia and analgesia 20070401

Title: Photoinduced electron transfer in a hexaphenylbenzene-based self-assembled porphyrin-fullerene triad.

Journal: Photochemistry and photobiology 20070101

Title: Synthesis development of a naphthyridinone p38 kinase inhibitor.

Journal: Current opinion in drug discovery & development 20061101

Title: Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.

Journal: Anesthesia and analgesia 20060501

Title: Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?

Journal: Anesthesia and analgesia 20060501

Title: Novel synthesis of desymmetrized resorcinol derivatives: aryl fluoride displacement on deactivated substrates.

Journal: The Journal of organic chemistry 20060303

Title: 9-(2,6-Difluorophenoxycarbonyl)-10-methylacridinium trifluoromethanesulfonate and its precursor 2,6-difluorophenyl acridine-9-carboxylate: C-H...O, C-F...pi, S-O...pi and pi-pi stacking interactions.

Journal: Acta crystallographica. Section C, Crystal structure communications 20051201

Title: (+/-)-Methyl and (+/-)-ethyl 4-(2,3-difluorophenyl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20051201

Title: Naked (C5Me5)2M cations (M = Sc, Ti, and V) and their fluoroarene complexes.

Journal: Journal of the American Chemical Society 20051019

Title: Ion pairing in tetraphenylporphyrin oxidation: a semiquantitative study.

Journal: Dalton transactions (Cambridge, England : 2003) 20051007

Title: [New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301

Title: Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase.

Journal: Biochemistry 20041214

Title: Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: Examination of 19F-NMR as a tool for investigation of drug-cyclodextrin complexes.

Journal: Drug development and industrial pharmacy 20030101

Title: Structure-activity relationships of 6-nitroquinazolines: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.

Journal: Chemical & pharmaceutical bulletin 20020801

Title: Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods.

Journal: Chirality 20010601

Title: Methoxy[meso-5,10,15,20-tetrakis-(2,6-difluorophenyl)porphyrinato]-iron(III), [Fe(TDFPP)(OCH3)].

Journal: Acta crystallographica. Section C, Crystal structure communications 20010501

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Tags:367-11-3 Molecular Formula|367-11-3 MDL|367-11-3 SMILES|367-11-3 1,2-Difluorobenzene |Fluorinated_Building_Blocks